The sheep as a model for temporomandibular joint surgery

Bosanquet, Arthur G.; Goss, Alastair N.

doi:10.1016/s0901-5027(87)80113-3

Cited by 74 publications

(17 citation statements)

References 2 publications

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“…Porous SF cylinders of the four groups (Table 1) were distributed randomly to eight predefined metaphyseal or epiphyseal locations in long bones of the sheep, namely left and right proximal humerus, proximal femur, proximal tibia, and distal femur [22,24]. Therefore, two repetitions of each of the four treatment groups were implanted in each sheep.…”

Section: Scaffold Locationmentioning

confidence: 99%

“…In order to evaluate the effect of the proposed processing parameters on the performance and biocompatibility of SF scaffolds in one single experiment, the sheep drill hole model was used, representing a relevant in vivo animal model that allows for the reduction in animal numbers but still satisfying statistical requirements [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biocompatibility and osteoconduction of macroporous silk fibroin implants in cortical defects in sheep

Uebersax

Apfel²,

Nuss³

et al. 2013

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Scaffold Locationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biocompatibility and osteoconduction of macroporous silk fibroin implants in cortical defects in sheep

Uebersax

Apfel²,

Nuss³

et al. 2013

European Journal of Pharmaceutics and Biopharmaceutics

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“…Condylar secondary cartilage has been shown to be sensitive to epigenetical factors such as hormonal influences (7) as well as mechanical loadings exerted by functional changes (8,9). His-tological investigations of temporomandibular joints from various mammalian groups, such as omnivores represented by humans (10,11), primates (12,13), ungulate herbivores such as sheep (14,15) and goat (16), as well as rodents such as guinea pigs (17) and rats (18,19), have failed to substantiate these proposed associations between biomechanical factors and microanatomy, and revealed the same general cellular organization of the condylar articular cartilage despite different macroanatomical features and functional performances. In all these investigated species, the condylar articular cartilage could be separated into a fibrous articular layer, a mitotic proliferative zone, followed by first hypertrophied cartilage cells and further down mineralized cartilage and, finally, a zone of endochondral bone formation.…”

mentioning

confidence: 99%

Microanatomy of the moose temporomandibular joint (Alces alces; Linnaeus, 1758)

Ström

Sato

Magnusson

1996

European J Oral Sciences

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Temporomandibular joint (TMJ) histology was investigated in 8 female Scandinavian moose. 5 were 1-year-old with a carcass weight (cw) of 125-140 kg, and 3 were 2-years-old (160-175 kg cw). The condylar articular surface consisted of a connective tissue lining with parallel collagen fibres. Numerous blood vessels were observed adjacent to the joint chamber. Below the fibrous layer, a proliferative cellular zone of undifferentiated mesenchymal cells was situated. These cells differentiated into chondroblasts and hypertrophied chondrocytes. Further down, an endochondral ossification process was initiated. Vertically directed invaginations were observed. A similar cellular organization was identified in the temporal component. However, the undifferentiated mesenchymal cell layer was discontinuous. The disc showed dense collagen bundles without main alignment. Vessels were identified throughout the entire disc. The results indicate that the cellular organization of the moose TMJ is similar to the TMJ histology found in other mammals but differences do occur.

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“…This is the primary plane of jaw motion in the goat and is the motion in which disc movements most resemble those observed in humans (Bosanquet and Goss 1987;Bifano et al 1994). This is the primary plane of jaw motion in the goat and is the motion in which disc movements most resemble those observed in humans (Bosanquet and Goss 1987;Bifano et al 1994).…”

Section: Monitoring and Control Of Jaw Movementmentioning

confidence: 87%

The development of strains, forces and nociceptor activity in retrodiscal tissues of the temporomandibular joint of male and female goats

et al. 1997

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Chronic pain in the temporomandibular (TM) joint is predominantly manifested in women. We examined biomechanical and neural factors that could contribute to this differential representation. Relationships between jaw rotation, soft tissue strains and soft tissue forces were examined in the goat TM joint. Strains were minimal until the jaw was rotated beyond the normal range of motion (7.25 deg). There were no significant differences in rotation-strain patterns in males and females. Stress developed as strains were introduced by jaw rotation. Gender differences were observed. Males manifested higher failure loads (15.94 +/- 1.98 and 11.37 +/- 2.02 N, for males and females respectively) and higher elastic stiffness than females (5.62 +/- 1.19 N/mm and 1.64 +/- 0.31 N/mm, for males and females respectively). Recordings were made from cell bodies in the trigeminal ganglion whose distal processes innervated the retrodiscal tissue of the temporomandibular joint of the goat (n = 48). Nociceptor reactivity was characterized with respect to the capacity to transduce mandibular rotation (rotation-interval functions; n = 29). On the basis of established relationships between rotation, strain and tissue forces, rotation-interval functions were transformed into strain-interval and force-interval functions. Comparisons were made between nociceptor properties grouped by gender. No differences in properties were observed when nociceptors were characterized with respect to jaw rotation; however, gender differences were obtained when nociceptor reactivity was characterized with respect to retrodiscal strains or forces. Consistent with smaller failure loads, nociceptors of retrodiscal tissues of females manifested a smaller range (1.12 vs 4.33 N), force to average (1.51 vs 4.64 N), force to minimum (0.95 vs 2.48 N) and force to asymptotic discharge (2.07 vs 6.81 N). Consistent with lower elastic stiffness, nociceptors of female tissues manifested higher average strain (54.4% vs 41.9%) and peak strain (74.0% vs 58.1%) to asymptotic discharge relative to those sampled from male tissues. The implications of these findings for TM joint injury and chronic pain are considered.

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The sheep as a model for temporomandibular joint surgery

Cited by 74 publications

References 2 publications

Biocompatibility and osteoconduction of macroporous silk fibroin implants in cortical defects in sheep

Biocompatibility and osteoconduction of macroporous silk fibroin implants in cortical defects in sheep

Microanatomy of the moose temporomandibular joint (Alces alces; Linnaeus, 1758)

The development of strains, forces and nociceptor activity in retrodiscal tissues of the temporomandibular joint of male and female goats

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