The selectivity of artemisinin-based drugs on human lung normal and cancer cells

Li, Xinyang; Gu, Shiyan; Sun, Donglei; Dai, Huangmei; Chen, Hongyu; Zhang, Zunzhen

doi:10.1016/j.etap.2017.12.004

Cited by 28 publications

(16 citation statements)

References 37 publications

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“…In 2015, the discovery of artemisinin earned China its first Nobel Prize winner 59 . It has been reported that artemisinin‐based drugs, such as dihydroartemisinin, artemether, artemisinin, and artesunate, are highly effective active antimalarial drugs that also exert effective anticancer activities against hematological tumors and somatic tumors, and selective cytotoxicity toward malignant cells 60 . Therefore, they have become research hotspots.…”

Section: Antineoplastic Drugs Classified By Sourcementioning

confidence: 99%

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Perspectives and controversies regarding the use of natural products for the treatment of lung cancer

2021

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Section: Antineoplastic Drugs Classified By Sourcementioning

confidence: 99%

“…In A549 cells, artemisinin can significantly induce apoptosis through reactive oxygen species‐mediated amplification of the activation loop between caspase‐3, caspase‐8, and caspase‐9 131 . Besides, Artesunate may play a cytotoxic role in A549 cells and normal HBE cells through ROS‐mediated DNA damage 60 …”

Section: Anti‐tumor Mechanismmentioning

confidence: 99%

Perspectives and controversies regarding the use of natural products for the treatment of lung cancer

2021

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“…In addition, artemisinin possesses various biological and pharmacological properties such as anti-schistosomiasis, antivirus, and anticancer (Saeed et al, 2016; Efferth, 2018; Zhang Y. et al, 2018). Artemisinin exhibited the ability for selectively inhibiting cancer cells but only minimal cytotoxicity to normal cells (Li X. et al, 2018). Most notably, DHA, a derivative of artemisinin with better water solubility, has shown potent effects on cell growth inhibition and apoptosis induction by significantly inhibiting Jak2/STAT3 signaling activation and downstream target proteins in human head and neck cancer FaDu, liver cancer Hep-G2, colon cancer HCT-116, and tongue cancer Cal-27 cells (Jia et al, 2016; Wang D. et al, 2017).…”

Section: Anticancer Tcms Through Targeting Jak-stat3 Signal Pathwaymentioning

confidence: 99%

Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines

Lai

Zhang

et al. 2019

Front. Pharmacol.

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Cancer is a leading cause of morbidity and mortality worldwide. Apoptosis is a process of programmed cell death and it plays a vital role in human development and tissue homeostasis. Mounting evidence indicates that apoptosis is closely related to the survival of cancer and it has emerged as a key target for the discovery and development of novel anticancer drugs. Various studies indicate that targeting the apoptotic signaling pathway by anticancer drugs is an important mechanism in cancer therapy. Therefore, numerous novel anticancer agents have been discovered and developed from traditional Chinese medicines (TCMs) by targeting the cellular apoptotic pathway of cancer cells and shown clinically beneficial effects in cancer therapy. This review aims to provide a comprehensive discussion for the role, pharmacology, related biology, and possible mechanism(s) of a number of important anticancer TCMs and their derivatives mainly targeting the cellular apoptotic pathway. It may have important clinical implications in cancer therapy.

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“…Moreover, its five-year survival rate remained at 15% because of the metastasis of the tumor cells. Clinical trials together with in vivo and in vitro experiments elucidated that artemisinin can inhibit and kill lung cancer cells [ 87 – 90 ] (Table 3 ).…”

Section: Antitumor Activity Of Artemisininmentioning

confidence: 99%

“…Studies demonstrated that the IC 50 values of artemisinin and artesunate were 769.60 and 153.54 μM on A549 cell line [ 90 ]. AS is more potent than ART.…”

Section: Antitumor Activity Of Artemisininmentioning

confidence: 99%

Antitumor Research on Artemisinin and Its Bioactive Derivatives

Zhang

et al. 2018

Nat. Prod. Bioprospect.

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Cancer is the leading cause of human death which seriously threatens human life. The antimalarial drug artemisinin and its derivatives have been discovered with considerable anticancer properties. Simultaneously, a variety of target-selective artemisinin-related compounds with high efficiency have been discovered. Many researches indicated that artemisinin-related compounds have cytotoxic effects against a variety of cancer cells through pleiotropic effects, including inhibiting the proliferation of tumor cells, promoting apoptosis, inducing cell cycle arrest, disrupting cancer invasion and metastasis, preventing angiogenesis, mediating the tumor-related signaling pathways, and regulating tumor microenvironment. More importantly, artemisinins demonstrated minor side effects to normal cells and manifested the ability to overcome multidrug-resistance which is widely observed in cancer patients. Therefore, we concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years. It is our hope that this review could be helpful for further exploration of novel artemisinin-related antitumor agents.Graphical Abstract

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The selectivity of artemisinin-based drugs on human lung normal and cancer cells

Cited by 28 publications

References 37 publications

Perspectives and controversies regarding the use of natural products for the treatment of lung cancer

Perspectives and controversies regarding the use of natural products for the treatment of lung cancer

Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines

Antitumor Research on Artemisinin and Its Bioactive Derivatives

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