The shell game: patterning genes and morphological change

Berg, Celeste A.

doi:10.1016/j.tig.2005.04.010

Cited by 121 publications

(131 citation statements)

References 94 publications

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“…Thus, each ovariole contains an array of developmentally ordered egg chambers. In the meroistic polytrophic ovarioles of Drosophila melanogaster and Ceratitis capitata, each egg chamber consists of 16 germ line cells (15 nurse cells and 1 oocyte), surrounded by a monolayer of somatic epithelial cells, called follicle cells (Trougakos and Margaritis, 2002;Berg, 2005). The nurse cells support the development of the oocyte providing organelles, proteins and maternal RNAs to the oocyte through the ring canals (Mahajan-Miklos and Cooley, 1994;Trougakos and Margaritis, 2002).…”

Section: Introductionmentioning

confidence: 99%

Stage-specific regulation of programmed cell death during oogenesis of the medfly Ceratitis capitata (Diptera, Tephritidae)

Velentzas¹,

Nezis²,

Stravopodis³

et al. 2007

Int. J. Dev. Biol.

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In the present study, we describe novel features of programmed cell death in developing egg chambers occurring during mid-and late-oogenesis of the medfly Ceratitis capitata. During mid-oogenesis, the spontaneously degenerated egg chambers exhibit typical characteristics of apoptotic cell death. Their nurse cells contain fragmented DNA and fragmented actin, as revealed by TUNEL assay and immunolabelling, respectively. In vitro caspase activity assays and immunostaining procedures demonstrated that the atretic egg chambers acquired high levels of caspase activity. Distinct features of autophagic cell death were also observed during C. capitata mid-oogenesis, as revealed by the monodansylcadaverine staining approach and ultrastructural examination performed by transmission electron microscopy. Additionally, atretic egg chambers exhibit an upregulation of lysosomal proteases, as demonstrated by a procathepsin L immunolabelling procedure. At the late stages of C. capitata oogenesis, apoptosis and autophagy coexist, manifesting cell death features that are similar to the ones mentioned above, being also chaperoned by the involvement of an altered cytochrome c conformational display. We propose that apoptosis and autophagy operate synergistically during C. capitata oogenesis for a more efficient elimination of the degenerated nurse cells and abnormal egg chambers.

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Section: Introductionmentioning

confidence: 99%

Stage-specific regulation of programmed cell death during oogenesis of the medfly Ceratitis capitata (Diptera, Tephritidae)

Velentzas¹,

Nezis²,

Stravopodis³

et al. 2007

Int. J. Dev. Biol.

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“…18w-expressing cells contribute to dorsal appendage synthesis and subtle appendage defects are observed when that contribution is missing. Ultimately, we wish to understand how 18w contributes to the extremely complex signaling that occurs in the dorsal anterior region of the mid-to late-stage egg chamber to execute the elaborate morphogenetic events of eggshell patterning (Dobens and Raftery, 2000;Berg, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…How are these processes regulated at the molecular level? The somatic follicle cells in the Drosophila ovary are a wellcharacterized polarized epithelium in which these questions can be successfully addressed (Montell, 2003;Berg, 2005;Horne-Badovinac and Bilder, 2005). The viability, morphogenesis, and polarity of the egg chamber rely on the integrity of the polarized epithelium and extensive signaling among follicle cells and between follicle and germ line cells.…”

Section: Introductionmentioning

confidence: 99%

“…The border cells reach the oocyte during stage 10, migrate dorsally to a position near the oocyte nucleus, and participate in eggshell synthesis by forming the pore in the micropyle through which the sperm will enter the egg (Montell et al, 1992). Cells on the dorsal anterior side of the egg undergo dramatic morphological movements resulting in the secretion of a pair of dorsal respiratory appendages (Berg, 2005). During stage 14, the follicle cells undergo apoptosis and are lost from the egg as it moves down the oviduct (Nezis et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…The elaborate signaling mechanisms that govern follicle cell migration, particularly of the border cells and those secreting dorsal appendages, have been studied in some detail (Dorman et al, 2004;Starz-Gaiano and Montell, 2004;Berg, 2005;Ward and Berg, 2005). Mutations causing defects in the integrity or epithelial polarity of the follicle cells frequently lead to over-proliferation, as well as disorganized, multilayered growth and subsequent degeneration of the egg chamber during mid-oogenesis (reviewed by Mü ller, 2000;Tepass et al, 2001;Bilder, 2004;Horne-Badovinac and Bilder, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Expression of 18‐wheeler in the follicle cell epithelium affects cell migration and egg morphology in Drosophila

Kleve

Siler

Syed

et al. 2006

Developmental Dynamics

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The Drosophila ovary is a model system for examining the genetic control of epithelial morphogenesis. The somatic follicle cells form a polarized epithelium surrounding the 16-cell germ line cyst. The integrity of this epithelium is essential for the successful completion of oogenesis. Reciprocal signaling between germ line and somatic cells establishes embryonic and eggshell polarity. The follicle cells are responsible for shaping the egg and secreting the eggshell. Follicle cells at the boundary between the nurse cells and the oocyte migrate centripetally to cover the anterior end of the oocyte and secrete the operculum. Dorsal anterior main body follicle cells undergo elaborate patterning to produce the dorsal appendages. We have examined the expression of the Toll-like receptor, 18-wheeler (18w), in the ovary and find it to be restricted to subpopulations of follicle cells. Females carrying loss-of-function 18w mutant clones in their ovaries show delayed follicle cell migrations. The eggs laid by such females also show morphological defects in egg shape and dorsal appendage morphology. We propose that the 18W protein plays an adhesive or signaling role in regions of the epithelium engaged in cell migration.

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Ras signaling modulates activity of the ecdysone receptor EcR during cell migration in the drosophila ovary

Hackney

Pucci

Naes

et al. 2007

Developmental Dynamics

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Ecdysone Receptor (EcR) mediates effects of the hormone ecdysone during larval molts, pupal metamorphosis, and adult female oogenesis. In the ovary, egg chamber formation requires interactions between the somatic follicle cell (FC) epithelium and the germ line nurse cell/oocyte cyst. Previous work has shown EcR is required in the germ line for egg chamber maturation, and here we examine EcR requirements in the FC at late stages of oogenesis. EcR protein is ubiquitous in the FC but its activity is restricted, visualized by activity of the "ligand sensor" hs-GAL4-EcR ligand binding domain fusion and

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The shell game: patterning genes and morphological change

Cited by 121 publications

References 94 publications

Stage-specific regulation of programmed cell death during oogenesis of the medfly Ceratitis capitata (Diptera, Tephritidae)

Stage-specific regulation of programmed cell death during oogenesis of the medfly Ceratitis capitata (Diptera, Tephritidae)

Expression of 18‐wheeler in the follicle cell epithelium affects cell migration and egg morphology in Drosophila

Ras signaling modulates activity of the ecdysone receptor EcR during cell migration in the drosophila ovary

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