The sensitivity and specificity of the 9-item Wearing-off Questionnaire

Stacy, Mark; Murphy, Jane M.; Greeley, David; Stewart, R. Malcolm; Murck, Harald; Meng, Xiangwen

doi:10.1016/j.parkreldis.2007.07.013

Cited by 71 publications

(67 citation statements)

References 9 publications

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“…This finding was also noticed in other studies, and draws attention to the importance of the presence of the four NMS in WOQ-9, although less referred but of great clinical significance. This is in agreement with the analysis of Stacy et al 14 , who found that the sensitivity and specificity of WOQ-9 are equivalent to a scale that only uses five motor items. Furthermore, even not listed in the questionnaire, the NMS are always self-reported by the patients, which reflect that these symptoms are substantially uncomfortable for them 21 .…”

Section: Discussionsupporting

confidence: 92%

“…The nine items of WOQ-9 were obtained by means of a retrospective statistical analysis of the WOQ-32 symptoms more frequent in the patients with WO followed by a canonical discriminant analysis to identify the symptoms that were better predictive to identify WO in the patients with WO and not detected by doctor's assessment from original WOQ-32 study 13 . The sensitivity of WOQ-9 was 96.2% and specificity 40.9%, proving its usefulness as a screening method 14 . As for the frequency of the WOQ-9 symptoms, either individually or collectively, the NMS were always neglected.…”

Section: Discussionmentioning

confidence: 92%

“…The original study that validated the WOQ-9 questionnaire showed high sensitivity and low specificity to detect WO when compared with the clinical evaluation by neurologists 14,19,20 . The higher the sensitivity the higher is the ability of WOQ-9 to detect WO, which also occurred in our assessed sample.…”

Section: Discussionmentioning

confidence: 99%

“…The WOQ-19 has the same sensitivity of the WOQ-32 12 . Finally, a questionnaire with nine symptoms (WOQ-9) was designed to facilitate the patients to answer it, while waiting for their routine consultations 13,14 . The nine items of WOQ-9 were obtained by means of a retrospective statistical analysis of the WOQ-32 symptoms more frequent in the patients with WO followed by a canonical discriminant analysis to identify the symptoms that were better predictive to identify WO in the patients with WO and not detected by doctor's assessment from original WOQ-32 study 13 .…”

Section: Discussionmentioning

confidence: 99%

“…Studies showed that either treatment option have similar results to improve motor fluctuation 7,8,9,10 . Many studies have verified whether questionnaires answered by patients are helpful to enhance the detection of WO 11,12,13,14 . This study aimed to assess whether WOQ-9 is an useful tool to assist neurologists to detect WO in clinical practice, increasing its identification.…”

mentioning

confidence: 99%

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Specificity and sensibility of 9-Itens Wearing-off Questionnaire in Brazilian Parkinson disease patient sample

Santos

Chien

Barbosa

2014

Arq. Neuro-Psiquiatr.

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Objective: (1) To evaluate whether the Nine Items Questionnaire (WOQ-9) for the detection of wearing-off (WO) in Parkinson Disease (PD), by means of its screening ability, is a helpful tool to assist neurologists in diagnosing WO; (2) To determine the sensitivity and the specificity of a free Brazilian Portuguese translation of WOQ-9. Method: A sample obtained by convenience included 60 patients. The WOQ-9 was answered by the patients themselves before their routine consultations. The detection of the WO by the WOQ-9 was compared with the neurologist assessment. Statistical significance was 5%. Results: The WOQ-9 showed sensitivity of 100%, specificity of 10.3%, positive and negative predictive values of 54.4% and 100% respectively. The identification of WO by the WOQ-9 was congruent in 54.5% of cases with neurological evaluation. Conclusion: The WOQ-9 is a convenient screening tool to aid physicians to detect WO in PD patients, and it is a quick and easy self-administered questionnaire.Keywords: Parkinson's disease, levodopa, wearing-off, questionnaire. RESUMOObjetivo: (1) Verificar se o Questionário de Nove Itens (WOQ-9) para detectar wearing-off (WO) na doença de Parkinson (DP), pela sua capacidade de triagem, seria útil aos neurologistas na identificação de WO; (2) determinar a sensibilidade e especificidade da versão livre em Português Brasileiro do WOQ-9. Método: Ao todo 60 indivíduos com DP compuseram uma amostra obtida por conveniência. Os próprios pacientes responderam ao WOQ-9 antes de suas consultas rotineiras. A detecção de WO pelo WOQ-9 foi comparada com a avaliação neurológica. A significância estatística foi 5%. Resultados: O WOQ-9 apresentou sensibilidade de 100%, especificidade de 10,3%, valores preditivos positivo e negativo de 54,4% e 100% respectivamente. A identificação de WO pelo WOQ-9 foi congruente em 54,5% dos casos com a avaliação neurológica. Conclusão: O WOQ-9 é um método de rastreamento útil para identificar WO em pacientes com DP, e é um questionário de autoavaliação cuja aplicação é fácil e rápida.Palavras-chave: doença de Parkinson, levodopa, wearing-off, questionários.The treatment of Parkinson's disease (PD) remains a major challenge spite of the increasing therapeutic arsenal in recent decades and progressing knowledge of its pathophysiology. Levodopa (LD) remains the most effective and widely prescribed drug in the symptomatic treatment of PD 1 . Currently it is acknowledged that up to 50% of patients have motor fluctuations after two years of the introduction of LD or another dopaminergic agonist (DA) 2,3 . The long-term use of levodopa leads to complications directly related to the duration of the treatment. Such complications include motor symptoms (MS) and non-motor symptoms (NMS). The most frequent motor complications are the motor fluctuations and dyskinesias. Wearing-off (WO) is one subtype of motor fluctuation and occurs over time, when the effectiveness of a dose of dopaminergic agonist tends to wear off earlier than before. For confirmation of this phenomeno...

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Specificity and sensibility of 9-Itens Wearing-off Questionnaire in Brazilian Parkinson disease patient sample

Santos

Chien

Barbosa

2014

Arq. Neuro-Psiquiatr.

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The Neuropsychiatric Fluctuations Scale for Parkinson's Disease: A Pilot Study

Schmitt

Krack

Castrioto

et al. 2018

Movement Disord Clin Pract

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Background Non‐motor fluctuations represent a main source of disability in Parkinson's disease (PD). Among them, neuropsychiatric fluctuations are the most frequent and are often under‐recognized by patients and physicians, partly because specific tools for assessment of neuropsychiatric fluctuations are lacking. Objective To develop a scale for detecting and evaluating the presence and the severity of neuropsychological symptoms during the ON and OFF phases of non‐motor fluctuations. Methods Neuropsychiatric symptoms reported by PD patients in the OFF‐ and the ON‐medication conditions were collected using different neuropsychiatric scales (BDI‐II, BAI, Young, VAS, etc.). Subsequently, tree phases of a pilot study was performed for cognitive pretesting, identification of ambiguous or redundant items (item reduction), and to obtain preliminary data of acceptability of the new scale. In all the three phases, the scale was applied in both the OFF and ON condition during a levodopa challenge. Results Twenty items were selected for the final version of the neuropsychiatric fluctuation scale (NFS): ten items measured the ON neuropsychological symptoms and ten items the OFF neuropsychological manifestations. Each item rated from 0‐3, providing respective subscores from 0 to 30. Conclusions Once validated, our NFS can be used to identify and quantify neuropsychiatric fluctuations during motor fluctuations. The main novelty is that it could be used in acute settings. As such, the NFS can assess the neuropsychiatric state of the patient at the time of examination. The next step will be to validate the NFS to be used in current practice.

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Wearing‐off scales in Parkinson's disease: Critique and recommendations

Antonini¹,

Martinez‐Martín²,

Chaudhuri³

et al. 2011

Movement Disorders

103

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Wearing-off occurs in the majority of patients with Parkinson's disease after a few years of dopaminergic therapy. Because a variety of scales have been used to estimate wearing-off, the Movement Disorder Society commissioned a task force to assess their clinimetric properties. A systematic review was conducted to identify wearing-off scales that have either been validated or used in Parkinson's patients. A scale was designated "Recommended" if it had been used in clinical studies beyond the group that developed it, if it had been specifically used in Parkinson's disease reports, and if clinimetric studies had established that it is valid, reliable, and sensitive. "Suggested" scales met 2 of the above criteria, and those meeting 1 were "Listed." We identified 3 diagnostic and 4 severity rating scales for wearing-off quantification. Two questionnaires met the criteria to be Recommended for diagnostic screening (questionnaires for 19 and 9 items), and 1 was Suggested (questionnaire for 32 items). Only the patient diaries were Recommended to assess wearing-off severity, with the caveat of relatively limited knowledge of validity. Among the other severity assessment tools, the Unified Parkinson Disease Rating Scale version 3 and the version revised from the Movement Disorders Society were classified as Suggested, whereas the Treatment Response Scale was Listed.

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The sensitivity and specificity of the 9-item Wearing-off Questionnaire

Cited by 71 publications

References 9 publications

Specificity and sensibility of 9-Itens Wearing-off Questionnaire in Brazilian Parkinson disease patient sample

Specificity and sensibility of 9-Itens Wearing-off Questionnaire in Brazilian Parkinson disease patient sample

The Neuropsychiatric Fluctuations Scale for Parkinson's Disease: A Pilot Study

Wearing‐off scales in Parkinson's disease: Critique and recommendations

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