The Serological Classification of Corynebacterium Equi

Bruner, D. W.; Dimock, W. W.; Edwards, P. R.

doi:10.1093/infdis/65.1.92

Cited by 14 publications

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“…In phagocytosis the following events occur sequentially: [1] attraction between bacterium and phagocyte, [2] ingestion, and [3] degranulation and intracellular digestion. It seems that strains ATCC 33704 and 33705 are resistant to each step in vitro and in vivo; strains ATCC 33702 and 33706 are resistant to ingestion but not to digestion; strain ATCC 33703 is resistant to digestion but not to ingestion; and strain ATCC 33707 is not resistant to any step.…”

Section: Discussionmentioning

confidence: 99%

“…Although not proven, the organism is thought to be able to survive in equine macrophages (3). Serologic studies of R. equi indicate that there is a considerable antigenic heterogeneity among strains of the organism (2,14,16). The relationship between the capsular serotypes and the pathogenicity of the organism is not known, and the exact mechanism by which the capsule functions as a virulence factor has not yet been established (1).…”

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confidence: 99%

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Correlation of In Vitro Properties of Rhodococcus (Corynebacterium) equi with Virulence for Mice

Takaı̈

Michizoe

Matsumura

et al. 1985

Microbiology and Immunology

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To study the virulence of Rhodococcus (Corynebacterium) equi, seven ATCC strains of different serotypes were tested for their LD50 in mice, clearance of the organism from the lungs and spleen following intravenous or intratracheal inoculation, and in vitro interaction with murine peritoneal macrophages. Strains ATCC 33704 and 33705 were virulent for mice and multiplied in the lungs and spleen, resulting in death of the animal in 5 days. The other five strains were avirulent for mice. The number of bacteria in the lungs and spleen of mice given these five strains decreased immediately. Pulmonary clearance of strains ATCC 33703, 33706, and 33707 was significantly more rapid than that of the virulent strains ATCC 33704 and 33705 12 hr after inoculation. Complete clearance of the avirulent strain ATCC 33707 occurred by day 14, while that of virulent ATCC 33704 and 33705 strains occurred by day 30. The virulent strains ATCC 33704 and 33705 were resistant not only to phagocytosis but also to intracellular killing by macrophages. Strains ATCC 33702 and 33706 were rapidly killed by macrophages although they were rather resistant to phagocytosis. Strain ATCC 33703 was easily phagocytized though resistant to killing by macrophages. The most avirulent strains, ATCC 33707 and 6939, were easily phagocytized and rapidly killed by macrophages. These results indicate that virulence appeared to be related to the ability of the organisms to resist clearance from the lungs and spleen and to resist phagocytosis and intracellular killing by macrophages.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Correlation of In Vitro Properties of Rhodococcus (Corynebacterium) equi with Virulence for Mice

Takaı̈

Michizoe

Matsumura

et al. 1985

Microbiology and Immunology

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“…This spectrum of disease is similar to that observed in horses and in humans. Miscellaneous older reports record the isolation of R. equi from aborted fetuses and from animals with mastitis and metritis (18,19,35,138). The organism has been isolated from ulcerative lymphangitis in cattle (120), apparently following skin wounds made by thorns.…”

Section: Natural Infections In Other Speciesmentioning

confidence: 99%

Rhodococcus equi: an animal and human pathogen

1991

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Recent isolations of Rhodococcus equi from cavitatory pulmonary disease in patients with AIDS have aroused interest among medical microbiologists in this unusual organism. Earlier isolations from humans had also been in immunosuppressed patients following hemolymphatic tumors or renal transplantation. This organism has been recognized for many years as a cause of a serious pyogranulomatous pneumonia of young foals and is occasionally isolated from granulomatous lesions in several other species, in some cases following immunosuppression. The last decade has seen many advances in understanding of the epidemiology, pathogenesis, diagnosis, treatment, and immunity to infection in foals. The particular susceptibility of the foal is not understood but can be explained in part by a combination of heavy challenge through the respiratory route coinciding with declining maternally derived antibody in the absence of fully competent foal cellular immune mechanisms. R. equi is largely a soil organism but is widespread in the feces of herbivores. Its growth in soil is considerably improved by simple nutrients it obtains from herbivore manure. About one-third of human patients who have developed R. equi infections had contact in some way with herbivores or their manure. Others may have acquired infection from contact with soil or wild bird manure. R. equi is an intracellular parasite, which explains the typical pyogranulomatous nature of R. equi infections, the predisposition to infection in human patients with defective cell-mediated immune mechanisms, and the efficacy of antimicrobial drugs that penetrate phagocytic cells.

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“…The acid extracta of C. equi organisms used in the precipitation tests were prepared according to the method of Bruner, Dimock and Edwards (1939). The precipitation tests were carried out by the qualitative method-0-3 ml.…”

Section: Serological Worlcmentioning

confidence: 99%

“…They were prepared according to the method of Bruner, Dimock and Edwards (1939). Before the antigen preparations were U9ed in the complemeut fixation test they were suitably diluted so that the first tube, in the teat proper, contained 50 p.e.…”

Section: Vomptement Fixation Testsmentioning

confidence: 99%

STUDIES ON STRAINS OF CORYNEBACTERIUM EQUI ISOLATED FROM PIGS

Woodroofe

1950

Aust J Exp Biol Med

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The Serological Classification of Corynebacterium Equi

Cited by 14 publications

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Correlation of In Vitro Properties of Rhodococcus (Corynebacterium) equi with Virulence for Mice

Correlation of In Vitro Properties of Rhodococcus (Corynebacterium) equi with Virulence for Mice

Rhodococcus equi: an animal and human pathogen

STUDIES ON STRAINS OF CORYNEBACTERIUM EQUI ISOLATED FROM PIGS

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