The Serotonin-1A Receptor in Anxiety Disorders

Akimova, Elena; Lanzenberger, Rupert; Kasper, Siegfried

doi:10.1016/j.biopsych.2009.03.012

Cited by 293 publications

(196 citation statements)

References 79 publications

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“…The role of catecholamines, in particular of noradrenaline, is less clear. Substantial evidence supports the hypothesis of a disturbed noradrenergic neurotransmission (adrenergic receptors a1, a2, b1, b2) contributing to anxiety symptoms [21][22][23][24]. Previous studies highlighted increase noradrenaline release, receptors dysregulation or dysregulation of the brain noradrenergic system in patients with anxiety disease [8,9].…”

Section: Discussionmentioning

confidence: 66%

Anxiety trait in patients with stress-induced cardiomyopathy: a case–control study

et al. 2011

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Background Stress-induced Tako-tsubo cardiomyopathy (TTC) is an acute cardiac syndrome, mimics ST elevation myocardial infarction (STEMI), largely confined to postmenopausal women, frequently precipitated by a stressful event. The pathogenesis of TTC is still unknown. Some authors hypothesized a possible connection between TTC and anxiety disease, but no previous study analyzed the relationship between anxiety trait and TTC. This study sought to assess the potential role of anxiety trait in the development and clinical course of TTC. Methods We included in the present prospective casecontrol study 50 consecutive patients admitted to our Hospital with a diagnosis of TTC according to the Mayo Clinic criteria. Fifty control patients with anterior STEMI matched for clinical characteristics such as age, gender, and hypertension were selected. During the hospitalization, all patients were asked to complete the Spielberger Trait Anxiety Inventory (STAI) scale for measuring self-reported trait anxiety (Trait-A). Outcome measures at follow-up were death, TTC recurrence, and rehospitalization. Results The mean value of STAI scale was 46 ± 12 in TTC patients and 45 ± 14 in STEMI patients (p = 0.815). High-anxiety trait (STAI scale value C 40) was documented in 30 (60%) TTC patients and in 26 (52%) STEMI patients (p = 0.387). At multivariate analysis, predictors of TTC were lower peak creatine kinase value (HR 0.999; 95% CI 0.998-0.999; p = 0.018) and an antecedent stressful trigger event (HR 45.487;; p = 0.001), but anxiety trait was not. There were no differences in outcome measures between TTC patients with or without high-anxiety trait. Conclusion In TTC patients, high-anxiety trait is a common finding but it is not significantly more frequent than in patients with STEMI. Moreover, a high-anxiety trait seems to be neither associated with a worse clinical outcome nor a predictor of TTC. Our study do not support the routine evaluation of anxiety trait in patients with TTC.

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Section: Discussionmentioning

confidence: 66%

Anxiety trait in patients with stress-induced cardiomyopathy: a case–control study

et al. 2011

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“…In particular, the inhibitory serotonergic receptor, serotonin receptor 1A (5-HT1A), is widely expressed in the mammalian brain and has a major role in modulating traits related to these disorders (Akimova et al, 2009;Albert and Lemonde, 2004;Savitz et al, 2009). Within the raphe, 5-HT1A acts as a presynaptic autoreceptor whose activation leads to reduced firing of serotonergic neurons and decreased serotonin levels in a variety of forebrain projection structures.…”

Section: Introductionmentioning

confidence: 99%

Developmental Effects of Serotonin 1A Autoreceptors on Anxiety and Social Behavior

Donaldson

Piel

Santos

et al. 2013

Neuropsychopharmacol

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The serotonin 1A receptor (5-HT1A) has a major role in modulating the effects of serotonin on mood and behavior. Previous studies have shown that knockout of 5-HT1A selectively in the raphe leads to higher levels of anxiety during adulthood. However, it remains unclear whether this phenotype is due to variation in receptor levels specifically during development or throughout life. To test the hypothesis that developmental sensitivity may underlie the effects of 5-HT1A on anxiety, we used an inducible transgenic system to selectively suppress 5-HT1A levels in serotonergic raphe neurons from post-natal days (P) 14 to P30, with a maximal reduction of 40% at P21 and return to regular levels by P30. This developmental decrease in receptor levels has long-lasting consequences, increasing anxiety and decreasing social investigation in adulthood. In addition, post-natal knockdown of autoreceptors leads to long-term increases in the excitability of serotonergic neurons, which may represent a mechanism underlying the effects of post-natal receptor variation on behavior later in life. Finally, we also examined the interplay between receptor variation and juvenile exposure to stress (applied from P14 to P21). Similar to receptor knockdown, juvenile exposure to stress led to increased anxiety phenotypes but did not exacerbate 5-HT1A knockdown-mediated anxiety levels. This work indicates that the effects of 5-HT1A autoreceptors on anxiety and social behaviors are developmentally mediated and suggests that natural variations in the expression of 5-HT1A may act during development to influence individual anxiety levels and contribute to susceptibility to anxiety disorders.

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“…In particular, the main inhibitory serotonin receptor (5-HT 1A ) seems to play a key role in major depression (Drevets et al, 2000;Hirvonen et al, 2008) and anxiety disorders (Gordon and Hen, 2004;Akimova et al, 2009). Animal studies further underline the involvement of the 5-HT 1A receptor in anxiety-like behavior (Gross et al, 2002;Ö gren et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Escitalopram Enhances the Association of Serotonin-1A Autoreceptors to Heteroreceptors in Anxiety Disorders

Hahn¹,

Lanzenberger²,

Wadsak³

et al. 2010

J. Neurosci.

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The Serotonin-1A Receptor in Anxiety Disorders

Cited by 293 publications

References 79 publications

Anxiety trait in patients with stress-induced cardiomyopathy: a case–control study

Anxiety trait in patients with stress-induced cardiomyopathy: a case–control study

Developmental Effects of Serotonin 1A Autoreceptors on Anxiety and Social Behavior

Escitalopram Enhances the Association of Serotonin-1A Autoreceptors to Heteroreceptors in Anxiety Disorders

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