The sensitivity of Na⁺, K⁺ ATPase as an indicator of blood diseases

Abstract

Background: Blood-related hereditary diseases are widespread in Eastern and SouthWestern regions of Saudi Arabia until recently. In this study, we used Na

Perturbations of serum electrolyte levels in iron deficiency anemia - A comparative analysis

“…Although few studies, both in animals [20] and in humans [11] have linked IDA with altered serum electrolyte levels, the relationship between them has long been a topic of debate in the literature. Since IDA is recognized as major public health problem, the suggested relationship between the two assumes clinical importance.…”

“…[18] Several studies have shown variation in the erythrocyte membrane Na + K + ATPase activity was modulated by the changes in the differences resulting from hematological disorders. [11] Furthermore, an increase in red cell membrane permeability to sodium or potassium has been described in a variety of red cell disorders. Previous studies have stated that Na + K + ATPase activity is higher in the primary anemia patients.…”

“…[10] Several researchers reported that in IDA, the activity of red cell membrane-bound Na + K + ATPase is altered and due to this altered ATPase activity, serum sodium, and potassium levels are affected. [3,11,12] Salsbury et al stated that our dietary iron absorption has been mediated by potassium voltagegated channel subfamily E, member 2 (KCNE 2) which is single-pass integral membrane β subunit of a potassium ion channel. The disruption of this regulatory subunit may also alter the levels of potassium in IDA.…”

“…[3,11,12] Furthermore, few studies have reported changes in serum electrolyte levels in sickle cell anemia and [11,[13][14][15][16][17][18] β-thalassemia major. [11,19] Our interest in the distribution of serum electrolytes in IDA was stimulated by the observation of contradicting reports and also due to paucity of studies done relating the alterations of serum electrolyte levels in anemia. Hence, we aimed to evaluate the alterations in serum electrolyte levels in patients with IDA and comparing it with healthy subjects without anemia.…”

Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health

“…Consistent with this, NKA inhibition is associated with asthma [19,20] and chronic obstructive pulmonary disease (COPD) [21]. Furthermore, loss of NKA activity is associated with allergic diseases [22,23] including allergic rhinitis [24] and blood diseases including thalassemia and sickle cell anaemia [25]. Extensive studies show that NKA is essential for sperm mobility and male fertility [26,27,28,29].…”