The significance of adenosine cyclic 3′,5′‐monophosphate for the contraction of smooth muscle

Bartelstone, Herbert J.; Nasmyth, P. A.; Telford, Jane

doi:10.1113/jphysiol.1967.sp008131

Cited by 42 publications

(24 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Von Euler and Lishajko (196B) found that the ATP-dependent noradrenaline uptake into storage granules isolated from rat brain could be blocked by both a-and s-adrenergic blocking agents. increase in cyclic-AMP levels associated with a-receptor activation (Bartelstone et ~., 1967;Jarrott, 1972) are in conflict with this pro-…”

Section: General Introductionmentioning

confidence: 99%

Transformation of Adrenergic Receptors in the Myocardium

1973

View full text Add to dashboard Cite

·ABSTRACTThe present series of experiments provided evidence that the generally accepted distinction between a-and s-adrenergic receptors is not immutable. In frog hearts and rat atria 3H-phenoxybenzamine (3H-POB ) blocked inotropic responses to catecholamines only at temperatures below l7 0 C and potentiated responses ab ove 23 0 C, and considerably more radioactivity was bound to the myocardium at lower temperatures. The converse was true for l4C-propranolol, and the potency of a-and s-adrenergic agonists was shawn to parallel the effectiveness of the blocking agents. Alkylation of a-adrenergic receptors by POB at l4 0 c prevented the appearance of s-adrenergic receptors when the temperature was subsequently raised ta 24 o C.Phentolamine prevented block by 3H-POB and considerably reduced its binding ta the myocardium at low but not at high temperatures. After exposure ta unlabelled POB in the presence of phentolamine at low temperature and thorough washing, exposure to 3H-POB produced a IIpositive label" of the adrenergic receptors, which was localized in a 20,000 9 (ll mitochondrial ll ) and in a IIsoluble protein" fraction. Pretreatment of rats with 6-hydroxydopamine, but not with reserpine, prevented the appearance of oe-adrenergic receptor charac.teristics in left atria at low temperatures; this indicated that adrenergic innervation, but probably not stores of neurotransmitter, is necessary to allow transformation of the receptors. It is suggested that a-and S-adrenergic receptors may be different allosteric conformations of the same molecule.

show abstract

Section: General Introductionmentioning

confidence: 99%

Transformation of Adrenergic Receptors in the Myocardium

1973

View full text Add to dashboard Cite

show abstract

“…The studies of Bartelstone & Nasmyth (1963), and of Bartelstone, Nasmyth & Telford (1967), indicated that vasoconstrictors increased the level of cyclic AMP although Robison & Sutherland (1970) claimed the converse to be the case, and Triner, Vulliemoz, Schwartz & Nahas (1970) and Volicier & Hynie (1971) showed that vasodilatation was associated with an accumulation of cyclic AMP.…”

Section: Introductionmentioning

confidence: 99%

The effects of some phosphodiesterase inhibitors on the conductance of the perfused vascular beds of the chloralosed cat

Hamilton

1972

British J Pharmacology

View full text Add to dashboard Cite

Summary1. The vasoactivity of a number of phosphodiesterase inhibitors in the autoperfused splanchnic region and hindquarters of the cat have been investigated. 2. Theophylline, dipyridamole and 4-(3,4-dimethoxybenzyl)-2-imidazolidinone (Ro 7-2956) and its analogues were more potent vasodilators in the splanchnic region than in the hindquarters, whereas papaverine was a potent vasodilator in both these vascular beds.3. The vasodilator response to the phosphodiesterase inhibitors in the splanchnic region and hindquarters was not susceptible to 8-adrenoceptor blockade.4. Infusion of dibutyryl cyclic AMP into the superior mesenteric artery increased vascular conductance of the splanchnic region. This effect was enhanced by Ro 20-1724 in doses below those in which this compound affected conductance. 5. These results are consistent with the hypothesis that accumulation of cyclic AMP in vascular smooth muscle mediates the vasodilator response to phosphodiesterase inhibitors.

show abstract

“…It is possible, therefore, that thyroxine potentiates the stimulant effects of (+)-amphetamine and caffeine indirectly by causing accumulation of cyclic AMP. Bartelstone, Nasmyth & Telford (1967) using smooth muscle have provided evidence that drugs which increase the tissue levels of cyclic AMP also increase responses to sympathomimetic amines, and that the reverse is also true.…”

Section: Discussionmentioning

confidence: 99%

The effect of thyroid hormones on the action of some centrally acting drugs

Coville

Telford

1970

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

Summary1. The effect of administration of thyroxine or thyroidectomy on the pharmacological action of (+)-amphetamine, caffeine, hexobarbitone and morphine was determined in rats or mice. 2. Locomotor activity induced by (+)-amphetamine or caffeine was increased by hyperthyroidism and decreased by hypothyroidism.3. The LD50s of (+)-amphetamine and caffeine in hyperthyroid rats were 1/30 and 2/5 that of control rats. With each drug, the LD50 regression lines in hyperthyroid and control rats were not parallel, suggesting that hyperthyroidism modifies the mechanism of the toxic effects. Hypothyroidism reduced toxicity to (+)-amphetamine. 4. Hexobarbitone sleeping time was prolonged in hyperthyroid male rats, but was shortened in hyperthyroid female rats. In control rats, sleeping time was approximately four times as long in females as it was in males. Ethinyloestradiol treatment and castration also prolonged sleeping time in male rats. No further prolongation was produced by combined administration of thyroxine and ethinyloestradiol, but thyroxine further prolonged the sleeping time of castrated rats indicating that its mode of action in producing these changes is not mediated via sex hormones. 5. In contrast to rats, a sex difference in the duration of action of hexobarbitone was not found in mice. Thyroxine prolonged sleeping time equally in each sex.

show abstract

The significance of adenosine cyclic 3′,5′‐monophosphate for the contraction of smooth muscle

Cited by 42 publications

References 12 publications

Transformation of Adrenergic Receptors in the Myocardium

Transformation of Adrenergic Receptors in the Myocardium

The effects of some phosphodiesterase inhibitors on the conductance of the perfused vascular beds of the chloralosed cat

The effect of thyroid hormones on the action of some centrally acting drugs

Contact Info

Product

Resources

About