The serological pattern of autoantibodies to the Ro52, Ro60, and La48 autoantigens in primary Sjögren's syndrome patients and healthy controls

Garberg, Hilde; Jönsson, Roland; Brokstad, Karl Albert

doi:10.1080/03009740510017940

Cited by 41 publications

(29 citation statements)

References 7 publications

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“…Another prominent feature of SS is the high production of autoantibodies against the intracellular proteins Ro/SSA and La/SSB, which can be detected in both the peripheral blood [20][21][22] and SG [23][24][25] of SS patients. Recently, it was reported that most primary SS patients produce autoantibodies many years before symptom onset [26,27].…”

Section: Introductionmentioning

confidence: 99%

Adipose tissue is prominent in salivary glands of Sjögren’s syndrome patients and appears to influence the microenvironment in these organs

et al. 2016

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A minor salivary gland (SG) biopsy with focal lymphocytic sialadenitis and a focus score of ≥1 is today's widely accepted pathological finding confirming the SG component of Sjögren's syndrome (SS). Adipocytes can occupy a large percentage of the SG area although little is known about their significance in SS lesions. This study aimed to characterise adipose tissue infiltration in labial SG biopsies from 27 SS patients and 28 non-SS sicca controls. Biopsies were evaluated by one oral pathologist and assessed for focus score, acinar atrophy, fatty replacement and non-specific chronic inflammation. Moreover, to explore the SG microenvironment, immunohistochemical staining of paraffin-embedded SG tissue was performed using interleukin-6 (IL-6). The fatty replacement was evident in all SS patients possessing autoantibodies (Ro/SSA and/or La/SSB) as well as a positive SG biopsy (focus score ≥1). Additionally, 62% of SS patients having autoantibodies but a negative biopsy showed fatty infiltration (FI) while non-SS controls demonstrated fatty replacement in only 32% of the cases. Overall, the SS group (mean age 53.0 years) had a significantly higher incidence (p value 0.005) of FI than the non-SS controls (mean age 54.8 years). Interestingly, adipocytes were located in IL-6 rich areas, and IL-6 positive adipocytes were detected. As fat deposition seems to be more recurrent in SGs affected by SS, we propose the assessment of adipose tissue replacement as a helpful tool for diagnostic evaluation in SS. Detection of IL-6 positive adipocytes suggests their involvement in immune reactions. Still, functional studies are needed to investigate the SG microenvironment further.

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Section: Introductionmentioning

confidence: 99%

Adipose tissue is prominent in salivary glands of Sjögren’s syndrome patients and appears to influence the microenvironment in these organs

et al. 2016

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“…The autoantibody concentrations were generally higher in sera from Sjo¨gren's syndrome patients and posses a more heterogeneous autoantibody repertoire then healthy subjects with regard to the number of autoantigens and antibody isotypes (Garberg et al, 2005).…”

Section: B Cells and Autoantibodiesmentioning

confidence: 99%

Sjögren's Syndrome

Jönsson

Brun

2010

Encyclopedia of Life Sciences

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Sjögren's syndrome is a lymphoproliferative disease with autoimmune features characterized by mononuclear cell infiltration of exocrine glands, notably the lacrimal and salivary glands (autoimmune exocrinopathy). These lymphoid infiltrations lead to dryness of the eyes (keratoconjunctivitis sicca), dryness of the mouth (xerostomia) and frequently, dryness of the nose, throat, vagina and skin. Sjögren's syndrome is associated with the production of autoantibodies because B‐cell activation is a consistent immunoregulatory abnormality. The spectrum of the disease extends from an organ‐specific autoimmune disorder to a systemic process (musculoskeletal, pulmonary, gastric, haematologic, dermatologic, renal and nervous system involvement). Sjögren's syndrome may occur alone (primary) or in association with almost any of the autoimmune rheumatic diseases (secondary), the most frequent being rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Sjögren's syndrome also is associated with an increased risk of B‐cell lymphoma development. Current treatments are mainly symptomatic.

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“…Ro, a ribonucleoprotein to which autoantibodies can be detected in up to 75% of human patients with SS [4], has a role in the etiology and pathology of SS as yet uncertain. Studies have shown that reciprocal spreading to the Ro52, Ro60, and La polypeptides occurs after immunization with a single component.…”

Section: Ro Peptidementioning

confidence: 99%

“…Histopathologically, SS is characterized by progressive focal mononuclear cell infiltration of the exocrine glands [2], destruction and/or functional defect [3], leading to clinical symptoms of dry mouth and dry eyes (xerostomia and keratoconjunctivitits sicca, respectively). Patients frequently present with autoantibodies to intracellular ribonucleoproteins such as Ro/SSA and/or La/SSB [4] and rheumatoid factor (RF) [1].…”

Section: Introductionmentioning

confidence: 99%

Animal Models of Sjögren’s Syndrome

Jonsson

Delaleu

Jönsson

2007

Clinic Rev Allerg Immunol

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Sjögren's syndrome is an autoimmune, chronic inflammatory disease characterized by focal mononuclear cell infiltration of exocrine tissues, accompanied by loss of secretory function. The pathogenesis of autoimmune diseases is complex and, therefore, difficult to study in vitro. As of today, the role of initiating factors remains obscure, clinical symptoms develop late, and there are no tests for early diagnosis of SS. Hence, the disease is difficult to detect and treat. Animal models may provide insights into the identification of target antigens, narrowing the relevant pathological immune mechanisms, and to study the evolution of tissue pathology. This review summarizes current knowledge on murine strains, both spontaneous and induced models, used to study Sjögren's syndrome. Special attention is paid to the characteristics of different strains regarding their properties to mimic specific aspects or stages of the disease.

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The serological pattern of autoantibodies to the Ro52, Ro60, and La48 autoantigens in primary Sjögren's syndrome patients and healthy controls

Abstract: We found a distinct and significant difference in the serum antibody specificity and immunoglobulin isotype pattern between SS patients and matched controls. This variance may point to different mechanisms by which these autoantibodies are generated.

Cited by 41 publications

References 7 publications

Adipose tissue is prominent in salivary glands of Sjögren’s syndrome patients and appears to influence the microenvironment in these organs

Adipose tissue is prominent in salivary glands of Sjögren’s syndrome patients and appears to influence the microenvironment in these organs

Sjögren's Syndrome

Animal Models of Sjögren’s Syndrome

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