The seventh pandemic of cholera in Europe revisited by microbial genomics

Oprea, Mihaela; Njamkepo, Elisabeth; Cristea, Dana; Zhukova, Anna; Clark, Clifford G.; Kravetz, Anatoly N.; Монахова, Е. В.; Ciontea, Adriana Simona; Cojocaru, Radu; Rauzier, Jean; Damian, Maria; Gascuel, Olivier; Quilici, Marie‐Laure; Weill, François‐Xavier

doi:10.1038/s41467-020-19185-y

Cited by 17 publications

(29 citation statements)

References 44 publications

(80 reference statements)

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“…The 2018 isolates did not belong to sublineages previously found in Algeria, including AFR1, which circulated during the 1970s and early 1980s; AFR7, which circulated during the mid-to late-1980s and early 1990s; or AFR8 and AFR9, which circulated during the mid-1990s (Figures 1, 2) (8). The 2018 isolates also did not belong to other sublineages found in Africa, including the most recently introduced AFR13 sublineage, previously known as T13 (8)(9)(10)(11). AFR13 has been circulating in eastern Africa since 2015 and in Yemen since 2016 (Figure 1).…”

Section: The Studymentioning

confidence: 69%

Outbreak of Imported Seventh Pandemic Vibrio cholerae O1 El Tor, Algeria, 2018

Benamrouche¹,

Belkader²,

Njamkepo³

et al. 2022

Emerg. Infect. Dis.

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Section: The Studymentioning

confidence: 69%

Outbreak of Imported Seventh Pandemic Vibrio cholerae O1 El Tor, Algeria, 2018

Benamrouche¹,

Belkader²,

Njamkepo³

et al. 2022

Emerg. Infect. Dis.

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“…Such aspects are described for Vibrio species isolated from aquatic environments (surface water, sediment) and habitats from several regions [ 27 , 38 , 39 , 40 ] but no report characterizes the presence of Vibrio spp. strains isolated from wild birds captured in different locations of the Danube Delta, Romania.…”

Section: Introductionmentioning

confidence: 99%

Assessment and Antibiotic Resistance Profiling in Vibrio Species Isolated from Wild Birds Captured in Danube Delta Biosphere Reserve, Romania

et al. 2021

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Antimicrobial and multidrug-resistant bacteria are a major problem worldwide and, consequently, the surveillance of antibiotic-resistant bacteria and assessment of the dissemination routes are essential. We hypothesized that migratory birds, coming from various environments, would carry more numerous Vibrio strains than sedentary species, with increased risk to be passed to their contacts or environment in habitats they transit or nest in. Similarly, we presumed that strains from migratory birds will show multidrug resistance. A total of 170 oral and rectal swabs were collected from wild birds captured in different locations of the Danube Delta (Malic, Sfantu-Gheorghe, Letea Forest) and processed using standardized selective media. V. cholerae strains were confirmed by serology and molecular methods and, subsequently, their susceptibility was evaluated. The prevalence of Vibrio species by host species, habitat type, and location was interpreted. The isolated Vibrio species were identified as Vibrio cholerae 14.33%, V. fluvialis 13.33%, V. alginolyticus 12%, V. mimicus 17.33%, V. vulnificus 10.88%, with V. parahaemolyticus and V. metschnikovii (16%) also being prevalent. Of the 76 Vibrio spp. isolates, 18.42% were resistant towards at least three antimicrobials, and 81.57% demonstrated a multidrug resistance phenotype, including mainly penicillins, aminoglycosides, and macrolides. The results of the present study indicate higher numbers of Vibrio strains in migratory (74.66%) than in sedentary birds (25.33%), confirming our hypothesis. Furthermore, the increased pathogenicity of Vibrio spp. strains, isolated from wild migratory and sedentary birds, was confirmed by their increased multiple antibiotic resistance (MAR) index (0.09–0.81).

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“…The dates of introduction of the different sublineages are also shown. These data were taken from the following references [26,30,[36][37][38][39].…”

Section: Genetic Evolution and Spread Of The 7pet Lineagementioning

confidence: 99%

Contribution of microbial genomics to cholera epidemiology

Rouard¹,

Njamkepo²,

Quilici³

et al. 2022

Comptes Rendus. Biologies

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In 2022, the burden of cholera-an acute watery diarrheal disease caused by Vibrio cholerae serogroup O1 (or more rarely O139) bacteria, which produce cholera toxin-remains high in many African and Asian countries. In the last few years, microbial genomics has made it possible to define the bacterial populations responsible for cholera more precisely. It has been shown that the current, seventh pandemic is due to a single lineage with a reservoir in the countries of the Bay of Bengal (India and Bangladesh). There have been several transmissions of the causal agent of cholera from this region to Africa, Asia and Latin America, suggesting a human-to-human transmission of the disease. Microbial genetics can help to fight this scourge by providing insight into cholera epidemiology and through its use in disease monitoring, thereby contributing to the achievement of the World Health Organization's goal of reducing cholera deaths by 90% by 2030.

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The seventh pandemic of cholera in Europe revisited by microbial genomics

Cited by 17 publications

References 44 publications

Outbreak of Imported Seventh Pandemic Vibrio cholerae O1 El Tor, Algeria, 2018

Outbreak of Imported Seventh Pandemic Vibrio cholerae O1 El Tor, Algeria, 2018

Assessment and Antibiotic Resistance Profiling in Vibrio Species Isolated from Wild Birds Captured in Danube Delta Biosphere Reserve, Romania

Contribution of microbial genomics to cholera epidemiology

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