The Sepsis Saga: Sepsis-3—Ready for Prime Time?

Motalib, Sakib; Dries, David J.

doi:10.1016/j.amj.2016.06.003

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sepsis is a clinical and complex biological syndrome, defined as life-threatening organ dysfunction caused by an irregular host response to infection [ 6 ]. The cytokine storm is a potentially fatal systemic inflammatory state caused by high amounts of circulating cytokines and immune cell hyperactivation from sepsis [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Hemoperfusion techniques using Jafron HA330 cartridge combined with BBraun Dialog+ dialysis machine in patient with coronavirus disease 2019 pneumonia and septic shock: a case report

2023

View full text Add to dashboard Cite

Background The use of hemoperfusion for cytokine removal and inflammatory mediators is increasingly intense, especially in coronavirus disease 2019 patients who are already known to the general public for having cytokine storms. However, we have known about these cytokine storms for a long time in the critical care world. One of the modalities to remove cytokines is to use filtration and adsorption techniques with continuous renal replacement therapy. The use of continuous renal replacement therapy is usually constrained by its very high cost compared with standard care, especially in Indonesia, where health costs are covered by national health insurance. In this case, we use hemodialysis and hemoperfusion, using a dialysis machine, which is more cost-effective and easy to use. Case presentation We used the Jafron HA330 cartridge, modified for the BBraun Dialog+ dialysis machine. This case report presents an 84-year-old Asian man with septic shock due to pneumonia, congestive heart failure, and acute chronic kidney disease accompanied by fluid overload. After undergoing hemodialysis and hemoperfusion separately, there was a gradual and significant clinical improvement. Clinical indicators, including the vasopressor inotropic score and infection markers, should all be considered when deciding whether to begin hemodialysis and hemoperfusion. Conclusion In general, using hemoperfusion to treat septic shock patients can reduce the length of stay in the intensive care unit, and morbidity and mortality.

show abstract

Section: Discussionmentioning

confidence: 99%