The serum lipoprotein transport system in health, metabolic disorders, atherosclerosis and coronary heart disease

Gofman, John W.; Delalla, Oliver; Glazier, Frank W.; Freeman, N. K.; Lindgren, Frank T.; Nichols, Alex V.; Strisower, Beverly; Tamplin, Arthur R.

doi:10.1016/j.jacl.2007.03.001

Cited by 58 publications

(43 citation statements)

References 35 publications

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“…19 Several other investigators have reported that hypertriglyceridemia could be involved in the pathogenesis of hypertensive disorders during pregnancy. [19][20][21][22][23] In the present study, we also found a significant and positive association between proteinuria and both triglyceride and VLDL levels. These findings suggest that these lipids may be involved in the endothelial damage observed in our preeclampsia patients.…”

Section: Discussionsupporting

confidence: 73%

“…20 The development of atherosclerosis in the placental spiral arteries of preeclamptic women indicates that elevated levels of triglycerides are involved in this disorder. 25 The fact that the patients with preeclampsia presented dyslipidemia, characterized by high levels of triglycerides and VLDL, indicates that there are common interfaces between preeclampsia and the endothelial lesions that occur in atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

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Serum lipid levels in pregnancies complicated by preeclampsia

et al. 2011

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CONTEXT AND OBJECTIVE: Pre-eclampsia is a disorder that occurs only during pregnancy. Postpartum changes relating to lipid metabolism may contribute towards the endothelial lesions observed in preeclampsia. Thus, the aim of the present study was to evaluate the lipid profile among patients who present preeclampsia and correlate these parameters with 24-hour proteinuria. DESIGN AND SETTING:Cross-sectional analytical study including 77 pregnant patients seen at Hospital Dório Silva. METHODS:This study involved 42 women with preeclampsia and 35 healthy pregnant women in the third trimester of pregnancy as controls. Blood samples were obtained from all the patients, and the serum levels of triglycerides, total cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL) and very low density lipoproteins (VLDL) were determined. Cases and controls were matched for maternal age, gestational week and body mass index. RESULTS:The VLDL and triglyceride values from the women with preeclampsia were significantly higher than those of the healthy women. There was a positive correlation between increased proteinuria and higher VLDL and triglyceride levels in patients with preeclampsia.CONCLUSION: Among the patients with preeclampsia, higher VLDL and triglyceride levels were positively correlated with proteinuria. These observations indicate that the pregnant women who presented elevated lipid levels were more susceptible to cardiovascular disorders and, consequently, preeclampsia. RESUMO CONTEXTO E OBJETIVO:A pré-eclâmpsia é um distúrbio que ocorre apenas durante a gravidez e as alterações pós-parto relacionadas ao metabolismo lipídico podem contribuir para a lesão endotelial observada nessa afecção. Assim, o objetivo do presente estudo foi avaliar o perfil lipídico em pacientes que apresentaram pré-eclâmpsia e correlacionar estes parâmetros com a proteinúria de 24 horas. TIPO DE ESTUDO E LOCAL:Estudo transversal analítico, incluindo 77 pacientes grávidas atendidas no Hospital Dório Silva. MÉTODOS:Este estudo envolveu 42 mulheres com pré-eclâmpsia e 35 gestantes saudáveis no terceiro trimestre de gravidez como controle.Amostras de sangue foram obtidas de todas as pacientes e os níveis séricos de triglicérides, colesterol total, lipoproteínas de baixa densidade (LDL), lipoproteínas de alta densidade (HDL) e lipoproteínas de muito baixa densidade (VLDL) foram determinados. Casos e controles foram pareados por idade materna, semana gestacional e índice de massa corporal.RESULTADOS: Os valores de VLDL e triglicérides, obtidos de mulheres com pré-eclâmpsia foram significativamente maiores quando comparados com mulheres saudáveis. Houve uma correlação positiva entre o aumento da proteinúria e concentrações elevadas de VLDL e triglicérides, em pacientes com pré-eclâmpsia.CONCLUSÃO: Nas pacientes com pré-eclâmpsia foram observadas as maiores concentrações de VLDL e os níveis de triglicérides estão correlacionados positivamente com proteinúria. Estas observações indicam que as mulheres grávidas que apresentam ní...

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Serum lipid levels in pregnancies complicated by preeclampsia

et al. 2011

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“…In his 1965 Lyman Duff Lecture, John Gofman, who originally proposed that S f 20 -400 lipoproteins are more atherogenic than LDL (weight for weight), 118 reported that prospective data from Framingham and Livermore failed to support this concept. 119 (Footnote 2 ) For many years plasma triglycerides, as a surrogate for TRL, did not fare much better, owing in part to the log-linear inverse relationship between plasma triglycerides and HDLcholesterol levels.…”

Section: Triglyceride-rich Lipoproteins and Atherosclerotic Diseasementioning

confidence: 99%

Triglyceride-Rich Lipoproteins and Plasma Lipid Transport

Havel

2010

ATVB

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Abstract-This memoir provides a history of the triglyceride-rich lipoproteins of blood plasma over the last half-century.As precursors of low-density lipoproteins and in their own right, triglyceride-rich lipoproteins are essential to the formation of atherosclerotic plaques and to consequent ischemic vascular disease. The author recounts research at the National Heart Institute during 1953 to 1956 and continuing thereafter at the University of California San Francisco. Emphasis is placed on key insights arising from investigations of human disease, the interplay of fatty acid and triglyceride-transport involving the liver, small intestine, adipose tissue and muscle, and the role of the liver in the synthesis and catabolism of atherogenic lipoproteins. (Arterioscler Thromb Vasc Biol. 2010;30:9-19.)Key Words: chylomicrons Ⅲ very low-density lipoproteins Ⅲ apolipoproteins Ⅲ lipoprotein receptors Ⅲ atherosclerosis I n 1951, I was one of 8 residents at East Coast medical schools recruited by James Shannon to the National Heart Institute as Clinical Associates to provide care for patients in the Clinical Center of the National Institutes of Health (NIH). At the time, many house officers were being drafted into the U.S. Army for service in Korea. To obviate loss to a "mash" unit, we immediately joined the U.S. Public Health Service. Owing to delays in opening the Clinical Center, I was able to finish my residency at New York Hospital/Cornell Medical Center, arriving in Bethesda in 1953, where by chance I admitted the first inpatient on July 1. In addition to caring for patients our group was expected to engage in research. We were advised to "look around" and select a basic science laboratory to join. During planning for the Clinical Center, Shannon, aware that virtually no NHI scientists were doing "heart" research, asked laboratory heads to suggest appropriate disease-related areas. Christian B. Anfinsen, a protein chemist (and later Nobel laureate for his work on proteinfolding), perused the literature and suggested two topics related to plasma lipids. The first was to investigate the lipemia "clearing factor." At the University of Rochester, Paul Hahn had made a serendipitous observation: in dogs given intravenous heparin, the opalescence of blood plasma occurring postprandially rapidly disappeared. 1 Anfinsen suspected that a protein might be released into the blood by heparin. The second was to investigate the plasma lipoproteins recently described by John Gofman and his students at the University of California Berkeley. They discovered that lipoproteins can be separated from serum by ultracentrifugation and quantified in an analytic ultracentrifuge; and they had reported that a low-density group of these giant macromolecules are risk markers for coronary heart disease. 2 As a result, Anfinsen was asked to organize a new Section in the Laboratory of Metabolism in 1951. Of the 8 who arrived in 1953, Donald Fredrickson, Robert Gordon, and I joined this Section. Research at the National Heart Institute (1953 to 19...

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“…40,41 Interestingly majority of investigators agree that hypertriglyceridemia could be involved in the pathogenesis of hypertensive disorders during pregnancy which is in accordance with our observation. [44][45][46][47][48] We didn't report significant difference in the HDL levels between the PET patients and normotensive pregnant females. Again, present result is in accordance with observations made by earlier investigators.…”

Section: Discussionmentioning

confidence: 99%

“…This high incidence of MeS in severe preeclampsia can be explained by the fact that high triglyceride levels seem to increase the risk of placental vascular disorders, which trigger endothelial dysfunction, atherosclerosis and thrombosis. 44,45,49 with preeclampsia indicates that elevated levels of triglycerides are involved in this disorder. 50 There was no significant difference in age in the PET patients with MeS as compared to PET patients without MeS.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of metabolic syndrome in preeclampsia

Beigh

Naik

Tali

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONPre-eclampsia is defined as new onset of hypertension and proteinuria after 20th weeks of gestation in a previously normotensive woman and it complicates 2-8% of pregnancies and contributes to considerable maternal, neonatal morbidity and mortality.1-3 The majority of maternal deaths during pregnancy are caused by medical disorders and hypertension being the commonest cause. 4 The aetiology of preeclampsia remains unknown despite continued medical research. The pathophysiology of preeclampsia likely involves both maternal and fetal/placental factors although more with the former.The risk of abnormal placentation and preeclampsia is the result of medical conditions associated with vascular ABSTRACT Background: Preeclampsia is associated with increased morbidity and mortality and it increases with severity of preeclampsia. Preeclampsia shares many characteristics of metabolic syndrome (MeS) which has led many investigators to elucidate this relationship. The aim and objective of this study was to assess the prevalence of MS in preeclampsia and its relation with its severity. Methods: The study included 130 cases (41 gestational hypertension (GHTN), 27 mild pre-eclampsia (Mild PET), 47 severe preeclampsia (Severe PET), 13 pre-eclampsia superimposed on chronic hypertension (PSHTN) and 2 eclampsia) based on pre-specified maternal characteristics according to ACOG criteria after 20 th week of gestation. Two hundred normotensive pregnant females served as controls. The frequency of MS was assessed using pregnancy adaptation of MeS definition of the NCEP-ATP III criteria in cases and controls. Results: Metabolic syndrome was found in 37.7% of preeclampsia group and 12% of control group (p<0.00). Among the components of MeS, preeclampsia group was having significantly higher sugars (30% Vs 20%) and body mass index (BMI) (23.8% Vs 7.5%) than controls. GHTN was seen in 31.5%, mild PET in 20.8%, severe PET in 36.2%, PSHTN in 10% and eclampsia in 1.5% of cases. MeS was seen in 57.4% of severe PET, 50% of eclampsia, 26.8% of GHTN, 25.9% of mild PET and 23.1% of PSHTN. The clinical course in preeclampsia with MeS was complicated by IUD (intrauterine death), IUGR (intrauterine growth retardation), preterm delivery, APH and pulmonary edema. Oligohydromnios was less common in preeclampsia with MeS. Conclusions: The frequency of MeS was higher in preeclampsia group as compared to normotensive group. MeS was more significantly higher in patients with severe preeclampsia. In our study there were no demographic, clinical and laboratory predictors of MeS in preeclampsia. On the other hand, preeclampsia patients with MeS had significant maternofoetal complications. There is a need to screen for MeS in pregnant females from the first antenatal visit in order to predict severe preeclampsia.

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The serum lipoprotein transport system in health, metabolic disorders, atherosclerosis and coronary heart disease

Cited by 58 publications

References 35 publications

Serum lipid levels in pregnancies complicated by preeclampsia

Serum lipid levels in pregnancies complicated by preeclampsia

Triglyceride-Rich Lipoproteins and Plasma Lipid Transport

Prevalence of metabolic syndrome in preeclampsia

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