The Side of Pneumonectomy Influences Long-Term Survival in Stage I and II Non-Small Cell Lung Cancer

Simón, Carlos; Moreno, Nicolás; Peñalver, Rafael; Gonzalez, Guillermo; Álvarez-Fernández, Emilio; González-Aragoneses, Federico

doi:10.1016/j.athoracsur.2007.04.075

Cited by 21 publications

(25 citation statements)

References 22 publications

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“…This is particularly evident in patients with T1N0 stage in whom the 5-year survival after pneumonectomy is only 41% versus 68% after lesser resections. This finding was confirmed by other authors who found an additional risk of right sided pneumonectomy in early stage lung cancer with a 5-year survival after right pneumonectomy of only 33% (75). Pneumonectomy is also a consistent factor associated with a poorer quality of life after surgery (76)(77)(78) and greater functional loss (32).…”

Section: Pneumonectomysupporting

confidence: 77%

Preoperative functional workup for patients with advanced lung cancer

Brunelli

2016

J. Thorac. Dis.

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Locally advanced lung cancer remains a surgical indication in selected patients. This condition often demands larger resections. As a consequence preoperative functional workup is of paramount importance to stratify the risk and choose the most appropriate treatment. We reviewed the current evidence on functional evaluation with a special focus on specific aspects related to locally advanced lung cancer stages (i.e., risk after neoadjuvant treatment, pneumonectomy). Evidence is discussed to provide information that could assist clinicians in their preoperative workup of these challenging patients.

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Section: Pneumonectomysupporting

confidence: 77%

Preoperative functional workup for patients with advanced lung cancer

Brunelli

2016

J. Thorac. Dis.

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“…The mechanism of this phenomenon is unclear, but this finding indicates that patients with tumors on the right side should undergo testing for EGFR mutation. Third, previous studies have shown that the risk of early perioperative death and survival differs between patients who undergo right or left side pneumonectomy . Despite these factors, large sample data with scientific and rigorous statistical methods are lacking.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that the risk of early perioperative death and complications is high after right side pneumonectomy, but long‐term survival did not differ between right and left side pneumonectomy . Another study showed that median survival was better after pneumonectomy for stage II left tumors . However, to date, no study has been designed to investigate whether primary tumor location alone is a prognostic factor of the influence of pneumonectomy or other surgical procedures.…”

Section: Discussionmentioning

confidence: 99%

“…Third, previous studies have shown that the risk of early perioperative death and survival differs between patients who undergo right or left side pneumonectomy. 5,9 Despite these factors, large sample data with scientific and rigorous statistical methods are lacking.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have mainly focused on the impact of pneumonectomy on cancer mortality between right and left side NSCLC, but less information on patients receiving other types of surgical procedures is available. 9,10 Because surgery is the most important treatment method for stage I-IIIA NSCLC, illustrating the survival difference in such patients is of great value. The choice of surgical procedure is closely related to primary tumor site, which could greatly influence survival.…”

Section: Introductionmentioning

confidence: 99%

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Survival comparison of right and left side non‐small cell lung cancer in stage I–IIIA patients: A Surveillance Epidemiology and End Results (SEER) analysis

Jia

Zheng

et al. 2019

Thoracic Cancer

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Background Primary tumors located in the right and left side have distinctive prognoses, but the details have not been fully identified in non‐small cell lung cancer (NSCLC). This study investigated the impact of primary tumor side on long‐term survival in NSCLC patients. Methods Data of 90 407 patients from the Surveillance, Epidemiology, and End Results (SEER) Program were analyzed. To avoid bias between groups, we used innovative propensity score matching (PSM) analysis. Results There was no significant distinction in overall survival (OS) between right ( n = 53 496) and left ( n = 36 911) side tumors (hazard ratio [HR] 0.993, 95% confidence interval [CI] 0.9756–1.011; P = 0.432). Left side was associated with superior five‐year cancer‐specific survival (CSS) compared to right side NSCLC (HR 0.977, 95% CI 0.9574–0.9969; P = 0.024). No significant difference was observed in OS ( P = 0.689) or CSS ( P = 0.288) after PSM analysis. In the 51 319 patients who underwent surgery, left side ( n = 21 245) was associated with poor OS compared to right side ( n = 30 074) NSCLC (HR 1.039, 95% CI 1.011–1.067; P = 0.006), while CSS was similar (HR 1.031, 95% CI 0.997–1.065; P = 0.069). In patients who underwent surgery, there was also no significant difference in OS ( P = 0.986) or CSS ( P = 0.979) after PSM analysis. Conclusion The prognosis between right and left side NSCLC in stage I–IIIA was similar regardless of whether patients underwent surgery. Primary tumor side cannot be considered a prognostic factor when choosing appropriate treatment.

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