The Shivering Threshold in Rabbits with JM-1232(−), a New Benzodiazepine Receptor Agonist

Masamune, Taishi; Sato, Hiroaki; Okuyama, Katsumi; Imai, Yusuke; Iwashita, Hironobu; Ishiyama, Tadahiko; Oguchi, Takeshi; Sessler, Daniel I.; Matsukawa, Takashi

doi:10.1213/ane.0b013e3181a1a5ed

Cited by 8 publications

(11 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CMR is associated with a proportional change in CBF. Our preliminary experiment and our previous study [ 11 ] showed that JM-1232(-) decreases BIS values. BIS is commonly used to measure hypnotic effect, and appears reliable in rabbits [ 12 ].…”

Section: Discussionsupporting

confidence: 49%

“…JM-1232(-) has sedative and anesthetic properties, however, sedative and anesthetic doses of JM-1232(-) for rabbits have not been well documented. Masamune et al [ 11 ] reported that intravenous administration of JM-1232(-) at 0.01 mg/kg/min and 0.1 mg/kg/min combined with 0.2 minimum alveolar concentration of isoflurane reduced bispectral index (BIS) values in rabbits. However, BIS level at 0.01 mg/kg/min infusion and at 0.1 mg/kg/min infusion did not differ significantly [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Masamune et al [ 11 ] reported that intravenous administration of JM-1232(-) at 0.01 mg/kg/min and 0.1 mg/kg/min combined with 0.2 minimum alveolar concentration of isoflurane reduced bispectral index (BIS) values in rabbits. However, BIS level at 0.01 mg/kg/min infusion and at 0.1 mg/kg/min infusion did not differ significantly [ 11 ]. Although the BIS algorithm of humans may not be applicable to rabbits, JM-1232(-) at 0.01 mg/kg/min probably has sedative property and that at 0.1 mg/kg/min has anesthetic property in rabbits if isoflurane would be inhaled.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The effects of topical and intravenous JM-1232(-) on cerebral pial microvessels of rabbits

et al. 2015

Self Cite

View full text Add to dashboard Cite

BackgroundJM-1232(-) is a novel anesthetic agent which acts through gamma-aminobutyric acid receptors. Cerebral pial vascular effects of JM-1232(-) are unknown. We thus evaluated topical and intravenous effects of JM-1232(-) on cerebral pial microvessels in rabbits, and the extent to which carbon dioxide (CO2) reactivity is preserved.MethodsClosed cranial windows were used to visualize cerebral pial circulation in 29 Japanese white rabbits. In the first experiment, the cranial window was superfused with increasing concentrations of JM-1232(-): 10-11, 10-9, 10-7, 10-5 mol/L, n = 8 per concentration. In the second experiment, we examined the effects of an intravenous bolus of 1 mg/kg bolus of JM-1232(-), followed by the continuous infusion at 0.3 mg/kg/minute on cerebral pial vascular alteration (n = 9). In the third, we examined CO2 reactivity of cerebral pial vessels under JM-1232(-) (n = 6) or sevoflurane anesthesia (n = 6).ResultsTopical application of JM-1232(-) did not change pial venular diameter, and constricted arterials only at the highest concentration. Intravenous administration of JM-1232(-) produced cerebral pial constriction which gradually diminished over time. Under intravenous administration of JM-1232(-) and inhaled sevoflurane, diameters of vessels increased in parallel with CO2 partial pressure. Slopes of linear regression and correlation coefficients in arterioles and venules were comparable for JM-1232(-) anesthesia and sevoflurane anesthesia.ConclusionsTopical application of JM-1232(-) had little effect on cerebral pial vessels. Intravenous administration produced vasoconstriction of cerebral pial arterioles and venules, however those changes were clinically unimportant. In addition, JM-1232(-) did not impair CO2 responsiveness. At least from the perspective of vascular reactivity, JM-1232(-) thus appears safe for neurosurgical patients.

show abstract

Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of topical and intravenous JM-1232(-) on cerebral pial microvessels of rabbits

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…One rabbit in the control group was excluded because of severe hyperglycemia, to approximately 300 mg dL − 1 . Two rabbits in the severe hypoglycemic group did not shiver at the time when the core temperature reached to 34 °C, accordingly they were treated as if they had shivered at 34 °C as in our previous study [18]. Characteristic data prior to cooling for each group are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Animals were prepared as our previous studies [17, 18]. Briefly, we anaesthetized a rabbit by inhalation of 4% isoflurane and 67% nitrous oxide with oxygen.…”

Section: Methodsmentioning

confidence: 99%

Severe hypoglycemia reduces the shivering threshold in rabbits

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background We previously reported that each 100 mg dL − 1 reduction in blood glucose over the range from ≈90 to > 300 mg dL − 1 decreases the shivering threshold (triggering core temperature) in rabbits by 1 °C. However, the effects of lower blood glucose concentrations has yet to be evaluated. We thus evaluated the relationship between the shivering threshold and blood glucose concentration over the mild-to-severe hypoglycemic range. Methods Thirty-nine rabbits were lightly anaesthetized with isoflurane and randomly assigned to one of the three groups: 1) severe hypoglycemia, insulin and dextrose infusions titrated to achieve blood glucose concentration at 45–75 mg dL − 1 ; 2) mild hypoglycemia, insulin and dextrose infusions titrated to achieve blood glucose concentration at 75–100 mg dL − 1 ; and 3) saline infusion. Cooling by colonic perfusion of water at 10 °C was continued until shivering occurred or esophageal core temperatures reached to 34 °C. Results The shivering threshold in the severe hypoglycemic rabbits was 35.7 ± 1.1 °C (mean ± SD); the thresholds in the mild hypoglycemic rabbits was 37.0 ± 0.7 °C; and the threshold in the control rabbits was 37.9 ± 1.0 °C. The shivering threshold increased linearly with blood glucose concentration: shivering threshold (°C) = 0.032 ∙ [blood glucose concentration (mg dL − 1 )] + 34.1, R 2 = 0.45. The shivering threshold thus decreased by approximately 1 °C for each 31 mg dL − 1 decrease in blood glucose concentration. Conclusions There was a linear relationship between blood glucose and the shivering threshold over the range from severe hypoglycemia to normoglycemia. Blood glucose perturbations in the hypoglycemic range reduced the shivering threshold about three times as much as previously reported for the hyperglycemic range.

show abstract

Effect of JM-1232(-), a New Sedative on Central Respiratory Activity in Newborn Rats

Kuribayashi

Kuwana

Hosokawa

et al. 2009

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

JM-1232(-), a newly manufactured isoindole derivative, shows sedative effect at a lower concentration compared with propofol. In the present study, we analyzed the response of the central respiratory activity to JM-1232(-). The brainstem-spinal cord of a newborn rat was isolated and was continuously superfused with oxygenated artificial cerebrospinal fluid (ACSF). Rhythmic inspiratory burst activity was recorded from C4 spinal ventral root using a glass suction electrode. We measured C4 burst rate and amplitude of integrated C4 activity. After obtaining a control recording, the preparation was superfused with ACSF containing JM-1232(-) at 10, 100 or 500 microM for 10 min. The application of both 10 and 100 microM JM-1232(-) did not decrease C4 burst rate significantly. However, 500 microM JM-1232(-) reduced C4 burst rate. On the contrary, C4 burst amplitude was not affected by the application of JM-1232(-) for 10 min at any concentrations. In conclusion, JM-1232(-) at a low concentration (but presumably higher than hypnotic dose), did not depress the central respiratory activity, whereas at a high concentration depression was seen.

show abstract

The Shivering Threshold in Rabbits with JM-1232(−), a New Benzodiazepine Receptor Agonist

Cited by 8 publications

References 31 publications

The effects of topical and intravenous JM-1232(-) on cerebral pial microvessels of rabbits

The effects of topical and intravenous JM-1232(-) on cerebral pial microvessels of rabbits

Severe hypoglycemia reduces the shivering threshold in rabbits

Effect of JM-1232(-), a New Sedative on Central Respiratory Activity in Newborn Rats

Contact Info

Product

Resources

About