“…With a prophenolase such combination might permit configurational changes in the molecule which unmask the catalytic centre. In this connexion, it is of interest that the results of studies of the combination of albumin with large anions (Karusch, 1952) or SDS (Neurath & Putnam, 1945) suggest that unfolding or expansion of the protein molecule takes place as the number of bound ions increases.…”