The short-term and oncologic outcomes of laparoscopic versus open surgery for T4 colon cancer

Kim, Ik Yong; Kim, Bo Ra; Kim, Young Wan

doi:10.1007/s00464-015-4364-x

Cited by 54 publications

(72 citation statements)

References 27 publications

(60 reference statements)

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“…Colon cancer is characterized by various genetic and epigenetic changes (19), as well as molecular alterations. However, further studies are required to identify novel therapeutic targets to develop new treatment strategies (20). In the present study, the expression of miRNA-193b in human patients with CRC was determined to be high, as compared with healthy volunteers.…”

Section: Discussionmentioning

confidence: 99%

Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-β and regulation of the SMAD3 pathway

Zhao

et al. 2017

Oncology Letters

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MicroRNA-193b (miRNA-193b) is often differentially expressed and is an important regulator of gene expression in colon cancer. The aim of the present study was to determine whether miRNA-193b affects cell growth in colon cancer and to investigate the potential underlying mechanisms. Patients with colorectal cancer (CRC; n=20) and healthy volunteers (n=10) were enrolled from the Department of Gastrointestinal Surgery Center, First Affiliated Hospital of Sun Yat-Sen University (Guangzhou, China). Western blot analysis was used to evaluate the protein expression of SMAD3 and transforming growth factor-β (TGF-β) in the patient samples. It was determined that miRNA-193b expression was markedly elevated in the CRC tissue samples. Furthermore, silencing of miRNA-193bin SW620 CRC cells by specific inhibitors significantly reduced the cell proliferation and induced apoptosis. In addition, the downregulation of miRNA-193b significantly activated the protein expression of SMAD3 and TGF-β, and promoted caspase-3 activity in SW620 cells. The results of the present study suggested that the deregulation of miRNA-193b may affect cell growth in colon cancer via the TGF-β and SMAD3 signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-β and regulation of the SMAD3 pathway

Zhao

et al. 2017

Oncology Letters

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“…Some authors compared laparoscopic colorectal surgery in older patients with open surgery and substantially suggested that the minimally invasive procedures had a greater benefit on them. Few studies indicated that laparoscopy is a surgically safe and acceptable treatment approach for well-selected patients with colon cancer to ensure faster short-term recovery of the patients [9,16]. Until now, there have been no studies to determine whether minimally invasive surgery affects the ability to retrieve 12+ LNs in elective colon cancer surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies found that the mean number of LNs retrieval is greater in open CME [9]. When comparing laparoscopic colectomy and open colectomy, there has been no significant difference in number of LNs resected [9,16], and single-port versus multi-port laparoscopic techniques have also shown no significant difference in terms of number of harvested LNs [13,17].…”

Section: Introductionmentioning

confidence: 88%

“…Most studies achieved greater than 12 LNs using various procedures, such as laparoscopic complete mesocolic excision (CME), open CME, CME with complete vascular ligation, laparoscopic radical LN dissection including non-regional LNs, robotic surgery, intra-and extracorporeal laparoscopic surgery, single-and multi-port laparoscopic surgery, 2D versus 3D laparoscopic surgery and even a multidisciplinary approach [4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…Some studies when comparing laparoscopic-assisted and open mesocolic excision found that there is no difference in number of harvested LNs and oncologic clearance between the two groups [6,15]. Other studies found that the mean number of LNs retrieval is greater in open CME [9]. When comparing laparoscopic colectomy and open colectomy, there has been no significant difference in number of LNs resected [9,16], and single-port versus multi-port laparoscopic techniques have also shown no significant difference in terms of number of harvested LNs [13,17].…”

Section: Introductionmentioning

confidence: 99%

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Laparoscopic colectomies associated with decreased retrieval of 12 or more lymph nodes compared to open in elective colon cancer surgery

Puckett

Mitchell

Pham

2019

ecancer

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Background: Colorectal cancer is the third most commonly diagnosed cancer worldwide. Lymph node (LN) retrieval is a key factor for pathologic staging and prognosis of colorectal cancer. Increase in number of LNs removal suggests improvement in tumour clearance and decrease in metastatic spread. Studies have suggested that excising 12 or more LNs during colectomy in patients with colon cancer is associated with improved survival. To date, there have been no studies to determine whether minimally invasive surgery affects the ability to retrieve 12+ LNs in elective colon cancer surgery. Therefore, we elected to determine whether a difference exists on the ability to retrieve 12+ nodes in elective colon cancer colectomies performed open versus laparoscopic. Methods:The National Surgical Quality Improvement Program (NSQIP) Procedure Specific Colectomy database was analysed for the year 2014-2015. Inclusion criteria were colon cancer (ICD-9 Code 153.9), age greater than 18 years. Exclusion criteria were missing data. Data abstracted included patient demographics, type of operation performed and number of LNs retrieved. The patients were categorised based on their elective colon cancer colectomies such as laparoscopic or open. Binary logistic regression was used to identify confounding variables in the retrieval of 12+ LNs. Results:After accounting for missing cases, a total of 18,792 patients with a diagnosis of colon cancer were analysed. Twelve or more LNs were retrieved in 88% (16,538) of patients, Among them, 2,516 patients underwent laparoscopic colectomy and 5,284 patients underwent open colectomy. The difference was not statistically significant for the average number of LNs retrieved among both the groups. Open operative approach compared to the laparoscopic approach was associated with 15% greater odds of retrieval of >12 LNs (OR 1.148; 95% CI (1.035-1.272); p = 0.008). Conclusion:The majority of colectomies such as open or laparoscopic are able to retrieve 12 or more LNs. However, there are greater odds of retrieving more than 12 LNs with the open approach compared to the laparoscopic approach. By allowing for more LN retrieval, open colectomies suggest improvement in tumour clearance and decrease metastatic spread. Additional research is needed to further investigate the specific factors influencing the ability to retrieve an adequate number of LNs, such as viewing angles provided with an open approach versus laparoscopic approach.

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Identification of patient subgroups with unfavorable long‐term outcomes associated with laparoscopic surgery in a randomized controlled trial comparing open and laparoscopic surgery for colon cancer (Japan Clinical Oncology Group Study JCOG0404)

Saito¹,

Akagi

Katayama

et al. 2021

Annals of Gastroent Surgery

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The short-term and oncologic outcomes of laparoscopic versus open surgery for T4 colon cancer

Abstract: Our results indicate that laparoscopy is a surgically safe and oncologically acceptable approach and thus could be considered for well-selected patients with T4 colon cancer in order to allow faster short-term recovery.

Cited by 54 publications

References 27 publications

Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-β and regulation of the SMAD3 pathway

Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-β and regulation of the SMAD3 pathway

Laparoscopic colectomies associated with decreased retrieval of 12 or more lymph nodes compared to open in elective colon cancer surgery

Identification of patient subgroups with unfavorable long‐term outcomes associated with laparoscopic surgery in a randomized controlled trial comparing open and laparoscopic surgery for colon cancer (Japan Clinical Oncology Group Study JCOG0404)

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