The short term effect of peripherally administered brain-gut peptides on gastric acid secretion in rats

Zanelli, Joan M.; Stracca-Gasser, M.; Gaines-Das, R.; Guidobono, F.

doi:10.1007/bf01990961

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…It is likely that such functional differentiation is also present in the gastric myenteric plexus, because studies on the innervation pattern of the musculature and the mucosa of the guinea-pig stomach have revealed differences in the distribution and density of ChAT-, NPY-, SP-and NOS-positive nerve fibres (Schultzberg et al 1980;Furness et al 1983Furness et al , 1994Keast et al 1985;Mawe et al 1989). In addition, transmitters used by the ENS, such as acetylcholine, NO, SP or NPY, modulate gastric motility (Milenov and Golenhofen 1983;Jin et al 1993;Meulemans et al 1993;, mucosal blood flow (Saperas et al 1995;Chen et al 1993;Holzer 1995;Tepperman and Whittle 1991), acid secretion (Hersey and Sachs 1995;Tsai and Cheng 1990;Zanelli et al 1992;Penner et al 1993), pepsinogen secretion (Hirschowitz and Sachs 1969;Vigna et al 1989;Kitsukawa et al 1996;Raufman and Singh 1991), bicarbonate secretion (Fändriks 1986;Bilski and Konturek 1994;Takeuchi et al 1993) and mucus secretion (Brown et al 1992;Price et al 1994).…”

Section: Introductionmentioning

confidence: 98%

Different subpopulations of cholinergic and nitrergic myenteric neurones project to mucosa and circular muscle of the guinea-pig gastric fundus

Pfannkuche

Reiche

Sann

et al. 1998

Cell and Tissue Research

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Since the stomach lacks a well-developed ganglionated submucous plexus, the somata of enteric neurones innervating the muscle or the mucosa have to be localised within the myenteric plexus. The aim of this study was to determine the projection pathways and the neurochemical coding of myenteric neurones innervating these different targets in the gastric fundus. Myenteric cell bodies projecting to the mucosa or the circular muscle were retrogradely labelled by mucosa or muscle application of the fluorescent tracer DiI and subsequently characterised by their immunoreactivity for choline acetyltransferase (ChAT), nitric oxide synthase (NOS), substance P (SP) and/or neuropeptide Y (NPY). On average 14391 and 8949 myenteric neurones were labelled from the mucosa and the circular muscle, respectively. DiI-labelled neurones were either ChAT-or NOS-positive. DiI-labelled ChAT-positive neurones were mainly ascending and outnumbered NOS-positive neurones, which were mainly descending (79.36.2% vs 20.76.2% for mucosa neurones; 69.311.1% vs 30.711.1% for muscle neurones). Three ChAT-positive subpopulations (ChAT/±, ChAT/SP, ChAT/NPY) and two NOS-positive subpopulations (NOS/±, NOS/NPY) were found. ChAT/SP neurones projected mainly to the circular muscle (36.111.9% of the cholinergic muscle neurones; mucosa projection: 8.02.1%), whereas ChAT/NPY neurones projected mainly to the mucosa (38.19.2% of the cholinergic mucosa neurones; muscle projection: 5.72.4%). NOS/± cells projected predominantly to the muscle. This study demonstrates polarised pathways in the myenteric plexus consisting of ascending ChAT and descending NOS cells that innervate the circular muscle and the mucosa of the gastric fundus. The ChAT/SP neurones might function as circular muscle motor neurones, whereas ChAT/NPY neurones might represent secretomotor neurones.

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Section: Introductionmentioning

confidence: 98%

Different subpopulations of cholinergic and nitrergic myenteric neurones project to mucosa and circular muscle of the guinea-pig gastric fundus

Pfannkuche

Reiche

Sann

et al. 1998

Cell and Tissue Research

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“…The involvement of tachykinins in regulation of acid secretion has primarily been studied in rats. Intravenous infusion of SP had no effect on basal acid secretion in rats in vivo [73,74], but inhibited the stimulatory effect of electrical stimulation of the vagus nerves [74]. In an isolated rat gastric fundus preparation SP also did not affect basal acid secretion, but augmented the stimulatory effect of histamine [75].…”

Section: Review Articlementioning

confidence: 99%

Tachykinins in regulation of gastric motility and secretion

Schmidt

Holst

2000

CMLS, Cell. Mol. Life Sci.

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The tachykinins constitute a family of neu-receptors are generally present on the musculature, NK-1 receptors on both neurons and muscles, and NK-3 ropeptides with a common C-terminal amino acid sereceptors on neurons only. Tachykinins stimulate motilquence. The best known tachykinin is substance P. Tachykinins are found in the nerve plexuses and nerve ity in all parts of the stomach, but tachykinins also fibers in the stomach of all species examined. The circu-appear to inhibit motility in certain situations. Also, motility initiated centrally, mediated through the vagus lar muscle layer is densely innervated, whereas the lonnerves, is influenced by tachykinins. The precise role of gitudinal layer and the mucosa are less intensively tachykinin in the various motor programs in the stominnervated. Tachykinins are also found in a significant number of afferent neurons with cell bodies in the ach is not clear. Gastric acid secretion is influenced by dorsal root ganglia. Release of tachykinin can be tachykinins in several species. Tachykinins do not seem to act as neurotransmitters directly on parietal cells, but demonstrated in response to both electrical stimulation may have a modulatory function. The importance of of the vagus nerves and application of capsaicin. In the stomach all three known tachykinin receptors seem to tachykinins for the regulation of pepsinogen and horbe present. Although species variations exist, NK-2 mone secretion from the stomach remains unclear.

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“…Different effects of tachykinins have been found in different experimental models. Infusion of substance P (SP) had no effect on basal or bethanechol stimulated acid secretion in rats in vivo (Yokotani & Fujiwara 1985, Zanelli et al 1992, but inhibited vagally induced acid secretion (Yokotani & Fujiwara 1985). However, SP failed to in¯uence basal as well as acetylcholine stimulated acid secretion in dispersed rat parietal cells (Schepp et al 1990).…”

mentioning

confidence: 99%

Tachykinins stimulate acid and pepsinogen secretion in the isolated porcine stomach

Schmidt¹,

Rasmussen²,

Holst³

1999

Acta Physiologica Scandinavica

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To elucidate the underlying mechanism behind the thermogenic effect of adrenaline in human skeletal muscle, nine healthy subjects were studied during intravenous infusion of adrenaline. Restriction of blood flow to one forearm was obtained by external compression of the brachial artery, to separate a direct metabolic effect of adrenaline from an effect dependent on increased blood flow. The other arm served as the control arm. In the control arm, the forearm blood flow increased 4.7-fold (from 2.0 +/- 0.3 to 9.3 +/- 1.5 mL 100 g(-1) min(-1), P < 0.001) during the adrenaline infusion. Adrenaline significantly increased forearm oxygen consumption (from 4.7 +/- 2.1 to 7.0 +/- 3.6 micromol 100 g(-1) min(-1), P < 0.025). In the arm with restricted blood flow, the forearm blood flow increased 2.9-fold (from 1.6 +/- 0.3 to 4.6 +/- 0.8 mL 100 g(-1) min(-1), P < 0.002) but the forearm oxygen consumption did not increase (baseline period: 5.6 +/- 2.3 micromol 100 g(-1) min(-1), adrenaline period: 6.1 +/- 2.1 micromol 100 g(-1) min(-1), P = 0.54). The experimental design and the difficulties in interpretation of the result are discussed. The results give evidence for the hypothesis that the vascular system plays a key role in the thermogenic effect of adrenaline in skeletal muscle in vivo.

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The short term effect of peripherally administered brain-gut peptides on gastric acid secretion in rats

Cited by 8 publications

References 17 publications

Different subpopulations of cholinergic and nitrergic myenteric neurones project to mucosa and circular muscle of the guinea-pig gastric fundus

Different subpopulations of cholinergic and nitrergic myenteric neurones project to mucosa and circular muscle of the guinea-pig gastric fundus

Tachykinins in regulation of gastric motility and secretion

Tachykinins stimulate acid and pepsinogen secretion in the isolated porcine stomach

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