The serum 25(OH)D level and hand grip strength for fall risk assessment among osteoporotic elderly Japanese women

Abstract

Summary We investigated the relationship between serum 25(OH)D levels, grip strength, and fall score in elderly osteoporotic women for fall risk assessment. Both low serum 25(OH)D and low grip strength were independently associated with increased fall risk. The serum 25(OH)D cutoff specific to increased fall risk was 14 mg/dL (35 nmol/L). Purpose This study aimed to establish a cutoff value of serum 25-hydroxyvitamin D (25(OH)D) for fall assessment and investigate the relationship between serum 25(OH)D, grip strength, and fall score adjusted for age in osteoporotic elderly Japanese women. Methods This is a cross-sectional study utilizing collected data of osteoporotic elderly (age ≥65 years) female patients. A questionnaire for fall risk assessment was used, in which a score ≥ 6 was determined as increased fall risk. Serum 25(OH)D levels and grip strength were measured, and the cutoff points were calculated by receiver operating curve (ROC) analysis. Logistic regression analysis with age adjustment was conducted for potential risk factors for fall. Results After applying eligibility criteria, finally, 349 patients were enrolled. The median patient age was 77.0 years, and the mean serum 25(OH)D level was 15.6 ng/mL (36 nmol/L). Based on the ROC analysis, we defined the cutoff values of serum 25(OH)D level and grip strength as 14 ng/mL (35 nmol/L) and 15 kg, respectively. A multivariate analysis adjusted for age was conducted. Low serum 25(OH)D level and grip strength were independent risk factors for ≥6 fall risk scores. Conclusion Both low serum 25(OH)D level and low grip strength were independently associated with increased fall risk score in osteoporotic elderly women. The appropriate serum 25(OH)D cutoff specific to the increased fall risk group in this population was 14 mg/dL (35 nmol/L). These findings might be used for the identification of patients with high fall risks. These results should be confirmed in other patient groups.

Diagnostic Performance of Clinical Laboratory Indicators With Sarcopenia: Results From the West China Health and Aging Trend Study

“…Malnutrition is frequent in the older and there is an evidence that the supplementation of essential amino acid can prevent the older from sarcopenia (16,17). Meanwhile, low 25(OH)VD levels have been confirmed to lead to loss of muscle mass and grip strength through the reduction in II type muscle fiber synthesis identified as fast twitch, which was also consistent with our findings (18,19). Several studies have already showed that 25(OH)VD could induce muscle cells proliferation, differentiation, and regulate muscle regeneration initiation (20,21).…”

Effect of Preoperative Oral Carbohydrates on Insulin Resistance in Older Adults Who Underwent Total Hip or Knee Arthroplasty: A Prospective Randomized Trial

“…38 Hand grip strength is strongly associated with overall muscle strength and is a valuable indicator of well-being, functional status, and frailty and can be a predictor of falls and postsurgical complications in older adults. 38,39 The pathophysiology of frailty is related to insulin resistance. 40 Therefore, the frailty of participants in the two groups was compared using hand grip strength but no difference was observed.…”

Relationship between sacral‐abdominal wall distance and grip strength in postmenopausal osteoporotic patients

“…To assess the fall risk, a fall score was used, with five data items based on activities of daily living. 31 Scores for each item were calculated based on odds ratios; those with a score of 6 points or more were considered at high risk for falls 20,31 : (1) have fallen in the past year, (2) think their walking speed has slowed down recently, (3) use a cane, (4) think their back has rounded recently, (5) take 5 or more medications; the score for each item was calculated based on odds ratio. Each item was scored differently; if the participant answered Yes, 5 points were allocated to the first question and 2 points each were allocated for questions 2-5.…”