The serum zinc, copper, iron, and chromium concentrations in epileptic children

Wójciak, R.W.; Mojs, Ewa; Stanisławska–Kubiak, Maia; Samborski, Włodzimierz

doi:10.1016/j.eplepsyres.2012.09.009

Cited by 49 publications

(40 citation statements)

References 30 publications

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“…Synaptically-released Zn 2+ has been suggested to regulate neuronal excitability and modulate the severity of seizure activity (Vogt et al 2000; Smart et al 2004; Sensi et al 2009). Indeed, genetic removal of synaptic Zn 2+ via ZnT3 deletion leads to enhanced susceptibility to epileptic seizures (Cole et al 1999; Cole et al 2000), and importantly, deficiencies in plasma Zn 2+ levels have been associated with human epileptic disorders (Goldberg et al 1982; Blasco-Ibanez et al 2004; Ganesh et al 2008; Farahani et al 2013; Seven et al 2013; Wojciak et al 2013; Saad et al 2014). Moreover, studies in kindling models of epilepsy suggest that seizure activity can be moderated via Zn 2+ administration (Elsas et al 2009; Baraka et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures

Gilad

Shorer

Ketzef

et al. 2015

Neurobiology of Disease

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The aim of this study was to investigate the role of the synaptic metabotropic zinc receptor mZnR/GPR39 in physiological adaptation to epileptic seizures. We previously demonstrated that synaptic activation of mZnR/GPR39 enhances inhibitory drive in the hippocampus by upregulating neuronal K+/Cl− co-transporter 2 (KCC2) activity. Here, we first show that mZnR/GPR39 knockout (KO) adult mice have dramatically enhanced susceptibility to seizures triggered by a single intraperitoneal injection of kainic acid, when compared to wild type (WT) littermates. Kainate also substantially enhances seizure-associated gamma oscillatory activity in juvenile mZnR/GPR39 KO hippocampal slices, a phenomenon that can be reproduced in WT tissue by extracellular Zn2+ chelation. Importantly, kainate-induced synaptic Zn2+ release enhances surface expression and transport activity of KCC2 in WT, but not mZnR/GPR39 KO hippocampal neurons. Kainate-dependent upregulation of KCC2 requires mZnR/GPR39 activation of the Gαq/phospholipase C/extracellular regulated kinase (ERK1/2) signaling cascade. We suggest that mZnR/GPR39-dependent upregulation of KCC2 activity provides homeostatic adaptation to an excitotoxic stimulus by increasing inhibition. As such, mZnR/GPR39 may provide a novel pharmacological target for dampening epileptic seizure activity.

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Section: Introductionmentioning

confidence: 99%

Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures

Gilad

Shorer

Ketzef

et al. 2015

Neurobiology of Disease

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“…Several studies, including a recent work by our group, reported a significant decrease in serum zinc levels in patients with intractable epilepsy (Kheradmand et al, 2014;Saad et al, 2014;Seven et al, 2013). Other studies found lower levels of zinc in the serum as well as in other tissues (nails and hair) of epileptic patients (Ashraf et al, 1995;Barbeau and Donaldson, 1974;Ilhan et al, 2004;Wojciak et al, 2013). On the basis of previous studies, we hypothesized that children with refractory epilepsy may potentially benefit from oral zinc as an adjunctive to antiepileptic drugs.…”

Section: Discussionmentioning

confidence: 96%

A randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc in children with intractable epilepsy

Saad¹

2015

Functional Neurology

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SummaryThis study was conducted to assess the efficacy of oral zinc supplementation in children with intractable epilepsy. Forty-five children aged between three and 12 years and diagnosed with idiopathic intractable epilepsy at Assiut University Hospital, Assiut, Egypt were recruited. The patients were randomly allocated to two groups: the intervention group received oral zinc supplementation (1 mg/kg/day) while the placebo group received placebo, each for six months. The parents of each child filled in a detailed questionnaire that covered demographic characteristics, type of seizures, frequency, duration of seizures, previous hospital admissions, postictal phenomena and the occurrence of status epilepticus. The primary outcome (frequency of seizures) was compared between the two groups. Zinc supplementation resulted in a significant reduction of seizure frequency in 31% of the treated children. Zinc is an important trace element. Our results suggest that it has mildly beneficial effects in children with intractable epilepsy. We recommend further investigation of oral zinc supplementation as an adjunctive therapy for managing intractable epilepsy in children. Zinc therapy may be an option in treatment protocols for intractable epilepsy in the near future.

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“…Various symptoms can occur when the compensation capability of the human body is exceeded (Wojciak et al, 2013). Deficiency generally manifests through effects on growth and development during infancy, for example no or slow increases in height and weight, and also through retardation in the development of intelligence and a low intelligence quotient in children due to effects on brain development (Moran et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Relationship between zinc and the growth and development of young children

Gao

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The purpose of this study was to evaluate the relationship between zinc and the growth and development of young children. The parents of 8102 young children were surveyed in person by a trained surveyor using structured questionnaires. The hair zinc concentration of the children was determined using an atomic absorption spectrophotometer. The height, weight, sitting height, and head circumference of the children were measured at follow-up visits. There was a positive correlation between hair zinc concentration and adaptive developmental quotient (ADQ; r = 0.3164, P = 0.0272) while no correlation was found between hair zinc concentration and body measurement Z scores or intelligence quotient (IQ). There was a strong positive correlation between hair zinc concentration and weight-for-age Z scores (r = 0.3618, P = 0.0416) and ADQ (r = 0.2761, P = 0.0387) in boys; there was no correlation between hair zinc concentration and body measurement Z scores, IQ, and ADQ in girls. In boys with normal hair zinc levels, ADQ was 9.58 (P = 0.0392), higher than in boys who had 9731 Zinc and growth and development ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 9730-9738 (2015) zinc-deficient hair. In girls with normal hair zinc levels, ADQ was 2.52 (P = 0.0296), lower than in girls with zinc-deficient hair. In conclusion, there is no significant correlation between hair zinc levels and IQ or Z scores for all body measurements in young children.

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The serum zinc, copper, iron, and chromium concentrations in epileptic children

Cited by 49 publications

References 30 publications

Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures

Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures

A randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc in children with intractable epilepsy

Relationship between zinc and the growth and development of young children

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