The Sensimed Triggerfish contact lens sensor: efficacy, safety, and patient perspectives

Dunbar, Grace E.; Shen, Bailey; Aref, Ahmad A.

doi:10.2147/opth.s109708

Cited by 97 publications

(81 citation statements)

References 20 publications

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“…Previous work has shown that the radius of curvature of the cornea changes as IOP changes [12] [13]. Based on this information, a 250um thick polydimethylsiloxane (PDMS) soft contact lens was manufactured with an embedded 100 um wide by 100 um thick microfluidic channel ( Figure 1).…”

Section: Methodsmentioning

confidence: 99%

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Non-invasive Intraocular pressure monitoring with contact lens

Campigotto

Leahy

Zhao³

et al. 2019

Br J Ophthalmol

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BackgroundGlaucoma is the second leading cause of blindness in the world and the first leading cause of irreversible vision loss. Currently, the primary methodology of testing for the intraocular pressure (IOP) is during clinical office hours, which only provide a limited amount of information on the trends and fluctuations of the IOP. Therefore, a continuous monitoring system is required to properly determine the peaks of pressure and to negate any false results obtained by sparse, clinic hour testing. The objective of this study is to determine the ability of a newly designed contact lens with an embedded microchannel, to accurately measure the fluctuations in the IOP.MethodsExperimentation was completed on fresh enucleated porcine eyes. The contact lens was placed on the porcine eye and utilising a camera the fluid movement, within the microchannel in the contact lens, was recorded. A micro-pressure catheter, threaded into the centre of the vitreous chamber, recorded the true IOP and was compared with the displacement of the indicator fluid within the microchannel.ResultsThe contact lenses showed a consistent linear responsiveness to changes in IOP and robust to the effects of anatomical differences among eyes. The indicator fluid had an average fluid movement of 28 um/mm Hg between all the trials. Additionally, the devices showed the ability to measure both increases and decreases in IOP during cyclical fluctuations.ConclusionThe described inexpensive and non-invasive sensor is able to reliably monitor the IOP changes based on porcine eye model.

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Section: Methodsmentioning

confidence: 99%

“…Recently, a continuous monitoring contact system, the Sensimed Triggerfish contact lens, has been approved for marketing. This device is designed to detect changes in eye shape induced by changes in intraocular pressure, but appears to provide data on relative changes in intraocular pressure rather than absolute intraocular pressure [12].…”

mentioning

confidence: 99%

Non-invasive Intraocular pressure monitoring with contact lens

Campigotto

Leahy

Zhao³

et al. 2019

Br J Ophthalmol

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“…Considering the aforementioned features and relative ease of fitting the sensor, its utilization could bring valuable information into discussion on the ABP and IOP relationship. However, its broad application is currently limited by the high cost, which is estimated at $700 USD per one 24 h measurement [40].…”

Section: Perspectives -24 Hour Ocular Volume Monitoringmentioning

confidence: 99%

Blood pressure and glaucoma: At the crossroads between cardiology and ophthalmology

et al. 2019

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Glaucoma is an optic nerve neuropathy of undetermined cause. Although many mechanisms are thought to be involved in the development and progression of the disease, only an increased intraocular pressure has been established as a clinically significant modifiable risk factor. Nevertheless, up to 40% of patients develop glaucoma without evidence of increased intraocular pressure. Ample evidence suggests that alterations in the control of arterial blood might negatively affect optic nerve function. However, evidence-based guidelines on the management of arterial blood pressure in glaucoma patients are lacking. Regrettably, intraocular pressure is generally not included as a secondary end-point in clinical trials on arterial hypertension. Considering the relative simplicity of intraocular pressure measurements and large number of patients included in hypertension studies, the benefits of including intraocular pressure as a secondary end-point could be of a great value for improving care for glaucoma patients. Therefore, closer collaboration between cardiologists and ophthalmologists is needed.

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“…This device can only measure relative changes rather than determine absolute pressure. 31 There are currently many new intraocular sensor devices in development [32][33][34] and if any of these are proven to be accurate and safe, reliable continuous IOP monitoring for many patients may soon become a reality.…”

Section: Q: What Future Developments Can We Look Forward To In 2018?mentioning

confidence: 99%

Recent Developments in Glaucoma

Lim¹

2017

European Ophthalmic Review

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Glaucoma continues to exert a heavy disability and economic burden and is the most frequent cause of irreversible blindness worldwide. In 2015, 57.5 million people globally were affected by open-angle glaucoma and this is predicted to increase to 65.5 million by 2020. The prevalence of glaucoma increases with age in all populations and generally more men and people of Hispanic and Black race are affected. Effective treatments to lower and maintain intraocular pressure (IOP) and convenient means of continuously monitoring it remain substantial unmet medical needs. In this expert interview Kin Sheng Lim from Guy’s and St Thomas’ Hospitals, London, UK, discusses the new developments to improve this situation and are therefore of great interest to ophthalmologists and to the wider population who are at risk from glaucoma.

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The Sensimed Triggerfish contact lens sensor: efficacy, safety, and patient perspectives

Cited by 97 publications

References 20 publications

Non-invasive Intraocular pressure monitoring with contact lens

Non-invasive Intraocular pressure monitoring with contact lens

Blood pressure and glaucoma: At the crossroads between cardiology and ophthalmology

Recent Developments in Glaucoma

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