The sedative effects of hops<i>(Humulus lupulus)</i>, a component of beer, on the activity/rest rhythm

Franco, Lourdes; Sánchez, Cristina; Bravo, Rafael; Rodríguez, A.; Barriga, C.; Juánez, Javier Cubero

doi:10.1556/aphysiol.99.2012.2.6

Cited by 43 publications

(33 citation statements)

References 19 publications

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“…Ageing is a very complex process that shows symptoms of chronodisruption that produces sleep disturbances (30) and other physiological or psychological dysfunctions (2), including impaired nutrient absorption (37,47), immunosenescence (9,31,48), decrease in hormone levels (38), and neuronal cell death (20,40). The elderly rats used in our research showed such chronodisruption symptoms as an increase in diurnal activity (sleep time) and intraday variability in locomotor activity.…”

Section: Discussionmentioning

confidence: 92%

Activity/inactivity circadian rhythm shows high similarities between young obesity-induced rats and old rats

Bravo

Delgado

Juánez

et al. 2016

Acta Physiologica Hungarica

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The objective of the present study was to compare differences between elderly rats and young obesity-induced rats in their activity/inactivity circadian rhythm. The investigation was motivated by the differences reported previously for the circadian rhythms of both obese and elderly humans (and other animals), and those of healthy, young or mature individuals. Three groups of rats were formed: a young control group which was fed a standard chow for rodents; a young obesity-induced group which was fed a high-fat diet for four months; and an elderly control group with rats aged 2.5 years that was fed a standard chow for rodents. Activity/inactivity data were registered through actimetry using infrared actimeter systems in each cage to detect activity. Data were logged on a computer and chronobiological analysis were performed. The results showed diurnal activity (sleep time), nocturnal activity (awake time), amplitude, acrophase, and interdaily stability to be similar between the young obesity-induced group and the elderly control group, but different in the young control group. We have concluded that obesity leads to a chronodisruption status in the body similar to the circadian rhythm degradation observed in the elderly.

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Section: Discussionmentioning

confidence: 92%

Activity/inactivity circadian rhythm shows high similarities between young obesity-induced rats and old rats

Bravo

Delgado

Juánez

et al. 2016

Acta Physiologica Hungarica

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“…The mechanism of the action of these components is to activate the neurotransmitter γ-aminobutyric acid (GABA) by modulating brain GABA(A) receptors (24), thus inhibiting the central nervous system. In particular, this effect of hops on the nervous system has been reported in animal model studies (11,21,44), it also has a narcotic effect of high concentrations of hop extract due to its aforementioned 2-methyl-3-buten-2-ol component (9,42). Basic research on hops has been used to help healthy stress free human population to sleep (31,38).…”

mentioning

confidence: 72%

“…It is also the only drink that contains hops (Humulus lupulus), a plant with sedative properties. Hop contains α-acids bitter, 2-methyl-3-buten-2-ol, acting on neurotransmitter GABA effects, the major inhibitory neurotransmitter in the central nervous system; it also contains xanthumol and myrcenol both of them are present in the hop of the beer, providing its sedative properties that act in the same way as α-acids bitter on the neurotransmitter GABA (11,38).…”

mentioning

confidence: 99%

Effect of non-alcoholic beer on Subjective Sleep Quality in a university stressed population

Franco¹,

Bravo²,

Galán³

et al. 2014

Acta Physiologica Hungarica

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Sleep deprivation affects the homeostasis of the physiological functions in the human organism. Beer is the only beverage that contains hops, a plant which has a sedative effect. Our objective is to determine the improvement of subjective sleep quality using the Pittsburgh Sleep Quality Index (PSQI). The sample was conducted among a population of 30 university students. The study took place during a period of 3 weeks, the first 7 days were used for the Control, and during the following 14 days the students ingested beer (were asked to drink non-alcoholic beer) while having dinner. The results revealed that Subjective Sleep Quality improved in the case of those students who drank one beer during dinner compared to the Control, this is corroborated by the fact that Sleep Latency decreased (p < 0.05) compared to their Control. The overall rating Global Score of Quality of Sleep also improved significantly (p < 0.05). These results confirm that the consumption of non-alcoholic beer at dinner time helps to improve the quality of sleep at night.

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“…38 A study in quail supported this idea somewhat, showing that low doses of hops (similar to concentrations found in nonalcoholic beer) seemed to enhance circadian rhythms, including reduced activity at night. 39 Binding of hops extract compounds to 5-HT 6 , 5-HT 7 , melatonin-1, and melatonin-2 receptors was seen in another in vitro study. 40 Various hops constituents may also activate the GABA A receptor.…”

Section: Moderate Potency Hypnotic Herbsmentioning

confidence: 90%

Herbal Medicine for Insomnia

Yarnell

2015

Alternative and Complementary Therapies

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Insomnia is a common problem, and herbs can be quite helpful and are much safer than most drugs for insomnia. Moderately potent herbs that primarily work by enhancing sleep architecture or quality are reviewed in detail. These include Valeriana officinalis (valerian), Valeriana sitchensis (Pacific valerian) and related species, Humulus lupulus (hops), and Piscidia piscipula (Jamaica dogwood). Much milder nervines, requiring long-term use for full benefits-including Passiflora incarnata (passionflower), Melissa officinalis (lemonbalm), Nepeta cataria (catnip), Scutellaria lateriflora (skullcap), and Centella asiatica (gotu kola)-are discussed, and their place in improving insomnia is clarified. The much stronger and less often used sedative herbs Gelsemium sempervirens (gelsemium), Pulsatilla vulgaris (common pasque flower), P. patens (Eastern pasque flower), Anemone (Pulsatilla) occidentalis (western pasque flower), and A. tuberosa (desert anemone) are considered next. Finally, the delayedonset sleep-maintaining herb Myristica fragrans (nutmeg) is put into clinical context.

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The sedative effects of hops(Humulus lupulus), a component of beer, on the activity/rest rhythm

Cited by 43 publications

References 19 publications

Activity/inactivity circadian rhythm shows high similarities between young obesity-induced rats and old rats

Activity/inactivity circadian rhythm shows high similarities between young obesity-induced rats and old rats

Effect of non-alcoholic beer on Subjective Sleep Quality in a university stressed population

Herbal Medicine for Insomnia

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