The Serological Relationship Between Human Milk and Blood Plasma

Hanson, Lars Å.

doi:10.1159/000229110

Cited by 43 publications

(23 citation statements)

References 4 publications

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“…No inhibiting activity against trypsin and elastase could be detected in the azregion in the electrophoresis of human milk. This agrees with reports that an-macroglobulin is not found in human milk (14,15). In serum from infants, trypsin inhibiting activity was detected in the al-and a*-region, but in urine in the al-region only.…”

Section: Discussionsupporting

confidence: 93%

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Protease Inhibitors in Human Milk

Lindberg

1979

Pediatr Res

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Summarystandard serum for the measurements of the concentration of a,-Protease inhibitors (inhibiting trypsin, chymotrypsin, and elastase) were demonstrated in human milk from birth to 4 months after delivery. No pepsin inhibitor was found. The protease inhibitors were localized in the al-region-inhibiting trypsin, chymotrypsin, and elastase-and in a more cathodal region-inhibiting chymotrypsin-in agarose gel electrophoresis of human milk. alantitrypsin and antichymotrypsin were demonstrated by crossed immunoelectrophoresis. Electroimmunoassay showed the concentration of a,-antitrypsin in 1st day milk to be 109% and the concentration of antichymotrypsin was 116% of that of adult serum. The concentrations d&;eased during the 1st wk; from 1 wk to 4 months they were 1.6% for a,-antitrypsin and 3.84% for antichymotrypsin of those of adult serum. One ml of human milk from the first 3 days inhibits, by enzymatic methods, 0-150 pg (mean value, 70 pg) trypsin. Milk from 1 week after delivery and later inhibits 0-65 pg (mean value, 38 pg) trypsin per ml.

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Section: Discussionsupporting

confidence: 93%

“…%, m e a n value rt_ SEM. al-antitrypsin was previously found in human milk (15). In the present study, crossed immunoelectrophoresis demonstrated alantitrypsin in the same region where the protease inhibiting activity was found.…”

Section: Discussionsupporting

confidence: 84%

Protease Inhibitors in Human Milk

Lindberg

1979

Pediatr Res

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“…Anti-normal human plasma (anti-HP) sera from rabbits (Behringwcrke) and from horses (Nos. 13, 511 and 512 from the Pasteur Institute, Paris) were used as well as immune sera from sheep prepared as described earlier (23). The bleedings of the sheep anti-HP sera used did not contain discernablc quantities of antibodies against ¡' >2.\-globulin or the Bence-Jones proteins I and II.…”

Section: Methodsmentioning

confidence: 99%

“…One of them was absorbed with y-globulin to render it more specific. Methods The double diffusion-in-gel technique of O uchterlony (58) slightly modified by H anson (23) was used as well as the micromodification described by Wadsworth (72 (23,73). The comparative immune electrophoretic method was employed as described by Wadsworth and Hanson (23.…”

Section: Methodsmentioning

confidence: 99%

Comparative Immunological Studies of the Immune Globulins of Human Milk and of Blood Serum

Hanson¹

1961

Int Arch Allergy Immunol

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223

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“…saliva [14, 12,8] tears [14, 0] bronchial secretions [7,9], nasal secretions [11] and milk [3,4], The secretion from Case 2, while more difficult to resolve by agar gel electrophoresis on account of its extrem ely sticky character, gave electrophoretic p attern s suggesting the same predom inance id' the yA -im m uno globulin fraction.…”

Section: Discussionmentioning

confidence: 99%