The serotonin transporter gene and startle response during nicotine deprivation

Minnix, Jennifer A.; Robinson, Jason D.; Lam, Cho Y.; Carter, Brian L.; Foreman, Jennifer E.; Vandenbergh, David J.; Tomlinson, Gail E.; Wetter, David W.; Cinciripini, Paul M.

doi:10.1016/j.biopsycho.2010.09.013

Cited by 5 publications

(2 citation statements)

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“… References: a (Nikolov et al 2011); b (Stallings et al 2005; Stallings et al 2003); c (Nelson et al 2014; Nelson et al 2013); d (Maher et al 2011); e (Carter et al 2008; Cinciripini et al 2006; Cinciripini et al 2005; Lam et al 2012; Minnix et al 2011; Robinson et al 2007; Robinson et al 2011); f (Edenberg 2002; Edenberg et al 2010); g (Saccone et al 2009a; Saccone et al 2009b); h (Aromaa and Koskinen 2004; Rouvinen-Lagerstrom et al 2013); i (Bierut et al 2010; Bierut et al 2008); j (Broms et al 2012; Kaprio et al 2002); k (Kamens et al 2013); l (Frank et al 2012; Treutlein et al 2009); m (Levran et al 2008); n (Iacono et al 1999; Keyes et al 2009; McGue et al 2007; Miller et al 2012); o (Loukola et al 2008; Saccone et al 2007); p (Loukola et al 2008); q (Elliott et al 1985; Elliott et al 1989; Hoft et al 2009); r (Andrews et al 2003); s (Van den Oord et al 2006); t (David et al 2011); u (Nikolov et al 2011); v (Hops et al 2000); w (Weiss et al 2008); x (Chen et al 2009; Kendler et al 2007; …”

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confidence: 99%

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Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts

et al. 2015

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The mu1 opioid receptor gene, OPRM1, has long been a high-priority candidate for human genetic studies of addiction. Because of its potential functional significance, the non-synonymous variant rs1799971 (A118G, Asn40Asp) in OPRM1 has been extensively studied, yet its role in addiction has remained unclear, with conflicting association findings. To resolve the question of what effect, if any, rs1799971 has on substance dependence risk, we conducted collaborative meta-analyses of 25 datasets with over 28,000 European-ancestry subjects. We investigated non-specific risk for “general” substance dependence, comparing cases dependent on any substance to controls who were non-dependent on all assessed substances. We also examined five specific substance dependence diagnoses: DSM-IV alcohol, opioid, cannabis, and cocaine dependence, and nicotine dependence defined by the proxy of heavy/light smoking (cigarettes-per-day > 20 versus ≤ 10). The G allele showed a modest protective effect on general substance dependence (OR = 0.90, 95% C.I. [0.83–0.97], p-value = 0.0095, N = 16,908). We observed similar effects for each individual substance, although these were not statistically significant, likely because of reduced sample sizes. We conclude that rs1799971 contributes to mechanisms of addiction liability that are shared across different addictive substances. This project highlights the benefits of examining addictive behaviors collectively and the power of collaborative data sharing and meta-analyses.

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Section: Figurementioning

confidence: 99%

“… e (Carter et al 2008; Cinciripini et al 2006; Cinciripini et al 2005; Lam et al 2012; Minnix et al 2011; Robinson et al 2007; Robinson et al 2011); …”

Section: Figurementioning

confidence: 99%

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts

et al. 2015

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Startle Reflex and Psychophysiology

Meehan¹,

Miranda²

2013

The Wiley‐Blackwell Handbook of Addiction Psychopharmacology

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The Trilogy of GxE : Conceptualization, Operationalization, and Application

Grigorenko

Bick

Campbell

et al. 2016

Developmental Psychopathology

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This chapter is aimed at summarizing and discussing selected aspects of the literatures on the interactions between genes and environments (GxE). Although it is designed to be informative for researchers and practitioners interested in the field of developmental psychopathology, it reviews not only psychological but other related (epidemiological, genetic, and psychiatric) literatures. The chapter is structured to cover the conceptualization, operationalization, and application of the concept of GxE. In doing so, it presents the history of the concept, illustrates the ways it is put into practice today, and illuminates numerous complexities related to its applications. Although predominantly a literature review, the chapter presents two simulation studies and two illustrations of current and potential types of studies exercised in the field. Whereas not conceived as a practical set of guidelines for GxE studies, the chapter offers a number of recommendations that might be instrumental to researchers who are interested in conducting or interpreting GxE studies.

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The serotonin transporter gene and startle response during nicotine deprivation

Cited by 5 publications

References 77 publications

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts

Startle Reflex and Psychophysiology

The Trilogy of GxE : Conceptualization, Operationalization, and Application

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