The short-term association between asthma hospitalisations, ambient temperature, other meteorological factors and air pollutants in Hong Kong: a time-series study

Lam, Holly Ching-yu; Li, Albert Martin; Chan, Emily Ying Yang; Goggins, William B.

doi:10.1136/thoraxjnl-2015-208054

Cited by 142 publications

(168 citation statements)

References 47 publications

Supporting

Mentioning

130

Contrasting

Unclassified

Order By: Relevance

“…Numerous time-series and case-crossover studies have reported that short-term exposure to both cold and hot temperatures were associated with increased risks of respiratory mortality10 and hospital admissions 11. Most of those studies focused on the adverse health effects of short-term mean temperature.…”

Section: Introductionmentioning

confidence: 99%

Seasonal temperature variability and emergency hospital admissions for respiratory diseases: a population-based cohort study

Sun

Laden

Hart

et al. 2018

Thorax

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Seasonal temperature variability and emergency hospital admissions for respiratory diseases: a population-based cohort study

Sun

Laden

Hart

et al. 2018

Thorax

View full text Add to dashboard Cite

show abstract

“…Asthmatics are at especially high risk for ozone-induced respiratory complications due to their heightened inflammatory and bronchoconstrictive responses (Peden et al 1997). Consequently, asthma-related emergency department visits and hospitalizations increase significantly 1-3 days after high ozone days (Mar and Koenig 2009;Gleason et al 2014;Sheffield et al 2015;Lam et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Ozone-induced eosinophil recruitment to airways is altered by antigen sensitization and tumor necrosis factor-αblockade

et al. 2017

View full text Add to dashboard Cite

Ozone is an atmospheric pollutant that causes lung inflammation and airway hyperresponsiveness. Ozone's effects occur in two distinct phases that are mediated by different populations of eosinophils. In the acute phase 1 day after exposure, mature airway‐resident eosinophils alter parasympathetic nerve function that results in airway hyperresponsiveness. At this time point, the severity of hyperresponsiveness correlates with the number of eosinophils in close proximity to airway nerves, but not with eosinophils in bronchoalveolar lavage. Three days later, newly divided eosinophils are recruited to airways by a tumor necrosis factor‐α‐dependent mechanism. These new eosinophils paradoxically attenuate ozone‐induced airway hyperresponsiveness. Ozone's effects on airway tissue eosinophils and nerve‐associated eosinophils 3 days after exposure are unknown. Thus, we tested ozone's effects on eosinophils in airway subepithelium and around airway nerves 1 and 3 days after ozone in nonsensitized and ovalbumin‐sensitized guinea pigs with or without the tumor necrosis factor‐α antagonist, etanercept, and compared changes in eosinophils with ozone‐induced airway hyperresponsiveness. More eosinophils were present in small, noncartilaginous airways and along small airway nerves compared to large cartilaginous airways in all treatment groups. The number of airway and nerve‐associated eosinophils were unaffected 1 day after ozone exposure, whereas significantly fewer airway eosinophils were present 3 days later. Airway and nerve‐associated eosinophils were also decreased in small airways 3 days after ozone in sensitized animals. These changes were blocked by etanercept. Airway eosinophils, but not nerve‐associated or bronchoalveolar lavage eosinophils correlated with airway hyperresponsiveness 3 days after ozone. Our findings indicate ozone causes persistent alterations in airway eosinophils and reinforce the importance of characterizing eosinophils’ effects within distinct airway compartments.

show abstract

“…The 2006 California heat wave was linked with increased risk of admission for acute renal failure, electrolyte imbalance, and nephritis (Knowlton et al 2009). Time series studies of heat and hospitalizations without focus on a particular heat event have found associations between heat and hospitalization for various respiratory, cardiovascular and renal conditions (Isaksen et al 2015; Lam et al 2016; Li et al 2015; Soneja et al 2016). A study of heat, heat waves, and hospitalizations among the elderly in 114 cities across the U.S. found associations between renal and respiratory hospitalizations and EH.…”

Section: Introductionmentioning

confidence: 99%

Vulnerability to extreme-heat-associated hospitalization in three counties in Michigan, USA, 2000–2009

et al. 2016

View full text Add to dashboard Cite

Background With climate change, extreme heat (EH) events are increasing, so it is important to understand who is vulnerable to heat-associated morbidity. We determined the association between EH and hospitalizations for all natural causes, cardiovascular, respiratory, and renal diseases, diabetes mellitus, and acute myocardial infarction in Michigan, USA at different intensities and durations. We assessed confounding by ozone and how individual characteristics and health insurance payer (a proxy for income) modified these associations. Methods We obtained Michigan Inpatient Database, National Climatic Data Center, and U.S. Environmental Protection Agency ozone data for May–September, 2000–2009 for three Michigan counties. We employed a case-crossover design and modeled EH as an indicator for temperature above the 95th, 97th or 99th percentile thresholds for 1, 2, 3 or 4 days. We examined effect modification by patient age, race, sex, and health insurance payer and pooled the county results. Results Among non-whites, the pooled odds ratio for hospitalization on EH (97th-percentile threshold) vs. non-EH days for renal diseases was 1.37 (95% CI = 1.13–1.66), which increased with increasing EH intensity, but was null among whites (OR = 1.00, 95% CI = 0.81, 1.25). We observed a null association between EH and cardiovascular hospitalization. EH (99th-percentile threshold) was associated with myocardial infarction hospitalizations. Confounding by ozone was minimal. Conclusions EH was associated with hospitalizations for renal disease among non-whites. This information on vulnerability to heat-associated morbidity helps characterize the public health burden of EH and target interventions including patient education.

show abstract

The short-term association between asthma hospitalisations, ambient temperature, other meteorological factors and air pollutants in Hong Kong: a time-series study

Abstract: People with asthma should avoid exposure to adverse conditions by limiting outdoor activities during periods of extreme temperatures, combinations of high humidity and high temperature, and low humidity and low temperature, and high ozone levels.

Cited by 142 publications

References 47 publications

Seasonal temperature variability and emergency hospital admissions for respiratory diseases: a population-based cohort study

Seasonal temperature variability and emergency hospital admissions for respiratory diseases: a population-based cohort study

Ozone-induced eosinophil recruitment to airways is altered by antigen sensitization and tumor necrosis factor-αblockade

Vulnerability to extreme-heat-associated hospitalization in three counties in Michigan, USA, 2000–2009

Contact Info

Product

Resources

About