The sick lobe hypothesis, field cancerisation and the new era of precision breast surgery

Tan, Mélissa; Tot, Tibor

doi:10.21037/gs.2018.09.08

Cited by 14 publications

(8 citation statements)

References 45 publications

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“…The average number of ostia in which two or more ducts merged was 3.6. Except for the common ostium just beneath the tip of the nipple, there was no anastomosis between the lactiferous ducts within the nipple, which is consistent with the sick-lobe theory proposed by Tan and Tot [104]. Without XDFI, the 3D study of such large samples would not be feasible.…”

Section: Microanatomy Of the Nipplesupporting

confidence: 72%

X-ray dark-field phase-contrast imaging: Origins of the concept to practical implementation and applications

et al. 2020

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The basic idea of X-ray dark-field imaging (XDFI), first presented in 2000, was based on the concepts used in an X-ray interferometer. In this article, we review 20 years of developments in our theoretical understanding, scientific instrumentation, and experimental demonstration of XDFI and its applications to medical imaging. We first describe the concepts underlying XDFI that are responsible for imparting phase contrast information in projection X-ray images. We then review the algorithms that can convert these projection phase images into three-dimensional tomographic slices. Various implementations of computed tomography reconstructions algorithms for XDFI data are discussed. The next four sections describe and illustrate potential applications of XDFI in pathology, musculoskeletal imaging, oncologic imaging, and neuroimaging. The sample applications that are presented illustrate potential use scenarios for XDFI in histopathology and other clinical applications. Finally, the last section presents future perspectives and potential technical developments that can make XDFI an even more powerful tool.

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Section: Microanatomy Of the Nipplesupporting

confidence: 72%

X-ray dark-field phase-contrast imaging: Origins of the concept to practical implementation and applications

et al. 2020

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“…Hence, a reductionist, or minimalist approach to fulfil oncologic requirements may provide optimal results (32,33). Such an approach would require an integration of appropriate preoperative imaging, careful surgical planning and detailed pathologic examination (34,35). This is consistent with the argument by Marescaux et al that iatrogenic impact should be reduced in surgical innovation for patient safety and quality of life (36).…”

Section: The Art Of Bctmentioning

confidence: 66%

Future perspectives for breast conservation treatment: science & art

Tan¹,

Silva

2018

Gland Surg

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“…Due to the retrospective design of the present study, this method could not be applied to all our patients. A prospective study using large-format histopathology sections would provide a better understanding of the subgross morphology and lobar anatomy of the breast and improved radiology–histopathology coordination (2–4,9,16,32,36,37). The present study is also intended to inspire such an approach.…”

Section: Discussionmentioning

confidence: 99%

Mass and non-mass breast MRI patterns: a radiologic approach to sick lobe theory

et al. 2020

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Background According to sick lobe theory, one or more lobes of the breast are more prone to the development of carcinoma. However, the implications of this theory in breast magnetic resonance imaging (MRI) are unknown. Purpose To evaluate the MRI appearance of mass type (multifocal and multicentric diseases) and non-mass type (non-mass enhancements) sick lobe patterns, together with the histopathology results. Material and Methods MRI reports of 2015 patients in two tertiary breast imaging centers between June 2012 and June 2018 were retrospectively reviewed for multifocal–multicentric diseases and segmental, linear, and regional enhancements. A total of 113 patients were included. The specimens obtained by thick needle, vacuum, excisional biopsy/lumpectomy or mastectomy after breast MRI scans were pathologically assessed. The pathologic results were categorized as invasive carcinoma, precursor, and benign proliferative lesions according to the 2012 World Health Organization Classification of Tumors. Results The percentage of underlying benign and precursor invasive lesions was significantly different in patients with mass and non-mass MRI patterns. While the pathology results of mass type patterns were premalignant and malignant in all cases, nearly half of the underlying histologies were benign proliferative subtypes in patients with non-mass type patterns. Conclusion In this study, the mass and non-mass patterns derived from sick lobe theory were related to different risks of malignancy in the pathological examinations.

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The sick lobe hypothesis, field cancerisation and the new era of precision breast surgery

Cited by 14 publications

References 45 publications

X-ray dark-field phase-contrast imaging: Origins of the concept to practical implementation and applications

X-ray dark-field phase-contrast imaging: Origins of the concept to practical implementation and applications

Future perspectives for breast conservation treatment: science & art

Mass and non-mass breast MRI patterns: a radiologic approach to sick lobe theory

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