The sequential hypothesis on sleep function. II. A correlative study between sleep variables and newly synthesized brain DNA

Ambrosini, Maria Vittoria; Sadile, A.G.; Carnevale, U.A. Gironi; Mattiaccio, Alessandro; Giuditta, Antonio

doi:10.1016/0031-9384(88)90197-7

Cited by 35 publications

(17 citation statements)

References 10 publications

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“…In this study, we have used a two-way active avoidance-learning task that involves both hippocampal and non-hippocampal structures for learning and memory processing (Smith and Young 1980;Ambrosini et al, 1988;Ramirez and Carrer, 1989;Bramham et al, 1994). The involvement of the hippocampus and some non-hippocampal structures in learning and memory processing is supported by many other studies (Squire et al, 1990;LeDoux, 1992;Silva et al, 1992;Izquierdo et al, 1995;Hatfield et al, 1996;Rempel-Clower et al, 1996;Poremba and Gabriel, 1997;Young et al, 1997;Gallagher et al, 1999;Vazdarjanova and McGaugh, 1999).…”

Section: Methodsmentioning

confidence: 85%

“…In this study, we have used a TWAA-learning task that involves both the hippocampus and the amygdala (Smith and Young, 1980;Ambrosini et al, 1988;Ramirez and Carrer, 1989;Bramham et al, 1994;. One recent anatomical study provided evidence that P-wave-generating cells project monosynaptically to both hippocampal and non-hippocampal structures involved in learning processes (Datta et al, 1998).…”

Section: Methodological Considerationsmentioning

confidence: 99%

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Activation of Phasic Pontine-Wave Generator Prevents Rapid Eye Movement Sleep Deprivation-Induced Learning Impairment in the Rat: A Mechanism for Sleep-Dependent Plasticity

Datta¹,

Mavanji²,

Ulloor³

et al. 2004

J. Neurosci.

149

167

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Animal and human studies of sleep and learning have demonstrated that training on various tasks increases subsequent rapid eye movement (REM) sleep and phasic pontine-wave (P-wave) activity, followed by improvement in performance on the learned task. It is well documented that REM sleep deprivation after learning trials blocks the expected improvement in performance on subsequent retesting. Our aim was to test whether experimentally induced P-wave generator activation could eliminate the learning impairment produced by post-training REM sleep deprivation. Rats were trained on a two-way active avoidance-learning task. Immediately thereafter, two groups of those rats received a control vehicle (100 nl saline) microinjection and one group received a carbachol (50 ng in 100 nl saline) microinjection into the P-wave generator. The carbachol-injected group and one of the two control saline microinjected groups were selectively deprived of REM sleep during a 6 hr polygraphic recording session. All rats were then tested on the avoidance-learning task. The rats that received both the control saline injection and REM sleep deprivation showed learning deficits compared with the control saline-injected rats that were allowed to sleep normally. In contrast, the rats that received the carbachol microinjection and REM sleep deprivation demonstrated normal learning. These results demonstrate, for the first time, that carbachol-induced activation of the P-wave generator prevents the memory-impairing effects of post-training REM sleep deprivation. This evidence supports our hypothesis that the activation of the P-wave generator during REM sleep deprivation enhances a physiological process of memory, which occurs naturally during post-training REM sleep.

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Section: Methodsmentioning

confidence: 85%

Section: Methodological Considerationsmentioning

confidence: 99%

Activation of Phasic Pontine-Wave Generator Prevents Rapid Eye Movement Sleep Deprivation-Induced Learning Impairment in the Rat: A Mechanism for Sleep-Dependent Plasticity

Datta¹,

Mavanji²,

Ulloor³

et al. 2004

J. Neurosci.

149

167

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“…Several studies have investigated the synthesis of DNA and RNA during different vigilance states or after sleep deprivation [200][201][202][203][204][205]. For example, studies in rabbits showed positive correlations between RNA synthesis in neocortical neurons and EEG synchronization during sleep [202,203].…”

Section: Cellular and Molecular Levelmentioning

confidence: 99%

A role for sleep in brain plasticity

Dang‐Vu

Desseilles²,

Peigneux

et al. 2006

Pediatric Rehabilitation

107

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The idea that sleep might be involved in brain plasticity has been investigated for many years through a large number of animal and human studies, but evidence remains fragmentary. Large amounts of sleep in early life suggest that sleep may play a role in brain maturation. In particular, the influence of sleep in developing the visual system has been highlighted. The current data suggest that both Rapid Eye Movement (REM) and non-REM sleep states would be important for brain development. Such findings stress the need for optimal paediatric sleep management. In the adult brain, the role of sleep in learning and memory is emphasized by studies at behavioural, systems, cellular and molecular levels. First, sleep amounts are reported to increase following a learning task and sleep deprivation impairs task acquisition and consolidation. At the systems level, neurophysiological studies suggest possible mechanisms for the consolidation of memory traces. These imply both thalamocortical and hippocampo-neocortical networks. Similarly, neuroimaging techniques demonstrated the experiencedependent changes in cerebral activity during sleep. Finally, recent works show the modulation during sleep of cerebral protein synthesis and expression of genes involved in neuronal plasticity.Keywords: Sleep, plasticity, brain development, memory, functional neuroimaging La idea de que dormir pudiera estar involucrado en la plasticidad cerebral ha sido investigada por muchos añ os a través de un gran nú mero de estudios en animales y humanos, pero la evidencia permanece fragmentada. Grandes cantidades de sueñ o en los inicios de la vida sugiere que el sueñ o puede tener un papel en la maduració n cerebral. En particular ha sido remarcada la influencia del sueñ o en el desarrollo del sistema visual. Los datos actuales sugieren que las etapas de sueñ o REM y no-REM podrían ser importantes para el desarrollo cerebral. Tales hallazgos demandan la necesidad de un manejo ó ptimo del sueñ o pediátrico. En el cerebro adulto, el papel del sueñ o en el aprendizaje y la memoria es enfatizado por estudios a niveles conductual, sistémico, celular y molecular. Primero, se reporta que las cantidades de sueñ o aumentan después de una tarea de aprendizaje y la falta del sueñ o limita la adquisició n y consolidació n de la tarea. A nivel sistémico, los estudios neurofisioló gicos sugieren posibles mecanismos para la consolidació n de los rastros de memoria. Esto implica a las redes tálamo-cortical y la hipocampo-neocortical. De igual manera, las técnicas de neuroimagen demostraron los cambios dependientes de la experiencia, en la actividad cerebral durante el sueñ o. Finalmente, trabajos recientes muestran durante el sueñ o la modulació n de la síntesis proteica cerebral y la expresió n de los genes involucrados en la plasticidad neuronal.

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“…The Contribution of sleep to memory consolidation Review alternative possibility, the 'double-step' hypothesis, assumes that the succession of NREMS and REMS was required for optimal memory consolidation [46], whatever the memory system considered. Some evidence has supported this hypothesis in animal experiments [47][48][49][50][51]. In humans, the evidence remains scarce.…”

Section: Behavioral Effectsmentioning

confidence: 97%

Contribution of sleep to memory consolidation

Bourdiec¹,

Muto²,

Mascetti³

et al. 2009

Future Neurol.

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A growing body of evidence indicates that sleep promotes memory consolidation; the protracted process by which fresh, labile memories are reorganized into stable memories [1]. Although the first evidence for this effect was collected more than a century ago [2], the potential underlying neural mechanisms are only just beginning to be conceptualized and characterized experimentally.Memory consolidation is a hackneyed expression that may take different meanings. At the cellular level, consolidation is often framed in terms of long-term experience-dependent changes in neural responsiveness, usually resulting from modifications in synaptic strength (Figure 1) [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. At the systems level, consolidation relates to the progressive reorganization of memories within brain circuits [20][21]. From a behavioral perspective, consolidation refers to an improvement of performance between practice sessions or a reduction of vulnerability of a memory trace after the acquisition of a novel skill [22][23], although other phenomena such as automatization [24][25] or generalization [26] might also be considered as behavioral markers of memory consolidation (Figure 1).It is therefore not surprising that the effects of sleep on memory consolidation were reported at various levels of description. The early studies assessed the effects of sleep on different memory systems at the behavioral level. They contrasted the influence of non-rapid eye movement sleep (NREMS) with rapid eye movement sleep (REMS) on declarative and procedural memories, respectively. As the understanding of the effects of sleep on memory consolidation progressed, the hypotheses were increasingly framed in terms of the neural processes occurring during NREMS or REMS, and specifically, those associated with phasic events such as slow waves, spindles or phasic REMS. This paper is organized into five sections. The first section summarizes the key findings of behavioral studies that suggest an effect of sleep on memory. Earlier reviews have already covered these results in detail [27][28][29][30][31]. The present article highlights recent data that call for a reappraisal of these effects that, although indisputable, seem quantitatively modest. The article also emphasizes the higher sensitivity of neuroimaging and neurophysiological measures in characterizing the effects of sleep on memory. The following sections review the two main hypotheses that are currently being tested, namely the homeostatic synaptic downscaling and the sleep-dependent systems-level consolidation. The final two sections emphasize the intervention of post-training REMs and wakefulness in memory processing. Behavioral effectsThe recognition of different memory systems helped to characterize the effects of sleep on memory consolidation (Figure 2). On the procedural side, spontaneous gains in performance in a motor sequence learning task were observed between initial training and later testing, specifically if the interval included sleep rather ...

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The sequential hypothesis on sleep function. II. A correlative study between sleep variables and newly synthesized brain DNA

Cited by 35 publications

References 10 publications

Activation of Phasic Pontine-Wave Generator Prevents Rapid Eye Movement Sleep Deprivation-Induced Learning Impairment in the Rat: A Mechanism for Sleep-Dependent Plasticity

Activation of Phasic Pontine-Wave Generator Prevents Rapid Eye Movement Sleep Deprivation-Induced Learning Impairment in the Rat: A Mechanism for Sleep-Dependent Plasticity

A role for sleep in brain plasticity

Contribution of sleep to memory consolidation

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