The short-chain fatty acid propionate improved ventricular electrical remodeling in a rat model with myocardial infarction

Zhou, Mengting; Li, Diwen; Xie, Kexin; Xu, Lin; Kong, Bin; Wang, Xi; Tang, Yanhong; Liu, Yu; Huang, He

doi:10.1039/d1fo02040d

Cited by 21 publications

(14 citation statements)

References 50 publications

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“…Changes in cardiac gap junction proteins, including the decrease of Cx43 and spatial redistribution, are characterized by abnormal electrophysiological remodeling and are referred to as representing arrhythmogenic substrates (Severs et al, 2008). Zhou et al, (2021) found that propionic acid can improve the pathological remodeling of connexin in rats with myocardial infarction. propionic acid causes the nucleus tractus solitarius in the brain through the nodular ganglia to activate vagal afferent fibers in the gut and vagal efferent neurons that innervate the heart (Dalile et al, 2019).…”

Section: Atherosclerosismentioning

confidence: 99%

Gut microbiota and cardiac arrhythmia

Fan

Liu

Ren

et al. 2023

Front. Cell. Infect. Microbiol.

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One of the most prevalent cardiac diseases is cardiac arrhythmia, however the underlying causes are not entirely understood. There is a lot of proof that gut microbiota (GM) and its metabolites have a significant impact on cardiovascular health. In recent decades, intricate impacts of GM on cardiac arrythmia have been identified as prospective approaches for its prevention, development, treatment, and prognosis. In this review, we discuss about how GM and its metabolites might impact cardiac arrhythmia through a variety of mechanisms. We proposed to explore the relationship between the metabolites produced by GM dysbiosis including short-chain fatty acids(SCFA), Indoxyl sulfate(IS), trimethylamine N-oxide(TMAO), lipopolysaccharides(LPS), phenylacetylglutamine(PAGln), bile acids(BA), and the currently recognized mechanisms of cardiac arrhythmias including structural remodeling, electrophysiological remodeling, abnormal nervous system regulation and other disease associated with cardiac arrythmia, detailing the processes involving immune regulation, inflammation, and different types of programmed cell death etc., which presents a key aspect of the microbial-host cross-talk. In addition, how GM and its metabolites differ and change in atrial arrhythmias and ventricular arrhythmias populations compared with healthy people are also summarized. Then we introduced potential therapeutic strategies including probiotics and prebiotics, fecal microbiota transplantation (FMT) and immunomodulator etc. In conclusion, the GM has a significant impact on cardiac arrhythmia through a variety of mechanisms, offering a wide range of possible treatment options. The discovery of therapeutic interventions that reduce the risk of cardiac arrhythmia by altering GM and metabolites is a real challenge that lies ahead.

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Section: Atherosclerosismentioning

confidence: 99%

Gut microbiota and cardiac arrhythmia

Fan

Liu

Ren

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Recently, Luedde et al reported that the gut microbiome in HFpEF patients tended to have deficiencies in Ruminococcaceae and Blautia, which were SCFAs producers ( Beale et al, 2021 ). SCFAs were also beneficial to myocardial electrical remodeling for they could partly activate the parasympathetic nerves through the gut-brain axis ( Zhou et al, 2021 ). As for the underlying mechanism, Carley et al (2021) further revealed that SCFAs were efficient energy sources for HF patients because failing hearts preferred to oxidize SCFA over ketones.…”

Section: The Microbial Metabolites Associated With Heart Failurementioning

confidence: 99%

Microbial metabolites and heart failure: Friends or enemies?

Liu

Zhou

et al. 2022

Front. Microbiol.

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Heart failure (HF), a global health issue characterized by structural or functional cardiac dysfunction, which was found to be associated with the gut microbiome recently. Although multiple studies suggested that the gut microbiome may have an impact on the development of cardiovascular diseases, the underlying mechanism of the gut microbiome in HF remains unclear. The study of metabolites from gut microbiota influenced by dietary nutrition uptake suggested that gut microbiota may affect the process of HF. However, on the basis of the microbiota’s complicated roles and their interactions with metabolites, studies of microbial metabolites in HF had rarely been described so far. In this review, we focused on dietary nutrition-related factors that were involved in the development and progression of HF, such as trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and bile acids (BAs), to summarize their advances and several potential targets in HF. From a therapeutic standpoint, we discussed microbial metabolites as a potential strategy and their applications in HF as well.

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“…Ca2+ and GPR43-dependent mechanisms reduce NLRP3 inflammasome activation by acetate, thereby preventing inflammation-related arrhythmias [67]. It has also been shown that propionate prevents the development of myocardial infarction-induced ventricular arrhythmias (VA) and cardiac electrophysiological instability through parasympathetic activation based on the gut-brain axis [68].…”

Section: Arrhythmiasmentioning

confidence: 99%

Short-Chain Fatty Acids-A Healthy Bus between Gut Microbiota and Organs beyond the Gut

Cao¹,

Zeng²,

Li³

et al. 2022

ABB

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The impact of the gut microbiota is not limited to the intestine, but its interaction with the host produces active metabolites, which can be transported by the blood circulation to play important roles in various parts of the body. Among them, short-chain fatty acids (SCFAs), as important active products of gut bacteria, have been shown to exert anti-inflammatory and immunomodulatory effects and can play active roles as signaling molecules in the development of various intestinal and extraintestinal diseases, such as inflammatory bowel disease, colon cancer, multiple sclerosis, hypertension, allergic airway disease, obesity, diabetes, kidney disease, rheumatoid arthritis, etc. In this way, modulation of the intestinal microbiota and metabolism-active substances has gradually become a popular therapeutic method for many diseases of organs beyond the gut. To find new therapeutic targets for major human health problems, this article reviews the research on SCFAs in extraintestinal diseases.

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The short-chain fatty acid propionate improved ventricular electrical remodeling in a rat model with myocardial infarction

Abstract: Oral propionate activated vagal afferent nerve in the gut and facilitated solitary nucleus in the brain via nodose ganglia to activate vagal efferent nerve innervating the heart, so as to reduce ventricular arrhythmia after myocardial infarction.

Cited by 21 publications

References 50 publications

Gut microbiota and cardiac arrhythmia

Gut microbiota and cardiac arrhythmia

Microbial metabolites and heart failure: Friends or enemies?

Short-Chain Fatty Acids-A Healthy Bus between Gut Microbiota and Organs beyond the Gut

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