The short term satiety peptide cholecystokinin reduces meal size and prolongs intermeal interval

CCK-8 and CCK-58 differ in their effects on nocturnal solid meal pattern in undisturbed rats

“…In addition, the increased latency to start the first meal further supports that meal size and IMI result from different mechanisms. Our results with exogenous CCK-58 are in keeping with recent findings where camostat gavage (which releases endogenous CCK) reduced food intake by decreasing meal size and prolonging IMI, whereas exogenous CCK-8 reduced food intake by reducing meal size only (33). Because the satiety ratio is calculated by IMI (min) divided by the first meal (g), an extended IMI and small meal size result in a high satiety ratio.…”

“…Sayegh and coworkers (33) have shown that effects of endogenous CCK on meal size and IMI are partly regulated by the CCK 1 receptor (55). Because these findings suggest a differential action in vivo, even though both CCK-8 and CCK-58 bind to the same receptors with different affinity (45), it is important to address what accounts for these different actions.…”

“…Most studies on CCK's regulation of food intake have been done with CCK-8 (2,22,30), after long fasting periods or during the light phase using liquid meals (32,33,36,37). So far, only one report compared the feeding microstructure in response to CCK-8 and CCK-58, using an automated system measuring the intake of powdered food (20).…”

Determinants of body weight regulation in humans

“…These results suggest that high fat feeding leads to impairments in lipid-induced CCK satiation signaling in obese-prone rats, potentially contributing to hyperphagia and weight gain. Moreover, to evaluate CCK function on meal size and intermeal interval, CCK was injected in experimental rodents during every spontaneous meal by intraperitoneal catheters with extended of both (36). However, the absence of CCK signaling seems has no effect on long term energy homeostasis.…”

Overeating makes the gut grow fonder; new insights in gastrointestinal satiety signaling in obesity

“…Traditionally, CCK was considered to reduce food intake by limiting the meal size on a meal-by-meal basis, but longer forms of CCK prolong the between-meal interval, which makes the CCK receptor an interesting treatment target for obesity [4,5].…”