The self-diffusion of macromolecules in binary blends of poly(ethylene glycol)

Aslanyan, Irina Yu.; Skirda, V. D.; Zaripov, A. M.

doi:10.1002/(sici)1099-1581(199903)10:3<157::aid-pat857>3.0.co;2-v

Cited by 7 publications

(1 citation statement)

References 5 publications

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“…In addition, because α-casein does not form a stable and well-folded structure, − the influence of internal dynamics on its diffusion coefficient could be expected. Previously, it has been shown that this contribution is not significant for the construction of master curves for the concentration dependence of diffusion coefficients of globular proteins and poly(ethylene glycol) homopolymers but becomes important in the case flexible polymers and poly(allylcarbosilane) dendrimers . On the basis of experimental data obtained for 17 different polymer–solvent systems, it was shown that the contribution of internal dynamics to the diffusion coefficient can be excluded by dividing the polymer diffusion coefficient by the dimensionless normalizing function L (φ) obtained from the concentration dependences of the polymer T 1 and T 2 relaxation times .…”

Section: Resultsmentioning

confidence: 99%

Effect of Intrinsic Disorder and Self-Association on the Translational Diffusion of Proteins: The Case of α-Casein

Melnikova

Skirda

Nesmelova³

2017

J. Phys. Chem. B

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Translational diffusion is the major mode of macromolecular transport in leaving organisms, and therefore it is vital to many biological and biotechnological processes. Although translational diffusion of proteins has received considerable theoretical and experimental scrutiny, much of that attention has been directed toward the description of globular proteins. The translational diffusion of intrinsically disordered proteins (IDPs), however, is much less studied. Here, we use a pulsed-gradient nuclear magnetic resonance technique (PFG NMR) to investigate the translational diffusion of a disordered protein in a wide range of concentrations using α-casein that belongs to the class of natively disordered proteins as an example.

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Section: Resultsmentioning

confidence: 99%

Effect of Intrinsic Disorder and Self-Association on the Translational Diffusion of Proteins: The Case of α-Casein

Melnikova

Skirda

Nesmelova³

2017

J. Phys. Chem. B

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Impact of Molecular Weight on Miscibility and Interdiffusion between Poly(N‐vinyl pyrrolidone) and Poly(ethylene glycol)

Bairamov

Чалых

Feldstein

et al. 2002

Macro Chemistry & Physics

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Miscibility and mutual diffusion between poly(N‐vinylpyrrolidone) (PVP) and short‐chain poly(ethylene glycol)s (PEGs) of different molecular weight were studied by optical wedge microinterferometry (WMI). The PVP Mn varied from 1 300 to 360 000 g · mol−1, whereas that of PEG ranged from 200 to 6 000 g · mol−1. Photographs of interference patterns measured at λ = 546 nm with an optical microscope were used to observe the PVP/PEG interface. PVP blends with short‐chain PEG fractions, ranging in molecular weight from 200 to 1 500 g · mol−1, were found to be fully miscible above the temperatures of PEG fusion, whereas an increase in the molecular weight of up to 3 000 g · mol−1 renders the two polymers completely immiscible. Successive photographs of interference patterns (the interferogram of the contact interface between PEG6000 (left) and PVP is shown in the Figure) were used to determine composition‐distance profiles and to calculate the composition‐dependent mutual diffusion coefficient in miscible PVP/PEG blends. It was shown that the effects of PVP molecular weight are in reasonable agreement with those observed for other compatible polymer systems. In contrast to PVP behavior, the effects of PEG molecular weight indicate appreciable contribution of hydrogen bonding of terminal hydroxyl groups in short PEG chains to the miscibility and diffusivity behavior in the PVP/PEG system. The difference in the effects of PEG and PVP chain lengths is ascribed to hydrogen bonding between PEG terminal hydroxyl groups with carbonyl side groups of repeat units in PVP macromolecules and ether oxygens in the PEG chains. Interferogram of the contact interface between PEG 6000 (left) and PVP. Magnification: 60‐fold.magnified imageInterferogram of the contact interface between PEG 6000 (left) and PVP. Magnification: 60‐fold.

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Self-diffusion and nuclear magnetic relaxation of dendritic macromolecules in solutions

et al. 2003

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The self-diffusion and nuclear magnetic relaxation of poly(butylcarbosilane) and poly(allylcarbosilane) dendrimers disso[ved in deuterated chioroform and poly(amidoamine) dendrimers with hydroxyl surface groups in solutions with methanol have been studied. The diffusion rates (D) have been measured by the pulsed-field-gradient nuclear magnetic resonance. It is shown that experimental concentration dependences D((o) obtained for macromolecules in the dend¡ systems studied can be reduced to a unified view, and thus, the generalized concentration dependence of the normalized diffusion rates of dendrimers can be obtained. In the macromolecular volume concentration range from 0.01 up to 0.55, the generalized dependence of the normalized diffusion rates for dend¡ coincides with the analogous dependence for globular proteins in aqueous solutions; the last result suggests that self-diffusion features of dendrimers and globular proteins are in general similar. [t is also shown that the experimental data obtained permit one to characterize the changes of the own monoroer density of dendrimers depending on their molecular weight and, asa consequence, to make a conclusion about the swelling of dendritic macromolecules in the solutions studied.

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The self-diffusion of macromolecules in binary blends of poly(ethylene glycol)

Cited by 7 publications

References 5 publications

Effect of Intrinsic Disorder and Self-Association on the Translational Diffusion of Proteins: The Case of α-Casein

Effect of Intrinsic Disorder and Self-Association on the Translational Diffusion of Proteins: The Case of α-Casein

Impact of Molecular Weight on Miscibility and Interdiffusion between Poly(N‐vinyl pyrrolidone) and Poly(ethylene glycol)

Self-diffusion and nuclear magnetic relaxation of dendritic macromolecules in solutions

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