The Selenylation Modification of Epimedium Polysaccharide and Isatis Root Polysaccharide and the Immune-enhancing Activity Comparison of Their Modifiers

Li, Xiuping; Hou, Ranran; Yue, Chanjuan; Liu, Jie; Gao, Zhenzhen; Chen, Jin; Lu, Yu; Wang, Deyun; Liu, Cui; Hu, Yuanliang

doi:10.1007/s12011-015-0511-4

Cited by 25 publications

(7 citation statements)

References 16 publications

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“…The polysaccharide iron (III) complex promotes the proliferation of lymphocytes and enhances the activity of macrophages in mice, as well could also be used as an iron enhancer to assist in the treatment of iron deficiency anemia (Cui et al., 2017 ; Gao et al., 2019 ; Liu, Yin, et al., 2019 ; Liu, Liu, et al., 2019 ). Polysaccharide selenium can be used as a potential antioxidant, selenium supplement, and immune enhancer in the treatment of cancer and diabetes (Li et al., 2015 ; Pang & Chin, 2019 ; Wang et al., 2018 ; Yang & Zhang, 2016 ). Polysaccharide zinc could promote the apoptosis of cancer cells by activating the expression of caspase‐3, caspase‐8, and caspase‐9, inducing chromatin condensation, mitochondrial dysfunction, and excessive production of ROS.…”

Section: Results and Analysismentioning

confidence: 99%

Structural modification and biological activities of carboxymethyl Pachymaran

Yan

Yuan

et al. 2021

Food Science & Nutrition

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Section: Results and Analysismentioning

confidence: 99%

Structural modification and biological activities of carboxymethyl Pachymaran

Yan

Yuan

et al. 2021

Food Science & Nutrition

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“…[270], Hericium erinaceus [271], Glycyrrhiza uralensis [272], Epimedium sp. [273], Isatis indigotica root [273], Schisandra chinensis [243], Capparis spionosa [274], Cynomorium songaricum [256], Murus alba [275], Castanea mollissima [276], Rhizobium sp. [277], Artemisia sphaerocephala [244], Potentilla anserina [278], Lactococcus lactis subsp.…”

Section: Se-esters-selenites and Diselenites Of Polysaccharidesmentioning

confidence: 99%

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

2021

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Selenosugars are a group of sugar derivatives of great structural diversity (e.g., molar masses, selenium oxidation state, and selenium binding), obtained as a result of biosynthesis, chemical modification of natural compounds, or chemical synthesis. Seleno-monosaccharides and disaccharides are known to be non-toxic products of the natural metabolism of selenium compounds in mammals. In the case of the selenium-containing polysaccharides of natural origin, their formation is also postulated as a form of detoxification of excess selenium in microorganisms, mushroom, and plants. The valency of selenium in selenium-containing polysaccharides can be: 0 (encapsulated nano-selenium), IV (selenites of polysaccharides), or II (selenoglycosides or selenium built into the sugar ring to replace oxygen). The great interest in Se-polysaccharides results from the expected synergy between selenium and polysaccharides. Several plant- and mushroom-derived polysaccharides are potent macromolecules with antitumor, immunomodulatory, antioxidant, and other biological properties. Selenium, a trace element of fundamental importance to human health, has been shown to possess several analogous functions. The mechanism by which selenium exerts anticancer and immunomodulatory activity differs from that of polysaccharide fractions, but a similar pharmacological effect suggests a possible synergy of these two agents. Various functions of Se-polysaccharides have been explored, including antitumor, immune-enhancement, antioxidant, antidiabetic, anti-inflammatory, hepatoprotective, and neuroprotective activities. Due to being non-toxic or much less toxic than inorganic selenium compounds, Se-polysaccharides are potential dietary supplements that could be used, e.g., in chemoprevention.

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“…This highlights the interesting paradox of Se regulating oxidation status (redox tone) in either direction e.g., reducing oxidation status or triggering oxidation. Selenylation of plant polysaccharides, known to be immune-stimulatory, were found to have enhanced immune activity in vitro (peripheral lymphocytes) and in vivo (chickens) compared to their un-selenated forms (Li et al, 2016 ), whilst Se-enriched Lactobacillus brevis induced interferon γ and interleukin 17 secretion and increased natural killer cell activity in mice compared to L. brevis alone (Yazdi et al, 2012 ). Both studies indicate the Se predominate effect may be immune enhancement rather than regulation.…”

Section: Selenoglucosinolates For Human Nutritionmentioning

confidence: 99%

Mechanisms of Selenium Enrichment and Measurement in Brassicaceous Vegetables, and Their Application to Human Health

Wiesner-Reinhold¹,

Schreiner²,

Baldermann³

et al. 2017

Front. Plant Sci.

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Selenium (Se) is an essential micronutrient for human health. Se deficiency affects hundreds of millions of people worldwide, particularly in developing countries, and there is increasing awareness that suboptimal supply of Se can also negatively affect human health. Selenium enters the diet primarily through the ingestion of plant and animal products. Although, plants are not dependent on Se they take it up from the soil through the sulphur (S) uptake and assimilation pathways. Therefore, geographic differences in the availability of soil Se and agricultural practices have a profound influence on the Se content of many foods, and there are increasing efforts to biofortify crop plants with Se. Plants from the Brassicales are of particular interest as they accumulate and synthesize Se into forms with additional health benefits, such as methylselenocysteine (MeSeCys). The Brassicaceae are also well-known to produce the glucosinolates; S-containing compounds with demonstrated human health value. Furthermore, the recent discovery of the selenoglucosinolates in the Brassicaceae raises questions regarding their potential bioefficacy. In this review we focus on Se uptake and metabolism in the Brassicaceae in the context of human health, particularly cancer prevention and immunity. We investigate the close relationship between Se and S metabolism in this plant family, with particular emphasis on the selenoglucosinolates, and consider the methodologies available for identifying and quantifying further novel Se-containing compounds in plants. Finally, we summarize the research of multiple groups investigating biofortification of the Brassicaceae and discuss which approaches might be most successful for supplying Se deficient populations in the future.

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The Selenylation Modification of Epimedium Polysaccharide and Isatis Root Polysaccharide and the Immune-enhancing Activity Comparison of Their Modifiers

Cited by 25 publications

References 16 publications

Structural modification and biological activities of carboxymethyl Pachymaran

Structural modification and biological activities of carboxymethyl Pachymaran

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

Mechanisms of Selenium Enrichment and Measurement in Brassicaceous Vegetables, and Their Application to Human Health

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