The semantic category effect increases with worsening anomia in Alzheimer’s type dementia

Whatmough, Christine; Chertkow, Howard; Murtha, Susan; Templeman, D; Babins, Lennie; Kelner, Nora

doi:10.1016/s0093-934x(02)00524-2

Cited by 67 publications

(47 citation statements)

References 34 publications

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“…Finally, the individual case analyses revealed that nine cases of dissociation on the picture naming task were confirmed on the below ceiling naming-to-definition task (only three cases were not confirmed); the confirmation of dissociation on the latter task is harder to reconcile with a ceiling effect in controls. The low incidence of nonliving dissociations accords with the wider category-specific literature (revealing a ratio of approximately 5:1; Laws, 2005) and recent sudies of larger samples of AD patients, which reveal a very low incidence of nonliving deficits: Garrard et al (1998) found just 3 in 58 (5%), while Whatmough et al (2003) found 4 in 72 (5.5%). Our failure to find this elusive 5% may simply reflect the smaller AD sample size used in the current study.…”

Section: Discussionsupporting

confidence: 84%

A predominance of category deficits for living things in Alzheimer's disease and Lewy body dementia

Laws

Crawford

Gnoato

et al. 2007

J. Inter. Neuropsych. Soc.

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Although semantic memory impairment is well documented in patients with dementia of the Alzheimer's type, questions remain as to whether the deficit extends to other forms of dementia and whether it differentially affects different domains of knowledge. We examined category naming on two tasks (picture naming and naming-to-description) in patients with Alzheimer's disease (AD: n 5 11), Lewy body dementia (DLB: n 5 11) and healthy elderly matched controls (n 5 22). The DLB and AD groups showed significantly worse naming on both tasks, although the AD patients were more impaired than the DLB patients. Like some AD patients, some DLB patients showed evidence of category-specific naming deficits, and strikingly, all 25 significant category dissociations were for living things. The latter finding accords with the preponderance of living deficits previously documented for AD patients, but extends this finding to DLB patients. The implications of this category bias is discussed in relation to relevant models of category specificity. (JINS, 2007, 13, 401-409.)

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Section: Discussionsupporting

confidence: 84%

A predominance of category deficits for living things in Alzheimer's disease and Lewy body dementia

Laws

Crawford

Gnoato

et al. 2007

J. Inter. Neuropsych. Soc.

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“…Semantic deficits have been documented in AD using a variety of standard clinical neuropsychological tests (Huff et al, 1986;Rosser and Hodges, 1994;Hodges and Patterson, 1995;Adlam et al, 2006) and using more specific measures (Chertkow and Bub, 1990;Hodges et al, 1992;Greene and Hodges, 1996;Fung et al, 2001;Thompson et al, 2002;Whatmough et al, 2003;Joubert et al, 2010). Working memory deficits are also frequently reported in AD and involve reduced span for words, digits, letters and spatial locations (Grossi et al, 1993;Belleville et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Early-onset and late-onset Alzheimer's disease are associated with distinct patterns of memory impairment

Joubert

Gour

Guedj

et al. 2016

Cortex

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The goal of this study was to investigate the specific patterns of memory breakdown in patients suffering from early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD). Twenty EOAD patients, twenty LOAD patients, twenty matched younger controls, and twenty matched older controls participated in this study.All participants underwent a detailed neuropsychological assessment, an MRI scan, an FDG-PET scan, and AD patients had biomarkers as supporting evidence of both amyloïdopathy and neuronal injury. Results of the neuropsychological assessment showed that both EOAD and LOAD groups were impaired in the domains of memory, executive functions, language, praxis, and visuoconstructional abilities, when compared to their respective control groups. EOAD and LOAD groups, however, showed distinct patterns of memory impairment. Even though both groups were similarly affected on measures of episodic, short term and working memory, in contrast semantic memory was significantly more impaired in LOAD than in EOAD patients. The EOAD group was not more affected than the LOAD group in any memory domain. EOAD patients, however, showed significantly poorer performance in other cognitive domains including executive functions and visuoconstructional abilities. A more detailed analysis of the pattern of semantic memory performance among patient groups revealed that the LOAD was more profoundly impaired, in tasks of both spontaneous recall and semantic recognition.Voxel-Based Morphometry (VBM) analyses showed that impaired semantic performance in patients was associated with reduced gray matter volume in the anterior temporal lobe region, while PET-FDG analyses revealed that poorer semantic performance was associated with greater hypometabolism in the left temporoparietal region, both areas reflecting key regions of the semantic network. Results of this study indicate that EOAD and LOAD patients present with distinct patterns of memory impairment, and that a genuine semantic impairment may represent one of the clinical hallmarks of LOAD.

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“…Literature review revealed that despite the word-finding impairment in the elderly, patients with AD had lower ability to efficiently perform the naming process, compared with healthy individuals (4,6,7,23). Moreover, studies show that lack of proper naming performance could be detected at early stages or unexpectedly during the primary AD stages.…”

Section: Discussionmentioning

confidence: 99%

“…According to the studies, there is a growing language-impairment in patients with AD (1). The main compromised language aspects are being verbally fluent (3,4), naming of objects (5,6), discourse processing (7), and semantic comprehension (2,8). According to previous investigations, most impairments are observed at the semantics level of MCI patients (9).…”

Section: Introductionmentioning

confidence: 99%

Picture-Naming Performance in Persian-Speaking Patients with Mild Cognitive Impairment and Alzheimer’s Disease

et al. 2018

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Background: Most studies show that picture-naming test is the best task to evaluate the underlined cognitive and language function in the patients with dementia. Naming performance is the most evident linguistic symptom, which starts in the initial phase of the mild cognitive impairment (MCI) and Alzheimer's disease (AD). Objectives: The current study aimed at determining the picture-naming performance level of Persian-speaking patients with MCI and AD compared with normal peers using naming subtests of Barnes language assessment (BLA). Methods: In total, 90 subjects were selected through self-report; some relevant tests including mini-mental status examination (MMSE) and functional assessment staging (FAST) scale, as well as experts comments were employed; subjects were divided into three groups of MCI, AD, and normal control (NC) (30 cases per group). Picture-naming performance of patients in the MCI and AD groups was assessed and compared with that of the NC group using the naming subtest of the BLA. Results: In the picture-naming test of BLA, the AD group performed worse than the NC and MCI groups (P < 0.001). Moreover, a significant difference was observed between the NC and MCI groups. While the MCI group performed worse than the NC (P < 0.001), it acted better than the AD group (P < 0.001). Conclusions: According to the results of the current study, picture naming test was a useful cognitive-linguistic task, which can accurately differentiate the three study groups, especially MCI from normal subjects, despite its quick and simple application.

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The semantic category effect increases with worsening anomia in Alzheimer’s type dementia

Cited by 67 publications

References 34 publications

A predominance of category deficits for living things in Alzheimer's disease and Lewy body dementia

A predominance of category deficits for living things in Alzheimer's disease and Lewy body dementia

Early-onset and late-onset Alzheimer's disease are associated with distinct patterns of memory impairment

Picture-Naming Performance in Persian-Speaking Patients with Mild Cognitive Impairment and Alzheimer’s Disease

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