The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life

Emous, Marloes; Wolffenbuttel, Bruce H. R.; Totté, E.; Beek, André P van

doi:10.1016/j.soard.2017.04.028

Cited by 57 publications

(64 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A gastrointestinal complication of malabsorptive surgical procedures is dumping syndrome which arises from rapid gastric emptying leading to gastrointestinal and vasomotor symptoms. 72 These can be classified into early or late, with early dumping being the most common and which occurs 30 minutes following a meal. This is associated with abdominal symptoms include pain, bloating, diarrhoea and borborygmi.…”

Section: Dumping Syndromementioning

confidence: 99%

Current treatments for obesity

et al. 2019

View full text Add to dashboard Cite

Obesity is a major health and economic crisis facing the modern world. It is associated with excess mortality and morbidity and is directly linked to common conditions such as type 2 diabetes mellitus, coronary heart disease and sleep apnoea. The management of obesity and its associated complications has evolved in recent years, with a shift towards more definitive strategies such as bariatric surgery. This review encompasses the dietary, pharmacological and surgical strategies currently available for the management of obesity.

show abstract

Section: Dumping Syndromementioning

confidence: 99%

Current treatments for obesity

et al. 2019

View full text Add to dashboard Cite

show abstract

“…As our second potential outcome, we chose a reduced rate of hypoglycemic episodes. Both reliably measurable by validated instruments such as questionnaires (8) or continuous glucose monitoring systems respectively (24).…”

Section: Resultsmentioning

confidence: 99%

“…One of them is postprandial hypoglycemia (PBH), previously referred to as late-dumping, affecting in standardized test settings about 50% of patients with a gastric bypass(4-6) although it is frequently undiagnosed (7). This may lead to a reduced quality of life (8), secondary weight gain (9,10) and may even be associated with an increased mortality (11)(12)(13). Serious hypoglycemia requiring assistance of third parties and/or hospitalization for hypoglycemia affects around 1% (8,14).…”

Section: Introductionmentioning

confidence: 99%

“…This may lead to a reduced quality of life (8), secondary weight gain (9,10) and may even be associated with an increased mortality (11)(12)(13). Serious hypoglycemia requiring assistance of third parties and/or hospitalization for hypoglycemia affects around 1% (8,14). Although some patients are able to effectively control hypoglycemic episodes with dietary modi cation, there is no established treatment for severely affected patients with frequent postprandial hypoglycemia (5).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Patient Involvement to Inform the Design of a Clinical Trial in Postbariatric Hypoglycemia

Hepprich¹,

Donath

Hemkens

2020

Preprint

View full text Add to dashboard Cite

Background: Bariatric surgery may lead to symptomatic postprandial hypoglycemia as a major side effect without established therapy so far. We aimed to develop an evidence-based study design of a clinical trial that tests treatment options and can provide useful patient-relevant evidence.Methods: We searched systematically for guidance of core outcome sets to determine the most relevant types of outcomes and duration of such a trial. Our search comprised literature databases, a database of core outcome sets and self-help organizations. We then developed a simple online questionnaire based on interviews with German-speaking patients with postprandial hypoglycemia after bariatric surgery. We recruited participants by reaching out to all German speaking endocrinologists in Switzerland and large Swiss bariatric centers. We asked for preferences regarding outcome types and acceptable duration of being included in a corresponding clinical trial.Results: The systematic search did not identify evidence-based guidance for informing our study design. Experience of clinical and research routine as well as patient interviews helped in identifying potential outcomes and the design of an online questionnaire. Therein, a total of 29 persons started the questionnaire and 22 answered questions related to the primary outcome. Of these, 17 (77.3%) deemed quality of life more relevant as primary outcome than the rate of hypoglycemic episodes. A trial length of four weeks or longer was regarded as acceptable for 19 of 21 respondents to this question (91.4 %) and of six months or longer for 12 respondents (56 %). Conclusions: In situations with no other guidance, a simple questionnaire may help to inform trial design decisions. This study identifies a patient preference for “quality of life” as a primary outcome and supports the evidence-based conception of a patient-centered clinical trial in postbariatric hypoglycemia.

show abstract

“…Para melhor clarificar a génese da sintomatologia pós-prandial em doentes submetidos a cirurgia bariátria, impõe-se a necessidade de distinguir dois quadros distintos: 1) síndrome de dumping precoce e 2) hipoglicemia pós-bypass gástrico, também referido historicamente como síndrome de dumping tardio. 16 O primeiro é causado pela chegada de alimentos não digeridos ao intestino delgado com consequente transferência de fluídos do compartimento intravascular para o lúmen do intestino. Ocorre contração do volume intravascular e elevação do hematócrito com aumento da frequência cardíaca.…”

Section: Apresentação Clínicaunclassified

Sociedade Portuguesa para o Estudo da Obesidade Recommendations on the Management and Treatment of Hypoglycaemia After Bariatric Surgery

Esteves¹,

Rocha²,

Alves³

et al. 2019

Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo

View full text Add to dashboard Cite

A cirurgia bariátrica constitui uma estratégia efi caz de tratamento da obesidade. A hipoglicemia após cirurgia bariátrica é uma complicação progressivamente mais reconhecida nos últimos anos, em particular após a cirurgia de bypass gástrico. As potenciais implicações de saúde para os doentes submetidos a cirurgia bariátrica, e em particular o atingimento na qualidade de vida que lhe está associado, exigem a adopção de estratégias efi cazes para o diagnóstico e tratamento deste problema. Este documento visa reunir e divulgar o conhecimento atual relativamente à abordagem e tratamento da hipoglicemia após cirurgia bariátrica.

show abstract

The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life

Cited by 57 publications

References 32 publications

Current treatments for obesity

Current treatments for obesity

Patient Involvement to Inform the Design of a Clinical Trial in Postbariatric Hypoglycemia

Sociedade Portuguesa para o Estudo da Obesidade Recommendations on the Management and Treatment of Hypoglycaemia After Bariatric Surgery

Contact Info

Product

Resources

About