The Serum Levels of Circulating Matrix Metalloproteinase MMP-9, MMP-2/TIMP-2 Complex and TIMP-1 do not Change Significantly During Normal Pregnancy.

Abstract

Objective: Matrix metalloproteinases (MMPs) are important regulators of vascular and uterine remodeling. Normal pregnancy is associated with increased MMP activity. Measurements of the plasma levels on MMPs have not been consistent between studies in complicated pregnancies. We have examined MMP-9, MMP-2 and their respective tissue inhibitors TIMP-1 and TIMP-2 in different time points in the sera of 13 women with normal pregnancy. Results: The serum levels of MMP-9 and TIMP-1 were stable throughout pregnancy. The level of MMP-2/TIMP-2 complex was slightly increased after week 15 without statistical significance. The serum levels of MMP-9, MMP-2/TIMP-2 and TIMP-1 on different time points during normal pregnancy are poorly studied and further measurements of the plasma levels of MMPs and the correlation with MMP levels in the placenta and other maternal tissues are needed.