The seroprevalence of SARS-CoV-2 antibodies among health care workers before the era of vaccination: a systematic review and meta-analysis

Kayı, İlker; Madran, Bahar; Keske, Şiran; Karanfil, Özge; Arribas, José Ramón; Psheniсhnaya, Natalia; Petrosillo, Nicola; Gönen, Mehmet; Ergönül, Önder

doi:10.1016/j.cmi.2021.05.036

Cited by 49 publications

(64 citation statements)

References 49 publications

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“…Our main study finding was that the most important risk factor for SARS-CoV-2 infection in HCWs in the early phase of the outbreak was suspected exposure to COVID-19 cases outside the hospital, similar to other studies (23,24). Among HCWs admitted to the COVID-19 outpatient clinic, 61% had suspected exposure inside or outside the hospital, of whom 16% got infected with COVID-19, which is a higher percentage than those reported in other studies (25).…”

Section: Discussionsupporting

confidence: 88%

Predictors of COVID-19 among Healthcare Workers who were Exposed to COVID-19

Erol¹,

Yalçın²,

Sarı³

et al. 2021

Infect Dis Clin Microbiol

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Background:We described the outcomes of healthcare workers (HCWs) who have been exposed to COVID-19. Materials and Methods:We included the HCWs exposed COVID-19 and admitted to the COVID-19 outpatient clinic between March 13 and August 31, 2020, at a university hospital in Ankara, Turkey. The clinical data and exposure status were retrospectively obtained from medical records. Results:We analyzed 809 admissions of 690 HCWs. In total, 490 HCWs were admitted after suspected exposure to COVID-19 patients. In 32% of these admissions, typical symptoms were observed, and 15% of them developed COVID-19. Polymerase chain reaction test for SARS-CoV-2 was positive in %10 of asymptomatic HCWs. Exposure outside the hospital was 2.3 times more common (OR 2.28, p=0.020, CI 1.141-4.543) than exposure in the hospital. In the hospital setting, exposure to a patient was 1.6 times higher than social contact with colleagues during work. Male gender and occupations other than doctors were independent risk factors. Among HCWs diagnosed with COVID-19, 13% required hospitalization; fortunately, there were no intensive care unit admissions and no deaths. Conclusion:After suspected exposure, HCWs should be screened for SARS-CoV-2 and monitored closely for symptom development. Strict infection control precautions and appropriate personal protective equipment use are crucial to reducing transmission of SARS-CoV-2 both in the hospital setting and in social life.

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Section: Discussionsupporting

confidence: 88%

Predictors of COVID-19 among Healthcare Workers who were Exposed to COVID-19

Erol¹,

Yalçın²,

Sarı³

et al. 2021

Infect Dis Clin Microbiol

View full text Add to dashboard Cite

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“…A recent meta-analysis has reported that seroprevalence levels were higher among male HCWs. 11 Another systematic review observed higher seroprevalence ratios among men. 28 This association may be correlated with the fact that men tend to show less adherence to protective protocols compared with women.…”

Section: Discussionmentioning

confidence: 99%

“… 3–10 It was indicated that HCWs who are male and from ethnic minorities resulted in higher seroprevalence level. 11 …”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of the SARS-CoV-2 antibody in healthcare workers: a multicentre cross-sectional study in 10 Colombian cities

et al. 2021

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BackgroundHealthcare workers are at increased risk of infection due to occupational exposure to SARS-CoV-2-infected patients. The objective of this study was to determine the seroprevalence of SARS-CoV-2 in healthcare workers in Colombia.MethodsThis study is a cross-sectional study focused on estimating the seroprevalence of SARS-CoV-2 antibodies in healthcare workers from 65 hospitals in 10 cities in Colombia during the second semester of 2020. The seroprevalence was determined using an automated immunoassay (Abbott SARS-CoV-2 CLIA IgG). The study included a survey to establish the sociodemographic variables and the risk of infection. A multivariate model was used to evaluate the association between the results of seroprevalence and risk factors.ResultsThe global seroprevalence of antibodies against SARS-CoV-2 was 35% (95% Bayesian CI 33% to 37%). All the personnel reported the use of protective equipment. General services personnel and nurses presented the highest ratios of seroprevalence among the healthcare workers. Low socioeconomic strata have shown a strong association with seropositivity.ConclusionThis study estimates the prevalence of SARS-CoV-2 infection among healthcare workers. Even though all the personnel reported the use of protective equipment, the seroprevalence in the general services personnel and nurses was high. Also, a significant difference by cities was observed.

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“…6 Recent meta-analysis reported 8% SARS-CoV-2 seroprevalence in healthcare workers before vaccine initiation. 7 An early study on the development of SARS-CoV-2 antibodies in symptomatic patients with COVID-19 reported that IgM had the highest value during 20-22 days after onset while IgG had the highest value during 17-19 days after onset. 8 More complete information on immunoglobulin development was reported in a recent systematic review that IgM had median seroconversion time between four to 14 days, reached its peak at 2-5 weeks, then declined to an undetectable level at 6 weeks postonset while IgG had median seroconversion time between 12 and 15 days, reached its peak at 3-7 weeks, then diminished after 8 weeks after onset.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“… 6 Recent meta-analysis reported 8% SARS-CoV-2 seroprevalence in healthcare workers before vaccine initiation. 7 …”

Section: Introductionmentioning

confidence: 99%

COVID-19 seroprevalence among hospital staff and preprocedural patients in Thai community hospitals: a cross-sectional study

et al. 2021

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ObjectivesWe aimed to explore the seroprevalence of hospital staff comparing to preprocedural patients in Thai community hospitals to shed light on the situation of COVID-19 infection of frontline healthcare workers in low infection rate countries where mass screening was not readily available.DesignCross-sectional study.Setting52 community hospitals in 35 provinces covered all regions of Thailand.Participants857 participants consisted of 675 hospital staff and 182 preprocedural patients.Outcome measureCOVID-19 seroprevalence using a locally developed rapid IgM/IgG test kitResultsOverall, 5.5% of the participants (47 of 857) had positive IgM, 0.2% (2 of 857) had positive IgG which both of them also had positive IgM. Hospitals located in the central part of Thailand had the highest IgM seroprevalence (11.9%). Preprocedural patients had a higher rate of positive IgM than the hospital staff (12.1% vs 3.7%). Participants with present upper respiratory tract symptoms had a higher rate of positive IgM than those without (9.6% vs 4.5%). Three quarters (80.5%, 690 of 857) of the participants were asymptomatic, of which, 31 had positive IgM (4.5%) which consisted of 20 of 566 healthcare workers (3.5%) and 11 of 124 preprocedural patients (8.9%).ConclusionsCOVID-19 antibody test could detect a substantial number of potential silent spreaders in Thai community hospitals where the nasopharyngeal PCR was not readily available, and the antigen test was prohibited. Antibody testing should be encouraged for mass screening in a limited resource setting, especially in asymptomatic individuals.Trial registrationTCTR20200426002.

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The seroprevalence of SARS-CoV-2 antibodies among health care workers before the era of vaccination: a systematic review and meta-analysis

Cited by 49 publications

References 49 publications

Predictors of COVID-19 among Healthcare Workers who were Exposed to COVID-19

Predictors of COVID-19 among Healthcare Workers who were Exposed to COVID-19

Seroprevalence of the SARS-CoV-2 antibody in healthcare workers: a multicentre cross-sectional study in 10 Colombian cities

COVID-19 seroprevalence among hospital staff and preprocedural patients in Thai community hospitals: a cross-sectional study

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