The separation of nine components and two inactivators of components of component in human serum

Vroon, David H.; Schultz, Duane R.; Zarco, R. M.

doi:10.1016/0019-2791(70)90029-7

Cited by 85 publications

(36 citation statements)

References 15 publications

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“…At each visit, laboratory profiles taken included complete blood count, platelet count, ESR, automated biochemical profile (SMAC 121, urinalysis, prothrombin time, and partial thromboplastin. Initial studies included rheumatoid factor, antinuclear antibody, functional hemolytic assays for c6mplement components C2, C3, and C4 (12,13), and early morning serum cortisol. The latter tests were repeated during and at the completion of the venom therapy (visits 3 and 4) and twice during the followup (visits 8 and 12).…”

Section: 6mentioning

confidence: 99%

The effects of a partially purified fraction of an ant venom in rheumatoid arthritis

Altman

Schultz

Collins‐Yudiskas

et al. 1984

Arthritis & Rheumatism

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A partially purified extract of an ant venom from the South American tree ant Pseudomyrmex sp. was tested in a double-blind, controlled study of patients with rheumatoid arthritis. Venom treated patients demonstrated an improvement in global efficacy and a decrease in the number of tendedpainful joints and swollen joints. Swollen joint index improved in 60% of venom treated patients. Other parameters did not demonstrate significant change. Reduction of joint swelling was followed by symptomatic improvement that was sometimes delayed by weeks. Reactions were limited to erythema at the injection site (all patients), local pruritis (two-thirds of the patients), and fever with malaise (onethird of the patients). Further study of this venom in rheumatoid arthritis appears warranted in view of its apparent favorable efficacy-to-toxicity ratio.Some animal products have been thought to have special curative powers (1). In general, the use of venoms is recent (i.e., the past 200 years) (2). Viper venoms, particularly cobra, and honeybee venoms have been the most popular. Despite episodic empha-

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Section: 6mentioning

confidence: 99%

The effects of a partially purified fraction of an ant venom in rheumatoid arthritis

Altman

Schultz

Collins‐Yudiskas

et al. 1984

Arthritis & Rheumatism

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“…Serum levels of C4 and C3 were determined by haemolytic assays, as previously described (Vroon, Schultz and Zarco, 1970;Moake and Schultz, 1975 (Fearon et al 1975). This late activation was considered to be "delayed ".…”

Section: Methodsmentioning

confidence: 99%

Screening Tests in Chemical Carcinogenesis

Fox¹

1976

Br J Cancer

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Summary.-Serum complement levels were assayed in 26 patients with disseminated cancer, who received immunotherapy with infusion of C. parvum. Complement activation, indicated by the consumption of C3 or C4 or both, was found in 46°' of the patients.Serum samples showed direct correlation between decreased C3 and conversion of C3 proactivator, whereas such conversion did not occur when C4 alone was decreased. It is concluded that the bypass (properdin) pathway was activated in patients in whom C3 consumption was detected, while the classical (Cl) pathway was activated in the patients with C4 consumption unaccompanied by C3 decrease. Direct correlation was observed between delayed cutaneous hypersensitivity reactions to recall antigens and the incidence of C. parvum-associated complement activation.

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“…Human C4 was isolated according to the method of Okuda and Tachibana (1980), and human C2 was obtained by the method of Vroon et al (1970 …”

Section: Complement Componentsmentioning

confidence: 99%

Development of a hemolytic assay for mouse complement components in sera and the variation of their levels with age.

Fukuoka

Seino

Okuda

et al. 1982

Tohoku J. Exp. Med.

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The separation of nine components and two inactivators of components of component in human serum

Cited by 85 publications

References 15 publications

The effects of a partially purified fraction of an ant venom in rheumatoid arthritis

The effects of a partially purified fraction of an ant venom in rheumatoid arthritis

Screening Tests in Chemical Carcinogenesis

Development of a hemolytic assay for mouse complement components in sera and the variation of their levels with age.

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