The sex-specific association between maternal urinary paraben levels and offspring size at birth

Hajizadeh, Yaghoub; Moradnia, Maryam; Feizabadi, Ghasem Kiani; Rafiei, Nasim; Tahmasbizadeh, Masoumeh; Darvishmotevalli, Mohammad; Fadaei, Saeid; Karimi, Hossein

doi:10.1007/s11356-021-13175-3

Cited by 18 publications

(14 citation statements)

References 54 publications

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“… 13 Previous studies have reported that exposure to parabens during pregnancy showed an association with fetus growth indicators, including exposure to methylparaben and propylparaben decreasing the head circumference of the fetus. 14 The urinary concentration of EDCs also showed statistically significant positive correlation with each other among pregnant women, indicating that those who are vulnerable to exposure to one type of EDC are also at higher risk for exposure to another type of EDC. 15 …”

Section: Introductionmentioning

confidence: 90%

Interventions on Reducing Exposure to Endocrine Disrupting Chemicals in Human Health Care Context: A Scoping Review

Park¹,

Lee²,

Lee³

et al. 2022

RMHP

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Purpose Inevitability of exposure to endocrine disrupting chemicals (EDCs) in daily lives of modern society is increasing interests in developing and implementing interventions to prevent or reduce harmful health effects of EDCs in various academic areas. This is a scoping review of intervention studies aimed at reducing exposure to EDCs in the text of human health care. Methods Scoping review methodology was used to explore the extent, range, and nature of current literature. A comprehensive systematic search of PubMed, CINAHL, Cochrane, PcycINFO, EMBASE, and RISS was performed for studies published to date. The authors followed Arksey and O’Malley’s stages; 1) identification of research questions; 2) identification of relevant studies using a total of six electronic databases; 3) study selection; 4) charting the data; and 5) collation, summarization and reporting of the data. Results A total of 2114 articles were retrieved, from which 13 articles were included in the final review. Among the 13 studies, 12 conducted interventions regarding dietary modification or replacement of household or personal goods. The duration of interventions ranged from at least three days to a maximum of six months, including six studies with a period of less than ten days. The participants were all healthy populations, eight of which were for adults, three for children or adolescents, and two for families. Outcome of the interventions were measured through concentration of EDCs in urine or/and house air. The effects of the interventions were inconsistent, with 11 studies showing significant changes of EDC concentration while no significant change was found in two studies. Conclusion The results indicate a need for randomized controlled trials, participant-centered studies promoting active participation and practices of subjects, studies specifying subgroups of participants, and studies including families as units in interventions.

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Section: Introductionmentioning

confidence: 90%

Interventions on Reducing Exposure to Endocrine Disrupting Chemicals in Human Health Care Context: A Scoping Review

Park¹,

Lee²,

Lee³

et al. 2022

RMHP

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“…4 Butylparaben was associated with decreased abdominal circumference at third trimester in females, an effect not observed previously, 2 and decreased female weight at birth. For the latter outcome, a positive effect was estimated regardless of sex, 39,40 in boys, [39][40][41][42] and girls. 39,43 Other studies reported no association when both sexes were studied together, 41,44,45 or when only boys were considered.…”

Section: Parabensmentioning

confidence: 99%

“…For the latter outcome, a positive effect was estimated regardless of sex, 39,40 in boys, [39][40][41][42] and girls. 39,43 Other studies reported no association when both sexes were studied together, 41,44,45 or when only boys were considered. 4,46 It should be noted that detection rate of butylparaben in our study was relatively low, which could partially explain discrepancies in the results.…”

Section: Parabensmentioning

confidence: 99%

Pregnancy Exposure to Phenols and Anthropometric Measures in Gestation and at Birth

Jedynak¹,

Rolland²,

Pin³

et al. 2022

Epidemiology

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Background: Some synthetic phenols alter pathways involved in fetal development. Despite their high within-subject temporal variability, earlier studies relied on spot urine samples to assess pregnancy exposure. In this study, we examined associations between prenatal phenol exposure and fetal growth. Methods: We measured concentrations of two bisphenols, four parabens, benzophenone-3, and triclosan in 478 pregnant women in two weekly pools of 21 samples each, collected at 18 and 34 gestational weeks. We used adjusted linear regressions to study associations between phenol concentrations and growth outcomes assessed twice during pregnancy and at birth. Results: Benzophenone-3 was positively associated with all ultrasound growth parameters in at least one time point, in males but not females. In females, butylparaben was negatively associated with third-trimester abdominal circumference and weight at birth. We observed isolated associations for triclosan (negative) and for methylparaben and bisphenol S (positive) and late pregnancy fetal growth. Conclusions: Our results suggest associations between prenatal exposure to phenols and fetal growth. Benzophenone-3 was the exposure most consistently (positively) associated across all growth parameters.

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“…The study population was selected from the participants in the PERSIAN (Prospective Epidemiological Research Studies in IRAN) Birth Cohort (Sakhvidi et al 2021;Hajizadeh et al 2021). This cohort study evaluates the associations of socio-economic characteristics, lifestyle, diet, environmental exposures, and epigenetic factors with pregnancy outcomes, mother and child mental and physical health and well-being, child neurodevelopment, and risk factors for the establishment of chronic diseases.…”

Section: Study Populationmentioning

confidence: 99%

“…These make pregnant women and their offspring one of the most vulnerable groups in exposure to these pollutants all over the world (Long et al 2019). Although correlations of exposure to other pollutants such as heavy metals (Wai et al 2017;Moradnia et al 2021), parabens (Hajizadeh et al 2021), bisphenol a (Wan et al 2018;Zhou et al 2019), and phthalate (Santos et al 2021) with offspring birth outcomes have been reported, studies on the effects of BPs on pregnant women and their infants are not conclusive. However, the available evidence has shown that BPs by disrupting hormonal activities and inflammatory responses can impact the duration of pregnancy (Wolff et al 2008;Tang et al 2013;Aker et al 2016Aker et al , 2019.…”

Section: Introductionmentioning

confidence: 99%

The association of prenatal exposure to benzophenones with gestational age and offspring size at birth

Teiri

Samaei

Dehghani

et al. 2021

Environ Sci Pollut Res

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In recent decades, emerging environmental pollutants such as endocrine-disrupting chemicals (EDCs) have become a particular concern. This study examined the association of maternal exposure to benzophenones as one of the EDCs with gestational age and evaluated their effects on birth outcomes including birth weight, birth length, head circumference, and Ponderal Index. We assessed 166 pregnant mothers of the PERSIAN cohort population of Isfahan, Iran, in the 1st and 3rd trimesters of pregnancy and their infants at birth. Four common benzophenones (BPs) including 2,4-dihydroxy benzophenone (BP-1), 2-hydroxy-4-methoxy benzophenone (BP-3), 4-hydroxy benzophenone (4-OH-BP), and 2,2′-dihydroxy-4-methoxy benzophenone (BP-8) were measured in maternal urine samples. The median urinary concentrations of 4-OH-BP, BP-3, BP-1, and BP-8 in the 1st trimester were 6.62, 7.5, 4.39, and 1.32 µg/g creatinine and those in the 3rd trimester were 3.15, 16.98, 9.95, and 1.04 µg/g creatinine, respectively. BP-3 was the predominant metabolite in both trimesters. There was a significant correlation between BP-3, BP-1, and 4-OH-BP levels (p < 0.05) but not BP-8. BP-1 showed a significant positive association with gestational age (GA) in all infants in the 1st trimester, but a negative association was observed between BP-3 and BP-1 levels and GA in girls. Classification of infants' birth weight for different GAs represented that the majority of them were appropriate for GA. However, boys' weights were heavier than girls. Also, birth outcomes of preterm (< 37 weeks) infants were noticeably lower than term infants (37-42 weeks). This study demonstrated that benzophenone derivatives especially BP-3 can affect the duration of pregnancy and consequently fetal growth in the early and late stages of pregnancy. This is more pronounced in girls; however, more investigations in a different population are needed to prove the results. Therefore, the application of these compounds as a UV protector requires precise regulation to reduce exposure, especially in pregnant women.

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The sex-specific association between maternal urinary paraben levels and offspring size at birth

Cited by 18 publications

References 54 publications

Interventions on Reducing Exposure to Endocrine Disrupting Chemicals in Human Health Care Context: A Scoping Review

Interventions on Reducing Exposure to Endocrine Disrupting Chemicals in Human Health Care Context: A Scoping Review

Pregnancy Exposure to Phenols and Anthropometric Measures in Gestation and at Birth

The association of prenatal exposure to benzophenones with gestational age and offspring size at birth

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