The Selective Cytotoxicity of Quercus Brantii Lindl. Galls on A375 and SK-MEL-3 Human Malignant Melanoma Cell Lines

Yosefsani, Bahareh Sadat; Mohajer, Kamyar; Qobadi, Ali; Shirani, Kobra; Pourahmad, Jalal

doi:10.31557/apjcp.2023.24.7.2383

Cited by 2 publications

(2 citation statements)

References 32 publications

(40 reference statements)

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“…A recent survey also explored the cytotoxic effects of galls of Q. brantii. The results showed that the extract at a concentration of 0.05 mg/mL significantly (p < 0.001) increased cytotoxicity, ROS formation, lipid peroxidation, and cytochrome-c release in A375 and SK-MEL-3 melanoma versus AGO-1522 normal human fibroblast cell lines [108].…”

Section: Anticancer Activitymentioning

confidence: 95%

Phytochemical Profiling and Biological Activities of Quercus sp. Galls (Oak Galls): A Systematic Review of Studies Published in the Last 5 Years

Banc,

Rusu,

Filip

et al. 2023

Plants

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Quercus species have been widely used in traditional medicine, and recently, researchers’ attention has focused on galls of the genus Quercus as a source of health-promoting phytochemicals. This review presents a summary of the most recent findings on the phytochemistry and bioactivity of oak galls, following the screening of scientific papers published in two relevant databases, PubMed and Embase, between January 2018 and June 2023. The oak galls are rich in active compounds, mostly gallotannins and phenolic acids. Due to these secondary metabolites, the reviewed studies have demonstrated a wide range of biological activities, including antioxidant and anti-inflammatory actions, antimicrobial properties, tissue-protective effects, and antitumor, anti-aging, and hypoglycemic potential. Thus, oak galls are a promising natural matrix, to be considered in obtaining pharmaceutical and cosmetic preparations used in anti-aging strategies and, together with medications, in the management of age-related diseases. In further evaluations, the valuable functional properties of oak galls, reported mostly in preclinical studies, should be confirmed with clinical studies that would also take into account the potential health risks of their use.

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Section: Anticancer Activitymentioning

confidence: 95%

Phytochemical Profiling and Biological Activities of Quercus sp. Galls (Oak Galls): A Systematic Review of Studies Published in the Last 5 Years

Banc,

Rusu,

Filip

et al. 2023

Plants

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“…Brains were removed after decapitation, and striatum tissue was dissected on ice immediately. The striatum was homogenized for 2 min at 4°C in 1.15% potassium chloride (KCl) to determine the levels of the measurement of malondialdehyde (MDA) (an end-product generated by the decomposition of arachidonic acid and larger PUFAs) described previously (15).…”

Section: Measurement Of Malondialdehyde In the Striatum Tissuementioning

confidence: 99%

Castor Oil: A Natural Remedy with Promising Potential for Parkinson's Disease Prevention

Yousefsani,

Ghobadi,

Dadmehr

et al. 2024

Jundishapur J Nat Pharm Prod

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Background: Ricinus communis L, commonly known as the castor oil plant, is a valuable traditional medicine that has been used for thousands of years around the world. The plant contains a diverse range of phytochemicals with various medicinal properties, including anti-oxidant, anti-cancer, anti-inflammatory, central analgesic, anti-diabetic, anti-microbial, anti-viral, and wound healing activities. Its many beneficial compounds make it a valuable natural remedy for numerous health conditions. Objectives: The present study investigated the preventive effect of castor oil on malathion-induced Parkinson's disease (PD)-like behaviors in rats. Methods: Rats were divided into 8 groups: control (normal saline), malathion (100 mg/kg/day, intraperitoneal injection (IP)), castor oil (0.05, 0.1, or 0.5 mL/kg/day, orally) plus malathion, levodopa (10 mg/kg/day, IP) plus malathion, castor oil (0.5 mg/kg/day, orally), and polyethylene glycol (PEG) (vehicle of levodopa) groups. All treatments were administered for 28 days, after which neurobehavioral tests such as open field, rotarod, and catalepsy were performed. The activity of acetylcholinesterase (AChE) in serum and the levels of malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor α (TNFα), and interleukin (IL)-6 in the striatum were measured at the end of the treatment period to assess the potential effects of castor oil. Results: The finding of this study indicated that malathion-induced neurobehavioral toxicity was together with the increase of MDA, TNFα, and IL-6 levels, a decrease of GSH, and AChE activity that was reversed by treatment with castor oil. Conclusions: Overall, these results suggest that castor oil may have potential therapeutic effects for PD by improving antioxidant status and reducing oxidative stress and inflammation, which are both factors that can contribute to the toxicity of pesticides like malathion. However, more research is needed to fully understand the potential protective effects of castor oil in this context.

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The Selective Cytotoxicity of Quercus Brantii Lindl. Galls on A375 and SK-MEL-3 Human Malignant Melanoma Cell Lines

Cited by 2 publications

References 32 publications

Phytochemical Profiling and Biological Activities of Quercus sp. Galls (Oak Galls): A Systematic Review of Studies Published in the Last 5 Years

Phytochemical Profiling and Biological Activities of Quercus sp. Galls (Oak Galls): A Systematic Review of Studies Published in the Last 5 Years

Castor Oil: A Natural Remedy with Promising Potential for Parkinson's Disease Prevention

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