The Shanghai Aging Study: Study Design, Baseline Characteristics, and Prevalence of Dementia

Abstract

Background: To establish a prospective cohort to enumerate the prevalence, incidence and risk factors for dementia and mild cognitive impairment (MCI) among residents aged ≥60 in an urban community of Shanghai, China. Methods: Participants received clinical evaluations including physical measurements, demographic and lifestyle questionnaires, physical and neurologic examinations, and neuropsychological testing. Urine and blood samples were collected, aliquoted, and stored. DNA was extracted for Apolipoprotein (APOE) genotyping. Diagnoses of dementia and MCI were made using standard criteria via consensus diagnosis. Results: Among 3,141 participants aged ≥60, 1,438 (45.8%) were men. The average age of participants was 72.3 years (SD 8.1), and they had an average of 11.6 years (SD 4.4) of education. The most common chronic disease of participants was hypertension (56.4%). The frequencies of APOE-​ε2, ε3 and ε4 were 7.9, 82.7 and 9.4%, respectively. We diagnosed 156 (5.0%, 95% CI 4.3-5.8%) participants with dementia. The prevalence rates of Alzheimer's disease and vascular dementia were 3.6% (95% CI 3.0-4.3%) and 0.8% (95% CI 0.5-1.1%). Conclusions: The Shanghai Aging Study is the first prospective community-based cohort study of cognitive impairment in China, with a comparable study design, procedures, and diagnostic criteria for dementia and MCI to most previous cohort studies in developed countries.

Screening for Dementia in Older Adults: Comparison of Mini-Mental State Examination, Mini-Cog, Clock Drawing Test and AD8

“…Early detection of dementia in a preclinical phase is very important and a quick, cheap and practical screening test for dementia among healthy people is needed [24]. Using brief cognitive screening tools enabled us to detect dementia and mild cognitive impairment at the earliest stages [22, 25].…”

Diabetes is Associated with Worse Executive Function in Both Eastern and Western Populations: Shanghai Aging Study and Mayo Clinic Study of Aging

“…The initial inclusion age criterion was initially ≥ 60 years old, and has recently been broadened to 50 years and older. Consequently, 3348 non-demented SAS participants were included in this study [11]. Details of these studies design and participant recruitment are described elsewhere [11–13].…”

“…Consequently, 3348 non-demented SAS participants were included in this study [11]. Details of these studies design and participant recruitment are described elsewhere [11–13]. The Mayo Clinic Study of Aging (MCSA) was established to estimate the prevalence and incidence of MCI and to identify risk factors for MCI and dementia[14].…”

Associations of childhood socioeconomic status with mid‐life and late‐life cognition in Chinese middle‐aged and older population based on a 5‐year period cohort study

“…Accumulating evidence has examined in developed countries that life‐course drivers played important roles in cognition. However, little research has investigated these associations in elder population in developing countries, such as China, which is one of the most rapidly aging societies in Asia, facing a great threat of dementia . Thus, an additional examination of this issue targeting Chinese appeared to be warranted.…”