The selenocompound 1-methyl-3-(phenylselanyl)-1H-indole attenuates depression-like behavior, oxidative stress, and neuroinflammation in streptozotocin-treated mice

Bampi, Suely Ribeiro; Casaril, Angela Maria; Fronza, Mariana G.; Domingues, Micaela; Vieira, Beatriz; Begnini, Karine R.; Seixas, Fabiana Kömmling; Collares, Tiago; Lenardão, Eder J.; Savegnago, Lucielli

doi:10.1016/j.brainresbull.2020.05.008

Cited by 21 publications

(18 citation statements)

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“…SOD, GSH and CAT are the frontline enzymes that initiates cellular protective effects against ROS and oxidative stress element [ 7 , 36 , 37 ]. In the results presented here, SOD, GSH and CAT activities were significantly decreased, and the MDA level increased significantly in brain structures of the DMG group, which corroborates with previous reports [ 8 , 26 , 38 ]. Earlier studies have suggested that antidepressant agents could ameliorate oxidative stress, upregulate antioxidant defense, thus restoring redox homeostasis, leading to the reversal of DM-induced anxiety and depressive-like behaviors [ 25 , 38 , 39 ].…”

Section: Discussionsupporting

confidence: 93%

“…The results from this study revealed that DM led to characteristic anxiety and depressive-like behaviors, as indicated by the increase in immobility duration (FST), decrease in entries and time spent in the open arms (EPMT) as well as reduction in the number of crossing and rearing (OFT), which were in corroboration with previous studies on DM-induced anxiety and depression [ 8 , 26 , 31 , 32 ]. Metabolic disorders, including diabetes and obesity, have been prominently associated a number of psychological problems particularly major depressive disorders and anxiety, and hyperglycemia is a prevalent factor that can modulate the onset, progression and deterioration of depression and anxiety [ 33 ].…”

Section: Discussionsupporting

confidence: 91%

“…Anxiety and depression constitute a relatively high social hazard and high suicide rate [ 24 ] and the incidence of these two psychiatric disorders are 2–3 times higher in diabetic patients when compared to normal people [ 11 ]. One of the most sought-after therapeutic approach for the treatment of hyperglycemia and its resulting complications is to keep the blood glucose level at bay, which may subsequently limit the generation of reactive oxygen species and oxidative stress, a major factor implicated in diabetic complications, including DM-induced anxiety and depression [ 25 , 26 ]. Although antidiabetic medicines such as metformin and glibenclamide have been widely successful in the control of blood glucose level, several side effects have limited their success.…”

Section: Discussionmentioning

confidence: 99%

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LC/ESI/TOF-MS Characterization, Anxiolytic and Antidepressant-like Effects of Mitragyna speciosa Korth Extract in Diabetic Rats

2022

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In this study, the attenuative effects of the hydro-alcoholic extract from Mitragyna speciosa (MSE) against diabetes-induced anxiety and depression-like behaviors were examined. In addition, UPLC/ESI/TOF-MS analysis was performed to identify the phytochemical nature of MSE. DM was induced using a combination of high fructose/streptozotocin, and the diabetic rats were treated with MSE (50 and 200 mg/kg) for 5 weeks. After treatment, the animals were subjected to a forced swim test, open field test and elevated plus-maze tests. Additionally, proinflammatory cytokines and oxidative stress parameters were evaluated in the brain tissues of the rats. UPLC/ESI/TOF-MS analysis revealed that MSE is abundantly rich in polyphenolic constituents, notably flavonoid and phenolic glycosides. Behavioral tests and biochemical analyses indicated that diabetic rats showed significantly increased anxiety and depressive-like behavioral deficits, brain oxidative stress and pro-inflammatory cytokines levels (IL-1β, IL-6 and TNF-α). Treatment with MSE (50 and 200 mg/kg) significantly attenuated increased blood glucose level, depressive and anxiety-like behaviors in diabetic rats. Additionally, the antioxidant enzymes activities were markedly increased in MSE-treated animals, while TNF-α, IL-1β and IL-6 cytokines were notably suppressed. Taken together, these results suggested that MSE has potentials as antidepressant and anxiolytic-like effects and improves the brain oxido-inflammatory status in diabetic rats.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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LC/ESI/TOF-MS Characterization, Anxiolytic and Antidepressant-like Effects of Mitragyna speciosa Korth Extract in Diabetic Rats

2022

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“…Differently from other metals, selenium incorporates into selenoproteins (glutathione per-oxidases and thioredoxin reductases) and protects from lipoperoxidation and oxidative cell damage (the glutathione antioxidant system is implicated in the pathophysiology of mood disorders) ( 31 ). Consistently, the selenocompound 1-methyl-3-(phenylselany1)-1H-indole attenuates depression-like behavior, oxidative stress, and neuroinflammation in streptozotocin-treated mice ( 32 ). Moreover, manganese is an important component of MnSOD, an antioxidant mitochondrial metalloenzyme that protects cells from oxidative stress ( 12 , 33 ).…”

Section: Discussionmentioning

confidence: 89%

Associations of Dietary Copper, Selenium, and Manganese Intake With Depression: A Meta-Analysis of Observational Studies

Ding

Zhang

2022

Front. Nutr.

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ObjectiveTo comprehensively summarize the evidence on the associations of dietary copper, selenium, and manganese intake with depression based on a meta-analysis of observational studies.MethodsThe electronic database of PubMed, Web of Science, and Embase were searched up to January 7, 2022, for observational studies on the associations of dietary copper, selenium and manganese intake with depression (no restriction was set for the initiate time). The pooled relative risk (RR) of depression for the highest vs. lowest dietary copper, selenium, and manganese intake category were calculated.ResultsA total of 11 observational studies (61,430 participants) were identified as meeting the inclusion criteria. Specifically, five studies were related to the dietary copper intake. The overall multi-variable adjusted RR demonstrated that dietary copper intake was inversely associated with depression (RR = 0.63, 95% CI: 0.52–0.76; P < 0.001; I2 = 2.4%). With regard to the dietary selenium intake, six studies were identified for meta-analysis. The overall multi-variable adjusted RR showed that dietary selenium intake was also negatively associated with depression (RR = 0.63, 95% CI: 0.54–0.74; P < 0.001; I2 = 37.8%). In addition, four studies were specified for the dietary manganese intake, and the overall multi-variable adjusted RR indicated a negative relationship between dietary manganese intake and depression (RR = 0.71, 95% CI: 0.58–0.86; P < 0.001; I2 = 0.0%).ConclusionsOur results suggest a negative relationship between dietary copper, selenium and manganese intake and depression, respectively. However, due to the limited prospective evidence, our results are restricted to cross-sectional design that precludes causal relationships. More well-designed prospective cohort studies are still needed.

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“…One of the direct downstream metabolites of indoles is the uremic toxin indoxyl sulfate which is low in animal models of depression ( Zheng et al., 2010 ) and MDD patients ( Chen et al., 2017 ). Indoles are just beginning to be studied in the context of depression, but one of the first promising studies shows that 1-methyl-3-(phenylselanyl)-1 H -indole reverses stress induced depressive-like behavior in mice ( Bampi et al., 2020 ). Indoles derived from bacteria and plants are potential novel targets for antidepressant therapy and are in need of further investigation ( Hamid et al., 2017 ).…”

Section: Indolesmentioning

confidence: 99%

Microbial metabolites and immune regulation: New targets for major depressive disorder

Merchak

Gaultier

2020

Brain, Behavior, & Immunity - Health

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Treatments for depression and mood disorders have been singularly targeted at the brain without consideration for the context of the rest of the body. As evidence mounts for a role of autoimmunity and inflammation as risk factors and contributors to mood disorders, attention has shifted to one of the primary immunoregulatory organs in the body--the gut. Gut-brain interactions have been established and correlative links between the microbiome and mood have been examined, but with novel tools and a base of understanding, focus shifts to the mechanisms of these communications. In this review, we examine how the small molecules produced by metabolic processes of bacteria in the gut influence the host immune system. The gaps in knowledge discussed here include the under characterized diversity of small molecules crossing the gut walls, as well as the need to close the logical loop connecting the microbiome to the immune system, and the immune system to behavior and mood. As we move past the dawn of this field, more precise understanding using novel tools and techniques will help move toward a more informed and systematic process for clinically evaluating the efficacy of probiotics and bacterially derived compounds as antidepressants and mood regulators.

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The selenocompound 1-methyl-3-(phenylselanyl)-1H-indole attenuates depression-like behavior, oxidative stress, and neuroinflammation in streptozotocin-treated mice

Cited by 21 publications

References 39 publications

LC/ESI/TOF-MS Characterization, Anxiolytic and Antidepressant-like Effects of Mitragyna speciosa Korth Extract in Diabetic Rats

LC/ESI/TOF-MS Characterization, Anxiolytic and Antidepressant-like Effects of Mitragyna speciosa Korth Extract in Diabetic Rats

Associations of Dietary Copper, Selenium, and Manganese Intake With Depression: A Meta-Analysis of Observational Studies

Microbial metabolites and immune regulation: New targets for major depressive disorder

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