The Serotonin Transporter Plays an Important Role in Male Sexual Behavior: A Study in Serotonin Transporter Knockout Rats

Chan, Johnny S.W.; Snoeren, Eelke M.S.; Cuppen, Edwin; Waldinger, Marcel D.; Olivier, Berend; Oosting, Ronald S.

doi:10.1111/j.1743-6109.2010.01961.x

Cited by 57 publications

(70 citation statements)

References 60 publications

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“…This observation is in line with the finding that 5-HTT −/− mice displayed increased anxiety in the EPM and light/dark box only when exposed to predator odor (Adamec et al 2006). Finally, while prenatal fluoxetine did not alter sexual behavior, it was reduced in 5-HTT −/− rats, but only after extensive training (Chan et al 2010). The comparisons between the effects of pharmacological 5-HTT blockade and of lifetime 5-HTT absence suggest that 5-HT-induced neurodevelopmental changes, rather than lifetime effects, explain the observed phenotypes in 5-HTT −/− rodents.…”

Section: Discussionmentioning

confidence: 79%

Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring

et al. 2011

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Section: Discussionmentioning

confidence: 79%

Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring

et al. 2011

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“…This falls under the umbrella 'normal IELT and no control'. Classification of PE is still evolving as different classification models offer different clinical and research benefits [Cahangirov et al 2011;Chan et al 2011;Clément et al 2009;Waldinger and Olivier, 2005;Pattij et al 1995].…”

Section: Definition Of Premature Ejaculationmentioning

confidence: 99%

Medical therapy for premature ejaculation

Mohee

Eardley

2011

Therapeutic Advances in Urology

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Premature ejaculation (PE) is a common male sexual dysfunction. Advances in PE research have been hampered owing to a nonstandardized definition of PE, until the definition by the International Society of Sexual Medicine (ISSM) in 2009. Once the diagnosis of PE is established through a thorough history, a variety of medical therapies is available, including tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), centrally acting opiates, phosphodiesterase 5 inhibitors and topical desensitizing creams. Most of these treatments increase the intravaginal ejaculation latency time (IELT) and patient satisfaction scores, with the most convincing evidence for SSRIs and topical creams. Daily SSRIs such as paroxetine, although efficacious, do have a substantial and prolonged side effect profile. Dapoxetine, which is a on-demand SSRI, is the only licensed drug for the treatment of PE, increasing IELT by a factor of 2.5 to 3 with limited and tolerable side effects. In the near future, the topical aerosol PSD502 is due to be licensed for the treatment of PE, increasing IELT by up to a factor of 6 but having minimal local and negligible systemic side effects.

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“…Both human and animal studies showed that serotonin plays an important role in sexual and particularly ejaculatory activity Waldinger, 2005;de Jong et al, 2006;Olivier et al, 2006;Chan et al, 2011). In some cases, a biologic variation in the IELT in men may be because of different regulation of the serotonergic receptor subtypes and/or to other genetic factors.…”

Section: Serotonin (5-ht)mentioning

confidence: 99%

The characterization, current medications, and promising therapeutics targets for premature ejaculation

Gür

Sikka

2015

Andrology

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SUMMARYPremature ejaculation (PE) is the most prevalent male sexual dysfunction. This is associated with negative personal and interpersonal psychological outcomes. The pharmacologic treatment of PE includes the use of antidepressants, local anesthetic agents, and phosphodiesterase type 5 inhibitors. While numerous treatments can control PE, only antidepressants and topical anesthetic creams and sprays have recently been shown to be more effective. This review focuses on the physiology and pharmacology of ejaculation, the pathophysiology of PE and the most effective pharmacological treatment of PE. Pharmacotherapy of PE with off-label shortacting selective serotonin reuptake inhibitors (SSRIs) is common, effective, and safe. Dapoxetine, a SSRI with a short half-life, has been recently evaluated for the treatment of PE by several countries and results are promising. In clinical practice, follow-up side effects are an important part of the management strategy for PE. The understanding of etiology, pathophysiology, and treatment modalities of PE would be beneficial to clinician in helping patients with this disappointing sexual problem.

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The Serotonin Transporter Plays an Important Role in Male Sexual Behavior: A Study in Serotonin Transporter Knockout Rats

Cited by 57 publications

References 60 publications

Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring

Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring

Medical therapy for premature ejaculation

The characterization, current medications, and promising therapeutics targets for premature ejaculation

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