The serum follicle-stimulating hormone-to-luteinizing hormone ratio at the start of stimulation with gonadotropins after pituitary down-regulation is inversely correlated with a mature oocyte yield and can predict “low responders”

Ho, Jason Yen-Ping; Guu, Hwa-Fen; Yi, Yu-Chiao; Chen, Ming‐Jer; Ho, Esther Shih-Chu

doi:10.1016/j.fertnstert.2004.10.040

Cited by 27 publications

(16 citation statements)

References 25 publications

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“…Using the cut-off value derived from ROC analysis, cycles with an FSH/LH ratio > or =3 produced fewer mature oocytes (8.25 vs. 11.74) and a higher percentage of poor ovarian response cycles (32.5% vs. 14.3%). Additionally, the serum FSH level and FSH/LH ratio at the commencement of gonadotropin stimulation were inversely correlated to the number of mature oocytes [6]. According to our results and previous reports in the literature, the abovementioned combined indexes had excellent performances in evaluating ovarian reserve and response.…”

Section: Discussionsupporting

confidence: 80%

The evaluative effectiveness of a combined index exceeded that of a single variable for the ovarian reserve and response of infertile women

Zhou

Zhao

et al. 2019

Preprint

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Aim of the present study was to explore the evaluative effectiveness of age, ovarian volume, antral follicle count (AFC), serum follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), FSH/LH ratio and ovarian response prediction index (ORPI) to determine which could most advantageously assess ovarian reserve and response.Methods This research enrolled 319 consecutive infertile women who had undergone IVF-ET/ICSI treatments. Abovementioned variables were measured and calculated. Receiver Operating Characteristic Curve analysis was used to analyze the predictive accuracy of variables and to calculate cut-off values and corresponding sensitivity and specificity.Results Our study revealed that the significant variables for evaluating a decline in ovarian reserve include age, total volume of bilateral ovary, FSH, and ORPI. Moreover, the area under the curve (AUC) of ORPI was higher than other three variables (AUC = 0.903), and the cut-off value of ORPI was 0.245 (sensitivity 90.1%, specificity 73.9%). The significant variables forecasting excessive ovarian response were age, AFC, AMH, ORPI, FSH and FSH/LH ratio, and the significant variables forecasting low ovarian response were AMH and FSH/LH ratio. ORPI and FSH/LH ratio presented better effectiveness in evaluating ovarian response. When they were used to predict excessive response, the cut-off values of ORPI and FSH/LH ratio was 0.886 (sensitivity 84.7%, specificity 67.3%) and 1.753 (sensitivity 56.2%, specificity 67.6%), respectively. When used to predict low response, the cut-off value of FSH/LH ratio was 2.983 (sensitivity 75.0%, specificity 83.8%).Conclusions ORPI performed better than did the other variables in evaluating ovarian reserve and predicting excessive ovarian response, and the FSH/LH ratio performed better than did the other variables in predicting low ovarian response. Consequently, we agreed that the evaluative effectiveness of a combined index exceeded that of a single variable for evaluating the ovarian reserve and response of infertile women.

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Section: Discussionsupporting

confidence: 80%

The evaluative effectiveness of a combined index exceeded that of a single variable for the ovarian reserve and response of infertile women

Zhou

Zhao

et al. 2019

Preprint

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“…In another study, lower peak E2 levels on the day of HCG triggering in patients with FSH/LH ratio > 3 was noticed [25]. In our study, E2 level was the same in both groups.…”

Section: Discussionsupporting

confidence: 62%

FSH/LH Ratio as a Predictor of the IVF Outcome in Young Women

Shaeer¹,

Maged²,

Shaheen³

et al. 2018

OJOG

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In Vitro Fertilization (IVF) is the treatment for many causes of infertility. Many studies were done to investigate different factors that can affect the success rate. This study was conducted to evaluate if cycle day 3 (CD3) follicle-stimulating hormone (FSH)/luteinizing hormone (LH) ratio can be a predictor for the IVF outcome in young sub-fertile females ≤ 35 years with normal baseline FSH. This is a retrospective case control study conducted at the Centre of Fertility and Andrology Care (CFAC) in Egypt where 235 sub-fertile women underwent IVF. Patients were grouped based on CD3 FSH/LH ratio. Group A consisted of ≤35-year-old women with FSH/LH ratio < 2 and group B included ≤35-year-old women with FSH/LH ratio ≥ 2. The primary outcomes include the fertilization rate, implantation rate and the clinical pregnancy rate. The secondary outcomes include duration and the total dose of gonadotrophin used. We found that, there was no significant difference in the total dose of gonadotropin used during the IVF cycle. Also, there was no significant difference in the number of retrieved and fertilized oocytes and the number of good embryos. Clinical pregnancy rate was the same in both groups. In conclusion, in patients younger than 35 years, CD3 FSH/LH ratio is not a predictor for IVF outcome.

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“…As similarly, Ho et al [21] assessed the relationship of serum FSH/LH ratio at the start of gonadotropin stimulation after pituitary down-regulation. They found that with an elevated FSH/LH ratio and lower endogenous LH levels, the number of recruited follicles was decreased and the chance of cancelling the cycle was increased.…”

Section: Discussionmentioning

confidence: 99%

Elevated day 3 FSH/LH ratio: a marker to predict IVF outcome in young and older women

Seckin

Türkçapar

Özakşit

2011

J Assist Reprod Genet

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Purpose To evaluate the value of elevated day 3 FSH/LH ratio in predicting IVF results in young and older women. Methods One hundred seventy-four women with normal day 3 FSH levels undergoing IVF treatment were studied. Patients were divided into two groups according to basal FSH/LH ratio: Group 1(FSH/LH ≥3, n043) and Group 2 (FSH/LH <3, n0131). The effects of FSH/LH ratio on IVF outcomes were compared. Also, the impact of elevated FSH/LH levels on younger (<35 years; n0113) and older (≥35 years; n061) women was evaluated. Results Group 1 had significantly lower mean day 3 LH levels (p00.001), lower number of oocytes retrieved (p00.004) and lower clinical pregnancy rate (p00.04). Older women with elevated FSH/LH ratio (n023) had significantly lower transferred good grade embryo counts (p00.04) and lower pregnancy rate (p00.03) versus older women with lower FSH/LH ratio. But in younger women treatment outcomes were similar in both subgroups. Conclusion Elevated day 3 FSH/LH ratio is useful in predicting IVF outcome in older women, but does not seem to be an accurate predictor in younger women.

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The serum follicle-stimulating hormone-to-luteinizing hormone ratio at the start of stimulation with gonadotropins after pituitary down-regulation is inversely correlated with a mature oocyte yield and can predict “low responders”

Cited by 27 publications

References 25 publications

The evaluative effectiveness of a combined index exceeded that of a single variable for the ovarian reserve and response of infertile women

The evaluative effectiveness of a combined index exceeded that of a single variable for the ovarian reserve and response of infertile women

FSH/LH Ratio as a Predictor of the IVF Outcome in Young Women

Elevated day 3 FSH/LH ratio: a marker to predict IVF outcome in young and older women

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