The serous membranes in the cat. Electron microscopic observations

Michailova, K.

doi:10.1016/s0940-9602(96)80129-4

Cited by 16 publications

(25 citation statements)

References 29 publications

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“…the mesothelium, resting on basal lamina underlined by a submesothelial layer of connective tissue [2]. However, several detailed ultrastructural studies on both, visceral and parietal, pericardial leaflets have indicated that the reality is more complex [3][4][5][6][7]. The most striking element of this complexity is the presence of (at least) two distinct mesothelial cell forms, the flat one and the cuboidal one.…”

Section: The Ultrastructure Of the Pericardiummentioning

confidence: 99%

“…The signs of some endo/ /exo-cytotic or trans-cytotic activity are visible as vesicle formation at both the apical and basal cell membranes. The apical membrane is covered by short and www.fhc.viamedica.pl scant microvilli [3][4][5][6][7]. In contrast, the cuboidal cells are rich in organelles, with numerous mitochondria, very well elaborated rough endoplasmic reticulum and abundant Golgi stacks [3][4][5][6][7] (Figure 1).…”

Section: The Ultrastructure Of the Pericardiummentioning

confidence: 99%

“…The apical membrane is covered by short and www.fhc.viamedica.pl scant microvilli [3][4][5][6][7]. In contrast, the cuboidal cells are rich in organelles, with numerous mitochondria, very well elaborated rough endoplasmic reticulum and abundant Golgi stacks [3][4][5][6][7] (Figure 1). There are numerous vesicles, vacuoles and multivesicular bodies, as well as the signs of the robust vesicle formation at the cell membranes in the form of either coated or uncoated vesicles being in the process of internalization from or budding of the cell membranes ( Figure 1).…”

Section: The Ultrastructure Of the Pericardiummentioning

confidence: 99%

“…The apical surface of cuboidal cells is covered by abundant microvilli, having the length of up to 3 μm [3][4][5][6][7]; some of the microvilli bifurcate near their ends. Both cell types occasional bear primary cilia, and are covered by a thick layer of glycocalyx [3][4][5].…”

Section: The Ultrastructure Of the Pericardiummentioning

confidence: 99%

“…Junctional complexes between adjacent mesothelial cells (both flat and cuboidal) consist of desmosomes, which reinforce intercellular adhesion and www.fhc.viamedica.pl tight junctions, which form permeability barriers [3][4][5][6][7]. Accordingly, the pericardial layers are impermeable to the particles of the size ranging from 10 to 30 nm; however, they do allow for passing the particles that are smaller than 6 nm, such as horseradish peroxidase molecules [9].…”

Section: The Ultrastructure Of the Pericardiummentioning

confidence: 99%

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Pericardium: structure and function in health and disease

Jaworska-Wilczyńska

Trzaskoma

Szczepankiewicz

et al. 2016

Folia Histochem Cytobiol.

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Normal pericardium consists of an outer sac called fibrous pericardium and an inner one called serous pericardium. The two layers of serous pericardium: visceral and parietal are separated by the pericardial cavity, which contains 20 to 60 mL of the plasma ultrafiltrate. The pericardium acts as mechanical protection for the heart and big vessels, and a lubrication to reduce friction between the heart and the surrounding structures. A very important role in all aspects of pericardial functions is played by mesothelial cells. The mesothelial cells form a monolayer lining the serosal cavity and play an important role in antigen presentation, inflammation and tissue repair, coagulation and fibrinolysis. The two major types of mesothelial cells, flat or cuboid, differ substantially in their ultrastructure and, probably, functions. The latter display abundant microvilli, RER, Golgi dense bodies, membrane-bound vesicles and intracellular vacuoles containing electron-dense material described as dense bodies. The normal structure and functions of the pericardium determine correct healing after its injury as a result of surgery or microbial infection. The unfavorable resolution of acute or chronic pericarditis leads to the formation of adhesions between pericardial leaflets which may lead to serious complications.

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Section: The Ultrastructure Of the Pericardiummentioning

confidence: 99%

Section: The Ultrastructure Of the Pericardiummentioning

confidence: 99%

Section: The Ultrastructure Of the Pericardiummentioning

confidence: 99%

Section: The Ultrastructure Of the Pericardiummentioning

confidence: 99%

Section: The Ultrastructure Of the Pericardiummentioning

confidence: 99%

See 3 more Smart Citations

Pericardium: structure and function in health and disease

Jaworska-Wilczyńska

Trzaskoma

Szczepankiewicz

et al. 2016

Folia Histochem Cytobiol.

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Mesothelial lamellar bodies in norm and experimental conditions. Transmission and scanning electron microscopic observations on the peritoneum, pleura and pericardium

Michailova

2004

Anat Embryol

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The ultrastructural characteristics of the mesothelial intracellular and extracellular lamellar bodies (LB) in norm, and especially in pathological conditions are still unknown. After routine fixation procedure, material from organs in the three serous cavities of Wistar rats, as control group were compared with animals following experimental hemothorax (EH) and experimental peritonitis (EP), using transmission and scanning electron microscopy (TEM, SEM). Different membrane-bound profiles, short strip-like structures and single LB characterize the control group. Five days after EH small groups of LB were observed. Single balloon-like profiles, numerous particles and larger groups of LB with wide varieties in size, form and membrane structure characterize the 8th day after EH. Thin and concentric membranes build single LB the 5th day of EP. Eight days after the same treatment, groups of LB, complex structures with several multilamellar centers, strip-like structures with rough granulo-filamentous material and uninterrupted covering over wide areas were observed. We conclude that constant components in the untreated rats are different membrane profiles, as initial lamellar formations and single typical LB with predominant intracellular position. The preferable sites for exocytosis of LB are the intercellular spaces. The present data demonstrate simultaneous findings of the two main groups of formations by using routine fixation in the control group and in the treated animals. The first represent LB as well as other round profiles, observed by TEM and particles, observed by SEM, which are widespread and probably have a basic role. The second ones are strip-like structures and its SEM-equivalents, i.e. uninterrupted covering. TEM-profiles and their SEM-images show significant organ differences and in some cases lack of correspondence between both electron microscopic techniques in the same treatment. Significant enlargement of the number of LB and the length of the strip-like structures characterize the mesothelium after pathologic conditions. LB with considerable differences in the structure and larger particles over the microvillous border predominate after EH. Strip-like profiles, continuous covering and smaller groups of LB with similar morphology and preferable submesothelial position characterize the mesothelium after EP.

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Mesothelial primary cilia of peritoneal and other serosal surfaces

Bird

2004

Cell Biology International

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The conspicuous presence of primary cilia, a small immotile cilium present on most cell types, left researchers with little doubt of their functional relevance. Recently mechanosensitive functional significance was established and a link with the pathogenesis of polycystic kidney disease. Together these discoveries have raised the profile of this, previously considered "vestigial", organelle. Primary cilia are expressed on the apical surface of serosal mesothelium and display regional variation but are more abundant on biosynthetically active cells. Adult mesothelial cells are highly biosynthetic producing a phospholipid rich surfactant that lubricates and protects the visceral organs. The mesothelium is utilized as a semipermeable membrane during peritoneal dialysis for patients with end stage renal failure. However, little is known about the functional role of primary cilia on this highly specialized cell type. The present review, examines the significance of the primary cilium in serosal mesothelial cell biology with an emphasis on ciliary location, structure, form and function. Future research is identified and discussed in view of the emerging role cilia have in other cells and the established function of the serosal mesothelium in development, normal function, peritoneal dialysis and pathology of the serosal membranes.

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The serous membranes in the cat. Electron microscopic observations

Cited by 16 publications

References 29 publications

Pericardium: structure and function in health and disease

Pericardium: structure and function in health and disease

Mesothelial lamellar bodies in norm and experimental conditions. Transmission and scanning electron microscopic observations on the peritoneum, pleura and pericardium

Mesothelial primary cilia of peritoneal and other serosal surfaces

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