The serotonin precursor 5-hydroxytryptophan elevates serum leptin levels in mice

Yamada, Jun; Sugimoto, Yukihiko; Ujikawa, Masanori

doi:10.1016/s0014-2999(99)00580-4

Cited by 34 publications

(27 citation statements)

References 12 publications

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“…In previous reports, we showed that 5-HTP elevated serum leptin levels in non-fasted mice. 15,16) Thus, it indicates that 5-HTP can increase leptin secretion in both fasted and non-fasted mice. Serum leptin levels after administration of 5-HTP are similar to those after milk intake in mice.…”

Section: Discussionmentioning

confidence: 99%

“…15,16) We examined the mechanism of leptin secretion induced by 5-HTP. We found that hyperleptinemia induced by 5-HTP was caused by formation of 5-HT in the periphery.…”

Section: Discussionmentioning

confidence: 99%

“…10,13,14) We previously demonstrated that systemic injection of a 5-HT precursor, 5-HTP, increases serum leptin levels in mice. 15,16) We further reported that hyperleptinemia elicited by 5-HTP is mediated by insulin but not corticosterone. 17) Since both 5-HTP and leptin cause hypophagia, it is suggested that 5-HTP-induced anorexia may be related to its leptin-releasing effects.…”

mentioning

confidence: 81%

“…15) Mice were decapitated and blood was collected in plastic tubes. Serum leptin levels were measured using a commercially available ELISA kit (Morinaga mouse leptin kit, Japan).…”

Section: Animalsmentioning

confidence: 99%

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Involvement of Leptin in Hypophagia Induced by the Serotonin Precursor 5-Hydroxytryptophan (5-HTP) in Mice

Yamada

Sugimoto

Ujikawa

2006

Biological & Pharmaceutical Bulletin

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We previously demonstrated that a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice. It was reported that administration of 5-HTP elicits hypophagia in rodents and humans. In the present study, we examined involvement of leptin in 5-HTP-elicited decreases in the milk intake of fasted mice. Serum leptin levels increased with increases in milk intake in mice, while 5-HTP strongly decreased milk intake in fasted mice compared to that in the control group. Serum leptin levels in fasted mice treated with 5-HTP were similar to those control mice after milk intake. As leptin is a powerful anorectic signal, 5-HTP-induced anorexia may be mediated by facilitation of leptin secretion.

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Section: Discussionmentioning

confidence: 99%

“…15,16) We examined the mechanism of leptin secretion induced by 5-HTP. We found that hyperleptinemia induced by 5-HTP was caused by formation of 5-HT in the periphery.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 81%

“…15) Mice were decapitated and blood was collected in plastic tubes. Serum leptin levels were measured using a commercially available ELISA kit (Morinaga mouse leptin kit, Japan).…”

Section: Animalsmentioning

confidence: 99%

See 2 more Smart Citations

Involvement of Leptin in Hypophagia Induced by the Serotonin Precursor 5-Hydroxytryptophan (5-HTP) in Mice

Yamada

Sugimoto

Ujikawa

2006

Biological & Pharmaceutical Bulletin

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“…[27][28][29] Moreover, it has been shown that 5-HTP increases plasma concentration of leptin, the hormone synthesized from fat that inhibits the feeling of hunger in the hypothalamus. [30][31][32][33] Currently, 5-HTP is available exclusively in oral or parenteral formulations. In some cases, however, the oral route might not be the best choice for the patient, because of difficulties with swallowing, or when a faster onset of action is required.…”

Section: Introductionmentioning

confidence: 99%

Satiety and amino-acid profile in overweight women after a new treatment using a natural plant extract sublingual spray formulation

et al. 2009

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Objective: To test the effect on satiety of a formulation comprising plant extracts naturally containing 5-hydroxytryptophan, delivered as sublingual spray (5HTP-Nat Exts), administered five times a day for 2 months. Design: Two-month, randomized, double-blind, placebo-controlled trial. Subjects: A total of 27 healthy, adult overweight women were randomly assigned to the treatment (14) or the placebo group (13). Measurements: Visual analog scales were used to assess appetite sensations every day. Moreover, the study evaluated the bioavailability of 5-hydroxytryptophan following sublingual delivery over 8 weeks, by comparing 24-h urinary excretion of 5-hydroxy-3-indoleacetic acid (5-HIAA), determined at baseline and after 2 months. Other secondary end points of the study were to compare body composition, depressive symptoms, severity of binge eating and quality of life. Finally, the study tested whether a single administration of 5HTP-Nat Exts in fasting state has an effect on amino-acid profile and on appetite ratings and whether 5HTP-Nat Exts administered before a fixed test meal has any effect on satiety. Results: The group using the 5HTP-Nat Exts experienced a significantly greater increase in their sensation of satiety over an 8-week timeframe and in fasting state following administration of 5HTP-Nat Exts than the placebo group did (AUC ¼ 305.2 (52.8) vs 236.6 (59.4), mean difference À68.7 (95% confidence interval (CI) À116.2 to À21.2), P ¼ 0.007; mean difference in Haber score change 2.5 (95% CI 0.62-3.12, P ¼ 0.007)). A difference was observed between the groups for the mean change in 5-HIAA. All the amino acids evaluated after a single administration of 5HTP-Nat Exts were found to be similar. Differences were found for the mean change in body mass index, skinfold thicknesses and hip circumference. The other parameters were found to be similar. Conclusion: All these findings suggest that 5HTP-Nat Exts may be safely used to treat the problem of appetite control in overweight women during a weight loss program.

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Long‐term fluoxetine administration does not result in major changes in bone architecture and strength in growing rats

Westbroek

Waarsing

Leeuwen

et al. 2006

J of Cellular Biochemistry

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Many studies have indicated that serotonin and its transporter play a role in bone metabolism. In this study we investigated the effect of selective serotonin re-uptake inhibitor (SSRI), fluoxetine (Prozac) on bone architecture and quality in growing female rats. We therefore administrated rats with clinically relevant doses of fluoxetine for a period of 6 months. DXA scans were performed during the treatment period in order to follow parameters as body weight, fat percentage and BMD. After 6 months of treatment, femurs were used to analyze bone architecture and bone strength, by means of microCT scans and three-point bending assays, respectively. We found a slightly diminished bone quality, reflected in a lower bone tissue strength, which was compensated by changes in bone geometry. As leptin and adiponectin could be possible factors in the serotonergic regulation of bone metabolism, we also determined the levels of these factors in plasma samples of all animals. Leptin and adiponectin levels were not different between the control group and fluoxetine-treated group, indicating that these factors were not involved in the observed changes in bone geometry and quality.

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The serotonin precursor 5-hydroxytryptophan elevates serum leptin levels in mice

Cited by 34 publications

References 12 publications

Involvement of Leptin in Hypophagia Induced by the Serotonin Precursor 5-Hydroxytryptophan (5-HTP) in Mice

Involvement of Leptin in Hypophagia Induced by the Serotonin Precursor 5-Hydroxytryptophan (5-HTP) in Mice

Satiety and amino-acid profile in overweight women after a new treatment using a natural plant extract sublingual spray formulation

Long‐term fluoxetine administration does not result in major changes in bone architecture and strength in growing rats

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