The Secretor Status of Rheumatic-Fever Patients

Glynn, A. A.; Glynn, L. E.; Holborow, E. J.

doi:10.1016/s0140-6736(56)90964-3

Cited by 45 publications

(23 citation statements)

References 11 publications

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“…The reported association between nonsecretion of ABH substances and rheumatic fever (117) was not verified in a study of Dublin et al (76), al though such an association was suggested in females. In a subsequent analy sis of these data, Chung et al (57) found no evidence that heterozygous secretors have a greater susceptibility than homozygous secretors.…”

Section: Disease Associations With Genetic Markersmentioning

confidence: 87%

Human Genetics

Sutton

1967

Annu. Rev. Genet.

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Studies of human heredity have advanced in many areas and have con tributed to the understanding of basic genetic mechanisms. To enumerate all the advances is beyond the scope of the assignment (and the abilities of the reviewer), not to mention the page limitations imposed by the editors. Those papers discussed here are a sample, hopefully not random, of de velopments primarily in 1965 and 1966. This period was selected in part be cause of the excellent review of human genetics assembled for the Cold Spring Harbor Symposium in 1964 (64).

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Section: Disease Associations With Genetic Markersmentioning

confidence: 87%

Human Genetics

Sutton

1967

Annu. Rev. Genet.

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“…Larsson (1960) employed Guild's (1944) post-mortem material to calculate the degree of manifestation at 25 per cent ±8.5 per cent. Larsson's percentages of secondary cases are somewhat smaller than in this survey, though his general results and conclusions are similar.…”

Section: Manifestation In Otosclerosismentioning

confidence: 99%

“…The secretor states were compared with the mean figures from two large English series, namely those of 460 schoolchildren from Taplow (Glynn et al, 1956) and 851 normal controls from Liverpool (Clarke, 1960 (1955), using a discontinuous buffer (starch gel) system. The results obtained were compared to those given by Harris (1961), which corresponded well to those of Jensen (1958) in his series of 2,046 normal adults.…”

Section: Partial Sex Limitationmentioning

confidence: 99%

Genetic Factors in Otosclerosis

1967

The Lancet

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“…The lower immunoglobulin levels found in non-secretors compared with secretors have been used to explain the increased susceptibility of nonsecretors to rheumatic fever and rheumatic heart disease [16,17]. In later studies, non-secretors were reported to have lower levels of both serum [18] and salivary [19] IgA.…”

Section: Introductionmentioning

confidence: 99%

Secretor status and humoral immune responses to Neisseria lactamica and Neisseria meningitidis

Zorgani¹,

Stewart²,

Blackwell³

et al. 1992

Epidemiol. Infect.

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SUMMARYNon-secretors of ABO blood group antigens are over-represented among patients with meningococcal diseases. Lower levels of secretory IgA reported for non-secretors have been suggested to compromise mucosal defences. Total serum and salivary IgG, IgA and IgM and levels of these isotypes specific for Neisseria lactamica and five isolates of meningococci were determined by ELISA for 357 pupils and staff of a secondary school in which an outbreak of meningitis occurred. There were no differences in total or specific levels of serum IgG, IgA or IgM or salivary IgG or IgA of secretors compared with non-secretors. Non-secretors had significantly lower levels of salivary IgM (P = 0022) A similar pattern was observed for levels of IgM specific for N. lactamica and five meningococcal isolates. The significance of these results is discussed with reference to the role of secretory IgM in protection of mucosal surfaces in infants.

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The Secretor Status of Rheumatic-Fever Patients

Cited by 45 publications

References 11 publications

Human Genetics

Human Genetics

Genetic Factors in Otosclerosis

Secretor status and humoral immune responses to Neisseria lactamica and Neisseria meningitidis

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