The Selective Capsaicin Antagonist Capsazepine Abolishes the Antinociceptive Action of Eugenol and Guaiacol

Ohkubo, Tsuyako; Shibata, Manabu

doi:10.1177/00220345970760040501

Cited by 91 publications

(51 citation statements)

References 10 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hot-plate test, Tail-flick test and the acetic acid induced writhing test and eugenol had a significant effect (p = 0.002) in all the three models. This effect is in accordance with previous studies, [4][5] however, this study differs from the earlier studies [22][23] primarily with respect to the route of administration, the dose employed and the source of eugenol. From this study, we can say that eugenol alleviates pain of both central as well as peripheral origin.…”

Section: Effect Of Eugenol On Motor Co-ordinationsupporting

confidence: 91%

Experimental study of various central nervous system effects of eugenol in mice and rats

2012

View full text Add to dashboard Cite

Background: Eugenol is an essential component of many medicinal herbs. It is a member of the allylbenzene class of chemical compounds. Since years, it is being used in dental practice to relieve pain arising from pulpitis and dentinal hypersensitivity. There are few reports of anticonvulsant effect but further effects are less reported. Lack of comprehensive studies and data of eugenol on the central nervous system effects in animal models thus necessitates further research activities. Objective: To observe and evaluate various neuropharmacological effects like antinociceptive effect, anticonvulsant effect, effect on motor co-ordination, pentobarbital induced sleeping time and anxiolytic effect of eugenol in mice and rats. Methods: It was a quantitative experimental study done in the laboratory setting of the department of Clinical Pharmacology and Therapeutics. For each test, respective animal models were used. Animals were divided into three groups of six each, group I as control, group II as standard control and group III as test group. Results: Significant effects were observed in analgesic, anticonvulsant and sedative model whereas no significant effect as compared to control was observed in test of motor co-ordination and in behavioral models. Conclusion: This study shows eugenol to possess analgesic, anticonvulsant and sedative effect whereas it didn't have any effect on models of anxiety. Various target sites have been implicated but this study doesn't conclude a plausible mechanism behind all these observed effects.

show abstract

Section: Effect Of Eugenol On Motor Co-ordinationsupporting

confidence: 91%

Experimental study of various central nervous system effects of eugenol in mice and rats

2012

View full text Add to dashboard Cite

show abstract

“…Eugenol has also shown anti-inflammatory, antibacterial, anesthetic, and neuroprotective effects [6][7][8]. It has antioxidant activity [9][10][11][12] and antigenotoxic and anticarcinogenic potential [13,14].…”

Section: Doi: 101159/000488907mentioning

confidence: 99%

Topical Eugenol Successfully Treats Experimental <b><i>Candida albicans</i></b>-Induced Keratitis

Hassan¹,

Geniady²,

Abdelwahab³

et al. 2018

Ophthalmic Res

View full text Add to dashboard Cite

Purpose: To determine the efficacy of eugenol for the treatment of Candida keratitis in an experimental model. Methods: The in vitro antifungal activity of eugenol and fluconazole was tested against C. albicans strains via the microbroth dilution method. An experimental model of Candida albicans keratitis was used. Rabbits were classified into those that received no treatment (control; group 1) and those that started eugenol treatment immediately (group 2) or after 4 days (group 3) of keratitis induction (n = 12–16 rabbits/group). The 2 treatment groups were assigned to 50 μL of 4 mg/mL eugenol drops hourly for 15 days, while the control group received saline. Corneal penetration of eugenol was measured using HPLC, and corneal toxicity was evaluated clinically and histopathologically. Results: The in vitro minimum inhibitory concentrations of eugenol and fluconazole against C. albicans were 2 and > 0.4 mg/mL, respectively. A 4-mg/mL preparation of eugenol in propylene glycol was the maximum nontoxic dose on rabbit corneas as suggested by clinical and histopathologic findings. At least 75% of all eugenol-treated eyes recovered from keratitis, with improvement in the remaining 25% of the eyes compared to controls. Conclusions: Eugenol can act as a natural, safe, and effective treatment for fungal keratitis, regardless of whether treatment is started immediately or after 4 days of keratitis induction.

show abstract

“…TRPV1 agonists and antagonists have demonstrated an analgesic effect on both infl ammatory and neuropathic pain (Caterina et al, 1997;Ohkubo and Shibabta, 1997;Tominaga et al, 1998). Some natural substances have shown agonistic with subsequent desensitization for vanilloid receptors such as eugenol (Szallasi and Blumberg, 1993), guaiacol (Ohkubo and Shibata, 1997), zingerone (Liu and Simon, 1996), scutigeral , olvanil (Lawand et al, 1997) and trialkylglycine (Garcia-Martinez et al, 2002). Vanilloid receptors modulate pain at central and peripheral levels (McGaraughty et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Eugenol has different pharmacological properties such as dental analgesia L. LIONNET ET AL. (Kozam, 1977;Ohkubo and Shibata, 1997), an antiinfl ammatory effect by inhibiting thromboxane biosynthesis (Reddy and Lokesh, 1994), antibacterial effect (Laekeman et al, 1990), neuroprotective effect (Wie et al, 1997), anesthetic effect , as well as anticancer (Newmark, 1996), antihistaminic (Nishijima et al, 1998), antianaphylactic (Jadhav et al, 2004), antioxidant (Chen et al, 2009) and antifungal effect on Candida albicans (He et al, 2007;Chami et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Intrathecal eugenol administration alleviates neuropathic pain in male Sprague‐Dawley rats

Lionnet

Beaudry

Vachon

2010

Phytotherapy Research

View full text Add to dashboard Cite

The main objective of this study was to determine the central effect of eugenol on neuropathic pain when injected intrathecally at the level of the lumbar spinal cord. In a preliminary study the penetrability of eugenol was evaluated in the CNS of rats. Blood, brain and spinal cord samples were collected at selected time points following eugenol administration and concentrations were determined by tandem liquid chromatography-mass spectrometry. Brain-to-plasma and spinal cord-to-plasma ratios (3.3 and 6.7, respectively) suggest that eugenol penetrates relatively well the CNS of rats, with a preferential distribution in the spinal cord. Following the induction of neuropathic pain in rats using the sciatic nerve ligation model, intrathecal injections of eugenol were done to evaluate the central effect of eugenol. Treatment with 50 μg of eugenol significantly decreased secondary mechanical allodynia after 15 min, 2 h and 4 h (p < 0.05; <0.005; <0.05, respectively) and improved thermal hyperalgesia after 2 h and 4 h (p < 0.001 and p < 0.05). The results support the hypothesis that eugenol may alleviate neuropathic pain, both allodynia and hyperalgesia, by acting centrally most probably at the level of the dorsal horn of the spinal cord where vanilloid receptors can be found.

show abstract

The Selective Capsaicin Antagonist Capsazepine Abolishes the Antinociceptive Action of Eugenol and Guaiacol

Cited by 91 publications

References 10 publications

Experimental study of various central nervous system effects of eugenol in mice and rats

Experimental study of various central nervous system effects of eugenol in mice and rats

Topical Eugenol Successfully Treats Experimental <b><i>Candida albicans</i></b>-Induced Keratitis

Intrathecal eugenol administration alleviates neuropathic pain in male Sprague‐Dawley rats

Contact Info

Product

Resources

About