The separation of date (Phoenix dactylifera) sterols by liquid chromatography

Kikuchi, Nobu; Miki, Taihei

doi:10.1007/bf01196983

Cited by 35 publications

(18 citation statements)

References 4 publications

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“…Sterols of plants are called phytosterols and possess myriad health benefits (Liolios et al, 2008). Kikuchi and Miki (1978) analyzed the sterols of date fruit and observed that they contain cholesterol, campesterol, stigmasterol, β-sitosterol and isofucosterol (Fig. 2).…”

Section: Sterolsmentioning

confidence: 99%

A review of the chemistry and pharmacology of the date fruits (Phoenix dactylifera L.)

Baliga

Kandathil

et al. 2011

Food Research International

411

304

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Section: Sterolsmentioning

confidence: 99%

A review of the chemistry and pharmacology of the date fruits (Phoenix dactylifera L.)

Baliga

Kandathil

et al. 2011

Food Research International

411

304

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“…Investigations revealed that date palm possesses antioxidant, antimutagenic (Vayalil 2002), antihaemolytic (Abuharfeil et al 1999), antiviral (Jassim and Naji 2010), antifungal (Shraideh et al 1998), anti-inflammatory (Mohamed and Al-Okabi 2004), antihyperlipidemic (Al-Maiman 2005), hepatoprotective (Al-Qarawi et al 2004; Sheikh et al 2014), nephroprotective (Al-Qarawi et al 2008), gastroprotective (Al-Qarawi et al 2005), anticancer (Ishurd and Kennedy 2005), immunostimulating (Puri et al 2000), and gonadotropic (El-Mougy et al 1991) activity. The date fruit is also rich in pharmacologically important phytochemical constituents including simple pheolics ( p -hydroxy benzoic acid, protocatechuic acid, gallic acid, vanillic acid, syringic acid), phenylpropanoids (cinnamic acid, caffeic acid, o -caffeoyl shikimic acid, ferulic acid, sinapic acid, o -coumaric acid, p -coumaric acid) (Mansouri et al 2005), carotenoids (β-carotene, lutein), sterols (cholesterol, campesterol, stigmasterol, β-sitosterol, isofucosterol) (Kikuchi and Miki 1978), flavonoids and their glycosides (catechin, epi -catechin, quercetin, luteolin, apigenin) (Hong et al 2006), procyaninidins (Hong et al 2006), and anthocyanins (Al-Farsi et al 2005). …”

Section: Introductionmentioning

confidence: 99%

Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (Phoenix dactylifera)

Sheikh

Zihad

Sifat

et al. 2016

Orient Pharm Exp Med

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In addition to the rich nutritional value, date palm is also used in various ethnobotanical practices for the treatment of various disease conditions. Present investigation was undertaken to examine the neuropharmacological and antinociceptive effect of the ethanol extract of three date cultivars growing in Saudi Arabia, namely Ajwah, Safawy and Sukkari. Neuropharmacological effect was observed by pentobarbitone induced sleeping time, open field, and hole board test. Antinociceptive activity was tested by acetic acid induced writhing and hot plate test. The date extracts were also subjected to HPLC analysis to detect the presence of common bioactive polyphenols. All the three date extracts extended the pentobarbitone induced sleeping time, reduced locomotor activity in open field test and reduced exploratory behaviour in hole board test in mice. The extracts also reduced acetic acid induced writhing and delayed response time in hot plate test. The activities were stronger for Ajwah than the other two date cultivars. HPLC analysis indicated the presence of trans-ferulic acid in all three cultivars, while (+)-catechin and (−)-epicatechin only in Ajwah and Safawy. The observed neuropharmacological and analgesic activity could be partly due to the presence of (+)-catechin, (−)-epicatechin and trans-ferulic acid, three important plant polyphenols well known for their neuroprotective activity and their ability to exert antioxidant activity on brain cells. Present investigation also supports the ethnobotanical use of date palm to provide ameliorating effects in pain and CNS disorders.Electronic supplementary materialThe online version of this article (doi:10.1007/s13596-016-0239-5) contains supplementary material, which is available to authorized users.

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“…DPP and male palm flowers were traditionally regarded as aphrodisiacs and fertility enhancers (Zaid, 1999;Khare, 2007). Pollen mixed with honey has been eaten as an aphrodisiac since ancient times (Kikuchi & Miki, 1978). Reports have also identified microelements contained within DPP that contain sterols and other agents that might influence male fertility (Bennet et al, 1966;Bajpayee, 1997).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of date palm (Phoenix dactyliferaL.) pollen extract on cadmium-induced testicular toxicity

2012

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Cadmium (Cd) is a well-known testicular toxicant. This study was designed to explore the long-term effects of a single low dose of Cd on spermatogenesis, and testicular dysfunction and oxidative stress, and the therapeutic potential of date palm pollen extract (DPP) in averting such reproductive damage. Adult male Wistar rats received a single intraperitoneal injection of CdCl2 (0 or 1 mg kg(-1) ). Twenty-four hours later, they started receiving DPP (0 or 40 mg kg(-1) ) orally, once daily for 56 consecutive days. Cd exposure caused significant reproductive damage via reduced weight of the reproductive organs, which includes spermatological damage (decreased sperm count and motility and increased rates of sperm abnormalities), increased oxidative stress (increased malondialdehyde and decreased reduced glutathione levels), histological alterations (necrosis, inefficient to completely arrest spermatogenesis and a reduced Johnsen's score) and decreased serum testosterone level. DPP restored spermatogenesis and attenuated the toxic effects of Cd on the reproductive system to the levels observed in the control animals. These findings support the hypothesis that the testis is particularly sensitive to Cd, which can cause testicular damage and infertility. Treatment with DPP can ameliorate the deleterious effects of Cd, probably by activating testicular endocrine and antioxidant systems.

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The separation of date (Phoenix dactylifera) sterols by liquid chromatography

Cited by 35 publications

References 4 publications

A review of the chemistry and pharmacology of the date fruits (Phoenix dactylifera L.)

A review of the chemistry and pharmacology of the date fruits (Phoenix dactylifera L.)

Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (Phoenix dactylifera)

Therapeutic effects of date palm (Phoenix dactyliferaL.) pollen extract on cadmium-induced testicular toxicity

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