The sensitization potential of some perfume ingredients tested using a modified Draize procedure

Sharp, D.W.

doi:10.1016/0300-483x(78)90009-4

Cited by 141 publications

(14 citation statements)

References 44 publications

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“…A.). 1-Decanol wurde von den Autoren als schwach sensibilisierend bezeichnet (Sharp 1978). Die Zahl der positiv reagierenden Tiere und die Reaktionsausprägungen sind jedoch nicht dokumentiert.…”

Section: Hautsensibilisierende Wirkungunclassified

1‐Decanol [MAK Value Documentation in German language, 2017]

Hartwig

2017

The MAK‐Collection for Occupational Health and Safety

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The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated 1‐decanol [ 112‐30‐1 ] to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints. Critical effects are irritation and the tumour‐promoting potential on the skin. Neither appropriate data in humans nor inhalation or oral studies of 1‐decanol with animals are available for derivation of a MAK value. An 8‐week feeding study in Wistar rats with the structurally related 1‐dodecanol resulted in a NOAEL of 100 mg/kg body weight and day. The same NOAEL is assumed for 1‐decanol. From this NOAEL, the concentration in workplace air was calculated according to the Commission's procedure to be 245 mg 1‐decanol/m 3 . However, as 1‐decanol is irritating and there are no studies of effects in the respiratory tract, a comparison with structurally‐related substances is indicated as well. The RD 50 values of 45 ml/m 3 and 50 ml/m 3 for 2‐ethylhexanol and 1‐octanol, respectively, are rather similar, which can also be assumed for 1‐decanol. Because of its similar irritating potency, the MAK value for 1‐decanol has been established at 10 ml/m 3 in analogy to 2‐ethylhexanol. As local effects are critical, the substance is assigned to Peak Limitation Category I. The excursion factor of 2 is set in analogy to 2‐ethylhexanol. From a synopsis of all data, 1‐decanol is classified in Pregnancy Risk Group C, despite the small difference between MAK value and NOAEC of 15 ml/m 3 for developmental toxicity. 1‐Decanol is not mutagenic in bacteria. There are no long‐term studies with 1‐decanol. Papillomas, squamous cell carcinomas and severe skin irritation occurred after 60‐week application to the skin of the mouse following initiation with 7,12‐dimethylbenz[a]anthracene. The maximum skin absorption of 10 mg is less than 25% of the systemically tolerable amount of 660 mg which is taken up by inhalation at the MAK value. There are no positive clinical findings of contact sensitization from 1‐decanol, nor are such effects expected from the structure and the comparison with homologous alcohols. Data for sensitization of the airways are not available.

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Section: Hautsensibilisierende Wirkungunclassified

1‐Decanol [MAK Value Documentation in German language, 2017]

Hartwig

2017

The MAK‐Collection for Occupational Health and Safety

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“…Numerous other comparison studies have been conducted (Buehler, 1965;Maguire, 1973;Magnusson, 1975;Buehler and Griffith, 1975;Griffith and Buehler, 1977;Magnusson andKligman, 1970, 1977;Sharp, 1978;Maurer et al, 1979). Almost without exception, each author found his method to be the best for his purposes.…”

Section: Guinea Pig Maximization Test (Gpmt) 11mentioning

confidence: 99%

Comparison of Skin Sensitization Methods: Landsteiner, Maguire and Guinea Pig Maximization

Horton¹,

Hall²

1981

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“…Induction with 0.1 ml of a 0.1 % 1-hexanol solution and provocation with 0.1 ml of the same solution applied intracutaneously or with a 10 % solution applied topically did not produce any effect. 1-Hexanol was classified as not sensitizing (Sharp 1978).…”

Section: Allergenic Effectsmentioning

confidence: 99%

1‐Hexanol [MAK Value Documentation, 1998]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 9 (1998) The article contains sections titled: Toxic Effects and Modes of Action Pharmacokinetics Effects in Man Effects on Animals Acute toxicity Allergenic Effects Reproductive and Developmental Toxicity Genotoxicity Carcinogenicity Other Effects Manifesto (MAK value, classification)

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The sensitization potential of some perfume ingredients tested using a modified Draize procedure

Cited by 141 publications

References 44 publications

1‐Decanol [MAK Value Documentation in German language, 2017]

1‐Decanol [MAK Value Documentation in German language, 2017]

Comparison of Skin Sensitization Methods: Landsteiner, Maguire and Guinea Pig Maximization

1‐Hexanol [MAK Value Documentation, 1998]

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