The significance of ABC transporters in human placenta for the exposure of the fetus to xenobiotics

Vähäkangas, Kirsi; Veid, Jenni; Karttunen, Vesa; Partanen, Heidi; Sieppi, Elina; Kummu, Maria; Myllynen, Päivi; Loikkanen, Jarkko

doi:10.1016/b978-0-12-382032-7.10079-7

Cited by 8 publications

(7 citation statements)

References 217 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cigarette smoke contains more than 5300 constituents and according to IARC, for 70 of them there is sufficient evidence for carcinogenicity in laboratory animals or humans [5]. Placental barrier with transporter proteins, as well as xenobiotic metabolism of the mother, the unborn child and the placenta determine the exposure of the offspring to different chemicals [8, 102]. …”

Section: Discussionmentioning

confidence: 99%

“…Carcinogenic tobacco smoke constituents and metabolites, such as polycyclic hydrocarbons, N-nitroso compounds, their precursors, and nicotine, have been shown to cross the placenta [8, 9]. Already more than a decade ago higher concentrations of DNA adducts related to cigarette smoke carcinogens have been isolated from cord blood of smokers compared to non-smokers [1].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Smoking and the Risk of Cancer in Early Life – A Meta-Analysis

et al. 2016

View full text Add to dashboard Cite

BackgroundIn spite of the well-known harmful effects on the fetus, many women continue smoking during pregnancy. Smoking as an important source of toxic chemicals may contribute to the developmental origin of diseases.ObjectivesThe aim of this work was to pursue the possible association between maternal smoking and cancer in early life. Specifically, we wanted to identify the associated early life cancer types, and to quantify the associations.MethodsIn a systematic literature search 825 articles were identified in PubMed and Web of Science, and 55 more through the reference lists. Of these 62 fulfilled the criteria for inclusion in meta-analyses. Using Mantel-Haenszel or DerSimonian and Laird method, depending on heterogeneity of the studies, pooled estimates and 95% confidence intervals for eight cancer types were calculated.ResultsSmoking during pregnancy was associated with an increased risk for for brain and central nervous system tumors (OR = 1.09; 95% CI = 1.02–1.17). Although the risk for lymphoma was also associated (OR = 1.21; 95% CI = 1.05–1.34), it did not hold up in subgroup analyses. Leukemia was not found to be associated with maternal smoking. Five other cancer types (bone, soft tissue, renal, hepatic, and germ cell cancer) were also examined, but the number of studies was too limited to exclude the possibility of maternal smoking as a risk factor for cancer in offspring.ConclusionsAccording to our meta-analyses, maternal smoking is associated with nervous system cancers, but not with leukemia in early life. Confirming or rejecting associations of maternal smoking with lymphoma and the five other cancer types requires further studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal Smoking and the Risk of Cancer in Early Life – A Meta-Analysis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Foetal exposure to toxic compounds through maternal circulation has been proved in many studies by detecting the same carcinogens in umbilical cord blood as in maternal blood [for reviews, see e.g. 5,15]. Evidence from animals and human beings suggests that foetus is vulnerable to toxic effects of food and environmental carcinogens including post‐natal cancer [1–4].…”

Section: Discussionmentioning

confidence: 99%

“…There are only a few methods to study foetal exposure or transfer of toxic compounds through the human placenta. In addition to in vitro methods [17] and ex vivo human placental perfusion model [15,16], direct measurements of xenobiotics or theirs adducts in amniotic fluid, meconium or umbilical cord blood provide in vivo information about foetal exposure [61,62]. However, these direct measurements do not tell about placental transfer kinetics.…”

Section: Human Placental Perfusion In the Studies Of Foetal Exposure mentioning

confidence: 99%