The Seriousness of Chronic Venous Disease: A Review of Real-World Evidence

Abstract

Chronic venous disease (CVD) is a prevalent condition that tends to worsen with age. Patients initially seek treatment to relieve symptoms of leg pain, discomfort, heaviness and swelling, all of which impact their quality of life. As the disease increases in severity to include varicose veins, skin changes, and venous ulcer, the demand for treatment increases while the quality of life further diminishes. The prevalence of CVD is highest in Western countries where it already consumes up to 2% of healthcare budgets. With the aging of the global population, the prevalences of CVD and severe CVD are projected to increase substantially, foretelling unsustainably large increases in the healthcare resources and costs needed to treat CVD patients in the coming decades. Effective venoactive drug treatments and ablation procedures are available that provide symptom relief, improve quality of life, slow disease progression, and promote ulcer healing. In addition, venoactive drug treatments may be highly cost-effective. However, there is evidence that physician awareness of CVD is suboptimal and that many patients with CVD are not being treated or referred to specialists according to established guidelines. To decrease this treatment gap and prevent unnecessary disease progression, international guidelines are available to help physicians consider CVD treatment options and refer patients when warranted. Improved disease awareness and appropriate early treatment may help reduce the coming burden of CVD.Funding: Servier.

Treatment of patients with lower limb varicose veins disease

“…Review ние), которые значимо влияют на качество жизни и приводят к потере работоспособности [6][7][8].…”

IGFBP6 regulates vascular smooth muscle cell proliferation and morphology via cyclin E–CDK2

“…In Western countries, the prevalence of CVD is highest and already consumes up to 2% of healthcare budgets (Davies, 2019). Varicose veins are the most common venous disorders and affect around 25-40% of the adult population (Hamann et al, 2019).…”

Time trends and social security burden of temporary work disability due to chronic venous disease in Brazil

“…Chronic venous disease (CVD) is a worldwide problem and has high prevalence and significant socioeconomic implications [1][2][3]. Approximately half of the adult population has some form of venous disease [4,5].…”

“…Despite the evolution in the treatment of CVD in recent years, work disability due to CVD remains frequent, and the reasons are little known. The high prevalence of CVD, its significant socioeconomic impact [1][2][3], and the need to plan public policies aimed at preventing disabilities justify the initiation of this study. The objective of this study is to analyze the time trends and social security burden of temporary work disability due to CVD in Brazil between 2005 and 2014.…”