The short- and long-term outcomes of pancreaticoduodenectomy for distal cholangiocarcinoma

Skalický, Pavel; Urban, Ondřej; Ehrmann, Jiří; Svebisova, Hana; Klos, Dušan; Tesaříková, Jana; Neoral, C; Knapkova, K.; Loveček, Martin

doi:10.5507/bp.2021.043

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…Distal cholangiocarcinoma (dCCA) is a malignant neoplasm located in the last portion of the biliary tract, specifically from the junction of the cystic and hepatic ducts to the ampulla of Vater [ 1 ]. This neoplasm is an aggressive form of epithelial origin, representing approximately 30% of all cholangiocarcinomas [ 2 ]. The incidence of dCCA varies from 20% to 40% [ 3 ], with a higher prevalence reported in certain regions, such as Southeast Asia.…”

Section: Introductionmentioning

confidence: 99%

Comparative Outcomes of Minimally Invasive Versus Open Pancreatoduodenectomy in Distal Cholangiocarcinoma: A Systematic Review and Meta-Analysis

Domene,

Quiroz Flores,

Fulginiti

et al. 2024

Cureus

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Pancreatoduodenectomy, the primary surgical strategy for managing cholangiocarcinoma, is executed via two distinct methodologies, namely minimally invasive pancreatoduodenectomy (MIPD) and open pancreatoduodenectomy (OPD). The selection between these surgical options is critical, as it directly influences patient outcomes, encompassing both short-term recovery metrics and long-term survival rates. Despite the clinical significance of these procedures, there exists a notable void in the literature regarding a comprehensive comparison of MIPD and OPD, particularly in assessing their respective efficacies and complications. This lack of detailed comparative analysis has left a gap in evidence-based guidance for clinicians faced with the decision of choosing the most appropriate surgical approach for their patients. The absence of robust data comparing the two techniques underscores the necessity for a meta-analysis that rigorously examines and contrasts the outcomes associated with MIPD and OPD. By drawing upon a wide array of international studies, this research aims to shed light on the advantages and potential drawbacks of each method, thereby providing a more informed basis for surgical decision-making in the treatment of cholangiocarcinoma.

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Section: Introductionmentioning

confidence: 99%

Comparative Outcomes of Minimally Invasive Versus Open Pancreatoduodenectomy in Distal Cholangiocarcinoma: A Systematic Review and Meta-Analysis

Domene,

Quiroz Flores,

Fulginiti

et al. 2024

Cureus

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“…The risk of neoplastic development is potentiated and exacerbated by chronic inflammation, infections, and cholestasis [ 6 ]. Additionally, genetic disorders sustain tumor cell proliferation, migration, and survival, consequently being identified as risk factors [ 7 , 8 ]. Hence, there is a paramount need to explore novel therapeutic targets for CHOL patients.…”

Section: Introductionmentioning

confidence: 99%

DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma

Liu,

Wu,

Yan

et al. 2023

J Physiol Biochem

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DERL2 (derlin 2) is a critical component of the endoplasmic reticulum quality control pathway system whose mutations play an important role in carcinogenesis, including cholangiocarcinoma (CHOL). However, its role and its underlying mechanism have yet to be elucidated. Herein, we revealed that DERL2 was highly expressed in CHOL and considered as an independent prognostic indicator for inferior survival in CHOL. DERL2 ectopically expressed in CHOL cells promoted cell proliferation and colony formation rates, and depleting DERL2 in CHOL cells curbed tumor growth in vitro and in vivo. More interestingly, the knockout of DERL2 augmented the growth-inhibitory effect of gemcitabine chemotherapy on CHOL cells by inducing cell apoptosis. Mechanistically, we discovered that DERL2 interacted with BAG6 (BAG cochaperone 6), thereby extending its half-life and reinforcing the oncogenic role of BAG6 in CHOL progression.

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Preoperative nutritional support in patients undergoing pancreatic surgery affects PREPARE score accuracy

Skalicky,

Knapkova,

Tesarikova

et al. 2023

Front. Surg.

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BackgroundThis study aimed to validate the accuracy of the Preoperative Pancreatic Resection (PREPARE) risk score in pancreatic resection patients.Patients and methodsThis prospective study included 216 patients who underwent pancreatic resection between January 2015 and December 2018. All patients in our cohort with weight loss or lack of appetite received dietary advice and preoperative oral nutritional supplementation (600 kcal/day). Demographic, clinicopathological, operative, and postoperative data were collected prospectively. The PREPARE score and the predicted risk of major complications were computed for each patient. Differences in major postoperative complications were analyzed using a multivariate Cox proportional hazards regression model. The predicted and observed risks of major complications were tested using the C-statistic.ResultsThe study included 216 patients [117 men (54.2%)] with a median age of 65.0 (30.0–83.0) years. The majority of patients were classified as American Society of Anesthesiologists (ASA)’ Physical Status score II (N = 164/216; 75.9%) and as “low risk” PREPARE score (N = 185/216; 85.6%) before the surgery. Only 4 (1.9%) patients were malnourished, with albumin levels of less than 3.5 g/dl. The most common type of pancreatic resection was a pylorus-preserving pancreaticoduodenectomy (N = 122/216; 56.5%). Major morbidity and 30-day mortality rates were 11.1% and 1.9%, respectively. The type of surgical procedure (hazard ratio [HR]: 3.849; 95% confidence interval [CI]: 1.208–12.264) and ASA score (HR: 3.089; 95% CI: 1.067–8.947) were significantly associated with the incidence of major postoperative complications in multivariate analysis. The receiver operating characteristic curve was 0.657 for incremental values and 0.559 for risk categories, indicating a weak predictive model.ConclusionThe results of the present study suggest that the PREPARE risk score has low accuracy in predicting the risk of major complications in patients with consistent preoperative nutritional support. This limits the use of PREPARE risk score in future preoperative clinical routines.

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The short- and long-term outcomes of pancreaticoduodenectomy for distal cholangiocarcinoma

Cited by 4 publications

References 48 publications

Comparative Outcomes of Minimally Invasive Versus Open Pancreatoduodenectomy in Distal Cholangiocarcinoma: A Systematic Review and Meta-Analysis

Comparative Outcomes of Minimally Invasive Versus Open Pancreatoduodenectomy in Distal Cholangiocarcinoma: A Systematic Review and Meta-Analysis

DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma

Preoperative nutritional support in patients undergoing pancreatic surgery affects PREPARE score accuracy

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